ID:IF4B_HUMAN DESCRIPTION: RecName: Full=Eukaryotic translation initiation factor 4B; Short=eIF-4B; FUNCTION: Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'- terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F. SUBUNIT: Self-associates and interacts with EIF3 p170 subunit. INTERACTION: P53350:PLK1; NbExp=3; IntAct=EBI-970310, EBI-476768; PTM: Phosphorylated at Ser-422 by RPS6KA1 and RPS6KB1; phosphorylation enhances the affinity of EIF4B for the EIF3 complex. SIMILARITY: Contains 1 RRM (RNA recognition motif) domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P23588
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK310244 - Homo sapiens cDNA, FLJ17286. AK299329 - Homo sapiens cDNA FLJ54492 complete cds, highly similar to Eukaryotic translation initiation factor 4B. AK222528 - Homo sapiens mRNA for eukaryotic translation initiation factor 4B variant, clone: adSE02039. AK293731 - Homo sapiens cDNA FLJ59206 complete cds, highly similar to Eukaryotic translation initiation factor 4B. AK299526 - Homo sapiens cDNA FLJ59405 complete cds, highly similar to Eukaryotic translation initiation factor 4B. AK299510 - Homo sapiens cDNA FLJ59402 complete cds, highly similar to Eukaryotic translation initiation factor 4B. BC073154 - Homo sapiens eukaryotic translation initiation factor 4B, mRNA (cDNA clone MGC:88034 IMAGE:6015183), complete cds. BC073139 - Homo sapiens eukaryotic translation initiation factor 4B, mRNA (cDNA clone MGC:88035 IMAGE:6527540), complete cds. BC098437 - Homo sapiens eukaryotic translation initiation factor 4B, mRNA (cDNA clone MGC:104867 IMAGE:6459393), complete cds. BC007745 - Homo sapiens cDNA clone IMAGE:4099384, containing frame-shift errors. CR627377 - Homo sapiens mRNA; cDNA DKFZp686O21248 (from clone DKFZp686O21248). CU687250 - Synthetic construct Homo sapiens gateway clone IMAGE:100023247 5' read EIF4B mRNA. CR456958 - Homo sapiens full open reading frame cDNA clone RZPDo834G0121D for gene EIF4B, eukaryotic translation initiation factor 4B; complete cds, incl. stopcodon. AB385251 - Synthetic construct DNA, clone: pF1KB9498, Homo sapiens EIF4B gene for eukaryotic translation initiation factor 4B, complete cds, without stop codon, in Flexi system. KJ896755 - Synthetic construct Homo sapiens clone ccsbBroadEn_06149 EIF4B gene, encodes complete protein. AB076839 - Homo sapiens eIF4B mRNA for initation factor 4B, complete cds. JD264465 - Sequence 245489 from Patent EP1572962. JD163476 - Sequence 144500 from Patent EP1572962. JD565898 - Sequence 546922 from Patent EP1572962. JD078291 - Sequence 59315 from Patent EP1572962. JD196925 - Sequence 177949 from Patent EP1572962. JD251383 - Sequence 232407 from Patent EP1572962. JD179009 - Sequence 160033 from Patent EP1572962. BC001097 - Homo sapiens eukaryotic translation initiation factor 4B, mRNA (cDNA clone IMAGE:3507583), partial cds. JD130118 - Sequence 111142 from Patent EP1572962. JD531265 - Sequence 512289 from Patent EP1572962. JD371874 - Sequence 352898 from Patent EP1572962. JD043472 - Sequence 24496 from Patent EP1572962. AK307496 - Homo sapiens cDNA, FLJ97444. JD269513 - Sequence 250537 from Patent EP1572962. AK092188 - Homo sapiens cDNA FLJ34869 fis, clone NT2NE2014650, highly similar to EUKARYOTIC TRANSLATION INITIATION FACTOR 4B. DL491009 - Novel nucleic acids. JD162569 - Sequence 143593 from Patent EP1572962. BC064029 - Homo sapiens cDNA clone IMAGE:6173372, partial cds. BC047302 - Homo sapiens, clone IMAGE:4444787, mRNA. JD041623 - Sequence 22647 from Patent EP1572962. JD054921 - Sequence 35945 from Patent EP1572962. JD435075 - Sequence 416099 from Patent EP1572962. JD552434 - Sequence 533458 from Patent EP1572962. JD118406 - Sequence 99430 from Patent EP1572962. JD024700 - Sequence 5724 from Patent EP1572962. BC007974 - Homo sapiens cDNA clone IMAGE:4297962, partial cds. JD035393 - Sequence 16417 from Patent EP1572962. JD028168 - Sequence 9192 from Patent EP1572962. BC013994 - Homo sapiens cDNA clone IMAGE:3629020, partial cds. JD111203 - Sequence 92227 from Patent EP1572962. JD526037 - Sequence 507061 from Patent EP1572962. JD114339 - Sequence 95363 from Patent EP1572962. DL490612 - Novel nucleic acids.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04150 - mTOR signaling pathway
Reactome (by CSHL, EBI, and GO)
Protein P23588 (Reactome details) participates in the following event(s):
R-HSA-165777 Phosphorylation and activation of eIF4B by activated S6K1 R-HSA-72619 eIF2:GTP is hydrolyzed, eIFs are released R-HSA-429955 CCR4-NOT complex deadenylates mRNA R-HSA-429992 PARN deadenylates mRNA R-HSA-72621 Ribosomal scanning R-HSA-157849 Formation of translation initiation complexes containing mRNA that does not circularize R-HSA-72697 Start codon recognition R-HSA-156823 Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA R-HSA-156808 Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation R-HSA-430021 PAN2-PAN3 complex partially deadenylates mRNA R-HSA-8941312 ZCCHC6, ZCCHC11 are mRNA uridyltransferases R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-166208 mTORC1-mediated signalling R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-429947 Deadenylation of mRNA R-HSA-72702 Ribosomal scanning and start codon recognition R-HSA-72649 Translation initiation complex formation R-HSA-156827 L13a-mediated translation R-HSA-72737 Cap-dependent Translation Initiation R-HSA-165159 mTOR signalling R-HSA-429914 Deadenylation-dependent mRNA decay R-HSA-72613 Eukaryotic Translation Initiation R-HSA-162582 Signal Transduction R-HSA-8953854 Metabolism of RNA R-HSA-72766 Translation R-HSA-392499 Metabolism of proteins
Sequence and Links to Tools and Databases 
Microarray Expression Data 
