Human Gene FOXRED2 (ENST00000216187.10) Description and Page Index
  Description: Homo sapiens FAD dependent oxidoreductase domain containing 2 (FOXRED2), transcript variant 1, mRNA. (from RefSeq NM_024955)
Gencode Transcript: ENST00000216187.10
Gencode Gene: ENSG00000100350.14
Transcript (Including UTRs)
   Position: hg38 chr22:36,488,242-36,507,022 Size: 18,781 Total Exon Count: 9 Strand: -
Coding Region
   Position: hg38 chr22:36,490,008-36,506,422 Size: 16,415 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Methods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr22:36,488,242-36,507,022)mRNA (may differ from genome)Protein (684 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
HPRDLynxMGIneXtProtOMIMPubMed
Stanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: FXRD2_HUMAN
DESCRIPTION: RecName: Full=FAD-dependent oxidoreductase domain-containing protein 2; AltName: Full=Endoplasmic reticulum flavoprotein associated with degradation; Flags: Precursor;
FUNCTION: Probable flavoprotein which may function in endoplasmic reticulum associated degradation (ERAD). May bind non-native proteins in the endoplasmic reticulum and target them to the ubiquitination machinery for subsequent degradation.
COFACTOR: FAD.
SUBUNIT: Interacts with SEL1L. May interact with OS9 and DNAJC10.
SUBCELLULAR LOCATION: Endoplasmic reticulum lumen.
PTM: N-glycosylated.
SIMILARITY: Belongs to the FOXRED2 family.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 8.53 RPKM in Brain - Frontal Cortex (BA9)
Total median expression: 182.95 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -50.40112-0.450 Picture PostScript Text
3' UTR -608.201766-0.344 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  ModBase Predicted Comparative 3D Structure on Q8IWF2
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0050660 flavin adenine dinucleotide binding

Biological Process:
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process
GO:0055114 oxidation-reduction process

Cellular Component:
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen


-  Descriptions from all associated GenBank mRNAs
  BC027716 - Homo sapiens FAD-dependent oxidoreductase domain containing 2, mRNA (cDNA clone MGC:16700 IMAGE:4127473), complete cds.
JD442572 - Sequence 423596 from Patent EP1572962.
JD138542 - Sequence 119566 from Patent EP1572962.
JD329469 - Sequence 310493 from Patent EP1572962.
JD441565 - Sequence 422589 from Patent EP1572962.
JD330918 - Sequence 311942 from Patent EP1572962.
JD446964 - Sequence 427988 from Patent EP1572962.
JD540535 - Sequence 521559 from Patent EP1572962.
JD277903 - Sequence 258927 from Patent EP1572962.
JD158726 - Sequence 139750 from Patent EP1572962.
JD260260 - Sequence 241284 from Patent EP1572962.
JD556373 - Sequence 537397 from Patent EP1572962.
JD421238 - Sequence 402262 from Patent EP1572962.
JD094172 - Sequence 75196 from Patent EP1572962.
JD379781 - Sequence 360805 from Patent EP1572962.
JD179265 - Sequence 160289 from Patent EP1572962.
JD239095 - Sequence 220119 from Patent EP1572962.
AK091053 - Homo sapiens cDNA FLJ33734 fis, clone BRAWH2018282, moderately similar to Thioredoxin, mitochondrial.
JD558994 - Sequence 540018 from Patent EP1572962.
JD092352 - Sequence 73376 from Patent EP1572962.
JD258432 - Sequence 239456 from Patent EP1572962.
JD376753 - Sequence 357777 from Patent EP1572962.
BC015726 - Homo sapiens FAD-dependent oxidoreductase domain containing 2, mRNA (cDNA clone MGC:22928 IMAGE:4866761), complete cds.
BC040351 - Homo sapiens FAD-dependent oxidoreductase domain containing 2, mRNA (cDNA clone MGC:21496 IMAGE:3873448), complete cds.
JD092250 - Sequence 73274 from Patent EP1572962.
JD243429 - Sequence 224453 from Patent EP1572962.
JD500380 - Sequence 481404 from Patent EP1572962.
AK025714 - Homo sapiens cDNA: FLJ22061 fis, clone HEP10105.
AK026975 - Homo sapiens cDNA: FLJ23322 fis, clone HEP12410.
JD152486 - Sequence 133510 from Patent EP1572962.
JD161866 - Sequence 142890 from Patent EP1572962.
JD521000 - Sequence 502024 from Patent EP1572962.
JD198711 - Sequence 179735 from Patent EP1572962.
JD287693 - Sequence 268717 from Patent EP1572962.
JD452876 - Sequence 433900 from Patent EP1572962.
JD184817 - Sequence 165841 from Patent EP1572962.
JD155439 - Sequence 136463 from Patent EP1572962.
JD226504 - Sequence 207528 from Patent EP1572962.
JD439584 - Sequence 420608 from Patent EP1572962.
JD117829 - Sequence 98853 from Patent EP1572962.
JD541375 - Sequence 522399 from Patent EP1572962.
JD150271 - Sequence 131295 from Patent EP1572962.
JD521452 - Sequence 502476 from Patent EP1572962.
JD191363 - Sequence 172387 from Patent EP1572962.
JD126155 - Sequence 107179 from Patent EP1572962.
AK225347 - Homo sapiens mRNA for hypothetical protein LOC80020 variant, clone: HEP10105.
JD269968 - Sequence 250992 from Patent EP1572962.
JD170545 - Sequence 151569 from Patent EP1572962.
JD188536 - Sequence 169560 from Patent EP1572962.
JD394041 - Sequence 375065 from Patent EP1572962.
CR456444 - Homo sapiens dJ1119A7.3 full length open reading frame (ORF) cDNA clone (cDNA clone C22ORF:pGEM.dJ1119A7.3).
JD360814 - Sequence 341838 from Patent EP1572962.
CU013042 - Homo sapiens dJ1119A7.C22.3, mRNA (cDNA clone IMAGE:100000300), complete cds, with stop codon, in Gateway system.
KJ906328 - Synthetic construct Homo sapiens clone ccsbBroadEn_15998 FOXRED2 gene, encodes complete protein.
AK315555 - Homo sapiens cDNA, FLJ96626.
KJ894773 - Synthetic construct Homo sapiens clone ccsbBroadEn_04167 FOXRED2 gene, encodes complete protein.
AB527146 - Synthetic construct DNA, clone: pF1KE0341, Homo sapiens FOXRED2 gene for FAD-dependent oxidoreductase domain containing 2, without stop codon, in Flexi system.
CU013330 - Homo sapiens dJ1119A7.C22.3, mRNA (cDNA clone IMAGE:100000204), complete cds, without stop codon, in Gateway system.
CU691858 - Synthetic construct Homo sapiens gateway clone IMAGE:100017453 5' read FOXRED2 mRNA.
JD256374 - Sequence 237398 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B2RDI4, ERFAD, FXRD2_HUMAN, NM_024955, Q8IWF2, Q8N378, Q96BD1, Q9H5L5, Q9H6M8, uc003apo.1, uc003apo.2, uc003apo.3, uc003apo.4, uc003apo.5
UCSC ID: uc003apo.5
RefSeq Accession: NM_024955
Protein: Q8IWF2 (aka FXRD2_HUMAN)
CCDS: CCDS13929.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.