Mouse Gene Mib1 (ENSMUST00000165555.7) Description and Page Index
  Description: Mus musculus mindbomb E3 ubiquitin protein ligase 1 (Mib1), transcript variant 1, mRNA. (from RefSeq NM_144860)
Gencode Transcript: ENSMUST00000165555.7
Gencode Gene: ENSMUSG00000024294.14
Transcript (Including UTRs)
   Position: mm10 chr18:10,725,655-10,812,174 Size: 86,520 Total Exon Count: 22 Strand: +
Coding Region
   Position: mm10 chr18:10,726,305-10,812,125 Size: 85,821 Coding Exon Count: 21 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr18:10,725,655-10,812,174)mRNA (may differ from genome)Protein (1006 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: MIB1_MOUSE
DESCRIPTION: RecName: Full=E3 ubiquitin-protein ligase MIB1; EC=6.3.2.-; AltName: Full=DAPK-interacting protein 1; Short=DIP-1; AltName: Full=Mind bomb homolog 1;
FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation (By similarity). Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis.
PATHWAY: Protein modification; protein ubiquitination.
SUBCELLULAR LOCATION: Cytoplasm. Cell membrane. Note=Localizes to the plasma membrane.
TISSUE SPECIFICITY: Detected in all tissues tested. Present in embryo, embryonic stem cells, bladder, skeletal muscle, bladder, uterus, testis, stomach, colon, ileum, trachea, lung, aorta, kidney, spleen, liver and vas deferens (at protein level). Highly expressed in testis.
DEVELOPMENTAL STAGE: Highly expressed both in embryos and adult tissues. In E9.5 and E10.5 embryos, it is expressed in the tail bud, limb buds and somites. Expressed in the same pattern than MIB2 in the skin and intestine at postnatal day 1 (P1) and in the hair follicle in the skin in the adult.
PTM: Ubiquitinated. Possibly via autoubiquitination.
SIMILARITY: Contains 9 ANK repeats.
SIMILARITY: Contains 2 MIB/HERC2 domains.
SIMILARITY: Contains 3 RING-type zinc fingers.
SIMILARITY: Contains 1 ZZ-type zinc finger.
SEQUENCE CAUTION: Sequence=AAH11287.1; Type=Erroneous initiation; Sequence=AAH69870.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA; Sequence=AAN18022.1; Type=Erroneous initiation; Sequence=BAC38042.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the C-terminal part;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -67.50146-0.462 Picture PostScript Text
3' UTR -4.3049-0.088 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002110 - Ankyrin_rpt
IPR020683 - Ankyrin_rpt-contain_dom
IPR010606 - Mib_Herc2
IPR001841 - Znf_RING
IPR013083 - Znf_RING/FYVE/PHD
IPR000433 - Znf_ZZ

Pfam Domains:
PF00023 - Ankyrin repeat
PF00569 - Zinc finger, ZZ type
PF06701 - Mib_herc2
PF12796 - Ankyrin repeats (3 copies)
PF13606 - Ankyrin repeat
PF13637 - Ankyrin repeats (many copies)
PF13857 - Ankyrin repeats (many copies)
PF13920 - Zinc finger, C3HC4 type (RING finger)
PF13923 - Zinc finger, C3HC4 type (RING finger)

SCOP Domains:
140860 - Pseudo ankyrin repeat-like
48695 - Multiheme cytochromes
159034 - Mib/herc2 domain-like
48403 - Ankyrin repeat
57850 - RING/U-box
57924 - Inhibitor of apoptosis (IAP) repeat

ModBase Predicted Comparative 3D Structure on Q80SY4
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologGenome BrowserNo orthologNo ortholog
Gene Details     
Gene Sorter     
GenBankRGDEnsemblEnsembl  
Protein SequenceProtein Sequence Protein Sequence  
AlignmentAlignment Alignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016740 transferase activity
GO:0046872 metal ion binding

Biological Process:
GO:0001568 blood vessel development
GO:0001701 in utero embryonic development
GO:0001756 somitogenesis
GO:0001841 neural tube formation
GO:0001947 heart looping
GO:0007219 Notch signaling pathway
GO:0007507 heart development
GO:0016567 protein ubiquitination
GO:0045665 negative regulation of neuron differentiation
GO:0045807 positive regulation of endocytosis

Cellular Component:
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005815 microtubule organizing center
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0031410 cytoplasmic vesicle


-  Descriptions from all associated GenBank mRNAs
  AY245539 - Mus musculus DAPK-interacting protein-1 mRNA, complete cds.
BC131662 - Mus musculus mindbomb homolog 1 (Drosophila), mRNA (cDNA clone MGC:150185 IMAGE:40110696), complete cds.
AK139338 - Mus musculus 10 days neonate cortex cDNA, RIKEN full-length enriched library, clone:A830015A18 product:mindbomb homolog 1 (Drosophila), full insert sequence.
AY147848 - Mus musculus MINDBOMB (Mib) mRNA, complete cds.
AY149907 - Mus musculus mind bomb (Mib) mRNA, complete cds.
AY974091 - Mus musculus mind bomb-1 mRNA, complete cds.
AK047455 - Mus musculus 10 days neonate cerebellum cDNA, RIKEN full-length enriched library, clone:B930066F21 product:unclassifiable, full insert sequence.
AK080847 - Mus musculus adult male corpora quadrigemina cDNA, RIKEN full-length enriched library, clone:B230369E20 product:hypothetical Ankyrin repeat profile/Cysteine-rich region/Ankyrin-repeat/RING finger/Ankyrin repeat region circular profile/Yeast DNA-binding domain containing protein, full insert sequence.
AK053035 - Mus musculus 15 days embryo head cDNA, RIKEN full-length enriched library, clone:D930027G22 product:hypothetical protein, full insert sequence.
AK042441 - Mus musculus 3 days neonate thymus cDNA, RIKEN full-length enriched library, clone:A630091O15 product:unclassifiable, full insert sequence.
BC069870 - Mus musculus mindbomb homolog 1 (Drosophila), mRNA (cDNA clone IMAGE:5032493), partial cds.
BC083072 - Mus musculus mindbomb homolog 1 (Drosophila), mRNA (cDNA clone IMAGE:6336184), partial cds.
AK053011 - Mus musculus 15 days embryo head cDNA, RIKEN full-length enriched library, clone:D930015D10 product:unclassifiable, full insert sequence.
BC011287 - Mus musculus mindbomb homolog 1 (Drosophila), mRNA (cDNA clone IMAGE:3981221), complete cds.
AK161848 - Mus musculus adult male medulla oblongata cDNA, RIKEN full-length enriched library, clone:6330415C08 product:mindbomb homolog 1 (Drosophila), full insert sequence.
AK129331 - Mus musculus mRNA for mKIAA1323 protein.
AK081370 - Mus musculus 16 days embryo head cDNA, RIKEN full-length enriched library, clone:C130011K21 product:unclassifiable, full insert sequence.

-  Other Names for This Gene
  Alternate Gene Symbols: Dip1, Kiaa1323, Mib, MIB1_MOUSE, NM_144860, Q5XK51, Q6IS57, Q6YI52, Q6ZPT8, Q80SY4, Q8BNR1, Q8C6W2, Q921Q1, uc289nyw.1
UCSC ID: uc289nyw.1
RefSeq Accession: NM_144860
Protein: Q80SY4 (aka MIB1_MOUSE)
CCDS: CCDS29058.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.