ID:MIB1_MOUSE DESCRIPTION: RecName: Full=E3 ubiquitin-protein ligase MIB1; EC=6.3.2.-; AltName: Full=DAPK-interacting protein 1; Short=DIP-1; AltName: Full=Mind bomb homolog 1; FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation (By similarity). Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis. PATHWAY: Protein modification; protein ubiquitination. SUBCELLULAR LOCATION: Cytoplasm. Cell membrane. Note=Localizes to the plasma membrane. TISSUE SPECIFICITY: Detected in all tissues tested. Present in embryo, embryonic stem cells, bladder, skeletal muscle, bladder, uterus, testis, stomach, colon, ileum, trachea, lung, aorta, kidney, spleen, liver and vas deferens (at protein level). Highly expressed in testis. DEVELOPMENTAL STAGE: Highly expressed both in embryos and adult tissues. In E9.5 and E10.5 embryos, it is expressed in the tail bud, limb buds and somites. Expressed in the same pattern than MIB2 in the skin and intestine at postnatal day 1 (P1) and in the hair follicle in the skin in the adult. PTM: Ubiquitinated. Possibly via autoubiquitination. SIMILARITY: Contains 9 ANK repeats. SIMILARITY: Contains 2 MIB/HERC2 domains. SIMILARITY: Contains 3 RING-type zinc fingers. SIMILARITY: Contains 1 ZZ-type zinc finger. SEQUENCE CAUTION: Sequence=AAH11287.1; Type=Erroneous initiation; Sequence=AAH69870.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA; Sequence=AAN18022.1; Type=Erroneous initiation; Sequence=BAC38042.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the C-terminal part;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q80SY4
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.