ID:FXRD2_HUMAN DESCRIPTION: RecName: Full=FAD-dependent oxidoreductase domain-containing protein 2; AltName: Full=Endoplasmic reticulum flavoprotein associated with degradation; Flags: Precursor; FUNCTION: Probable flavoprotein which may function in endoplasmic reticulum associated degradation (ERAD). May bind non-native proteins in the endoplasmic reticulum and target them to the ubiquitination machinery for subsequent degradation. COFACTOR: FAD. SUBUNIT: Interacts with SEL1L. May interact with OS9 and DNAJC10. SUBCELLULAR LOCATION: Endoplasmic reticulum lumen. PTM: N-glycosylated. SIMILARITY: Belongs to the FOXRED2 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
ModBase Predicted Comparative 3D Structure on Q8IWF2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.