Mouse Gene Ppfia2 (ENSMUST00000217854.1) Description and Page Index
  Description: Mus musculus protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2 (Ppfia2), transcript variant 1, mRNA. (from RefSeq NM_001205341)
Gencode Transcript: ENSMUST00000217854.1
Gencode Gene: ENSMUSG00000053825.15
Transcript (Including UTRs)
   Position: mm10 chr10:106,470,346-106,935,952 Size: 465,607 Total Exon Count: 32 Strand: +
Coding Region
   Position: mm10 chr10:106,474,634-106,929,112 Size: 454,479 Coding Exon Count: 30 

Page IndexSequence and LinksCTDRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr10:106,470,346-106,935,952)mRNA (may differ from genome)Protein (1257 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedReactomeStanford SOURCEUniProtKB

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -73.70248-0.297 Picture PostScript Text
3' UTR -1138.004863-0.234 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001660 - SAM
IPR013761 - SAM/pointed
IPR011510 - SAM_2
IPR021129 - SAM_type1

Pfam Domains:
PF00536 - SAM domain (Sterile alpha motif)
PF07647 - SAM domain (Sterile alpha motif)

SCOP Domains:
47769 - SAM/Pointed domain

ModBase Predicted Comparative 3D Structure on B8QI34
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details    Gene Details
Gene Sorter    Gene Sorter
GenBankRGDEnsembl  SGD
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0045202 synapse


-  Descriptions from all associated GenBank mRNAs
  BC065133 - Mus musculus protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2, mRNA (cDNA clone MGC:86108 IMAGE:30536236), complete cds.
EU568870 - Mus musculus liprin-alpha 2 (ppfia2) mRNA, complete cds.
AK030621 - Mus musculus adult male pituitary gland cDNA, RIKEN full-length enriched library, clone:5330438O12 product:hypothetical protein, full insert sequence.
AK220491 - Mus musculus mRNA for mKIAA4112 protein.
LF198224 - JP 2014500723-A/5727: Polycomb-Associated Non-Coding RNAs.
LF203850 - JP 2014500723-A/11353: Polycomb-Associated Non-Coding RNAs.
LF202976 - JP 2014500723-A/10479: Polycomb-Associated Non-Coding RNAs.
MA433801 - JP 2018138019-A/5727: Polycomb-Associated Non-Coding RNAs.
MA439427 - JP 2018138019-A/11353: Polycomb-Associated Non-Coding RNAs.
MA438553 - JP 2018138019-A/10479: Polycomb-Associated Non-Coding RNAs.
AK087448 - Mus musculus 0 day neonate eyeball cDNA, RIKEN full-length enriched library, clone:E130120L08 product:hypothetical SAM domain (Sterile alpha motif) containing protein, full insert sequence.
AK043021 - Mus musculus 7 days neonate cerebellum cDNA, RIKEN full-length enriched library, clone:A730048J02 product:inferred: liprin-alpha2 {Homo sapiens}, full insert sequence.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein B8QI34 (Reactome details) participates in the following event(s):

R-MMU-210426 Glutamate synaptic vesicle docking and priming
R-MMU-372505 Acetylcholine synaptic vesicle docking and priming
R-MMU-374922 Noradrenalin synaptic vesicle docking and priming
R-MMU-380574 Dopamine synaptic vesicle docking and priming
R-MMU-380905 Serotonin loaded synaptic vesicle docking and priming
R-MMU-210430 release of L-Glutamate at the synapse
R-MMU-372529 Release of acetylcholine at the synapse
R-MMU-374899 Release of noradrenaline at the synapse
R-MMU-380869 Release of docked dopamine loaded synaptic vesicle
R-MMU-380901 Release of docked serotonin loaded synaptic vesicle
R-MMU-388824 PTPRF, PTPRS, PTPRD bind Liprins
R-MMU-210500 Glutamate Neurotransmitter Release Cycle
R-MMU-264642 Acetylcholine Neurotransmitter Release Cycle
R-MMU-181430 Norepinephrine Neurotransmitter Release Cycle
R-MMU-212676 Dopamine Neurotransmitter Release Cycle
R-MMU-181429 Serotonin Neurotransmitter Release Cycle
R-MMU-388844 Receptor-type tyrosine-protein phosphatases
R-MMU-112310 Neurotransmitter release cycle
R-MMU-6794362 Protein-protein interactions at synapses
R-MMU-112315 Transmission across Chemical Synapses
R-MMU-112316 Neuronal System

-  Other Names for This Gene
  Alternate Gene Symbols: B8QI34, B8QI34_MOUSE, NM_001205341, uc007gys.1, uc007gys.2, uc007gys.3
UCSC ID: uc007gys.3
RefSeq Accession: NM_001205341
Protein: B8QI34 CCDS: CCDS56746.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.