Human Gene RPL22 (ENST00000234875.9) from GENCODE V44
Description: Homo sapiens ribosomal protein L22 (RPL22), mRNA. (from RefSeq NM_000983) RefSeq Summary (NM_000983): Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 60S subunit. The protein belongs to the L22E family of ribosomal proteins. Its initiating methionine residue is post-translationally removed. The protein can bind specifically to Epstein-Barr virus-encoded RNAs (EBERs) 1 and 2. The mouse protein has been shown to be capable of binding to heparin. Transcript variants utilizing alternative polyA signals exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. It was previously thought that this gene mapped to 3q26 and that it was fused to the acute myeloid leukemia 1 (AML1) gene located at 21q22 in some therapy-related myelodysplastic syndrome patients with 3;21 translocations; however, these fusions actually involve a ribosomal protein L22 pseudogene located at 3q26, and this gene actually maps to 1p36.3-p36.2. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000234875.9 Gencode Gene: ENSG00000116251.11 Transcript (Including UTRs) Position: hg38 chr1:6,185,020-6,199,595 Size: 14,576 Total Exon Count: 4 Strand: - Coding Region Position: hg38 chr1:6,186,672-6,199,573 Size: 12,902 Coding Exon Count: 4
ID:RL22_HUMAN DESCRIPTION: RecName: Full=60S ribosomal protein L22; AltName: Full=EBER-associated protein; Short=EAP; AltName: Full=Epstein-Barr virus small RNA-associated protein; AltName: Full=Heparin-binding protein HBp15; MISCELLANEOUS: Binds to Epstein-Barr virus small RNAs and to heparin. SIMILARITY: Belongs to the ribosomal protein L22e family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF01776 - Ribosomal L22e protein family
ModBase Predicted Comparative 3D Structure on P35268
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.