Human Gene NLRP2 (ENST00000263437.10) Description and Page Index
Description: Homo sapiens NLR family pyrin domain containing 2 (NLRP2), transcript variant 5, mRNA. (from RefSeq NM_001348003) RefSeq Summary (NM_001348003): This gene is a member of the nucleotide-binding and leucine-rich repeat receptor (NLR) family, and is predicted to contain an N-terminal pyrin effector domain (PYD), a centrally-located nucleotide-binding and oligomerization domain (NACHT) and C-terminal leucine-rich repeats (LRR). Members of this gene family are thought to be important regulators of immune responses. This gene product interacts with components of the IkB kinase (IKK) complex, and can regulate both caspase-1 and NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells) activity. The pyrin domain is necessary and sufficient for suppression of NF-kB activity. An allelic variant (rs147585490) has been found that is incapable of blocking the transcriptional activity of NF-kB. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]. Gencode Transcript: ENST00000263437.10 Gencode Gene: ENSG00000022556.16 Transcript (Including UTRs) Position: hg38 chr19:54,966,406-55,001,135 Size: 34,730 Total Exon Count: 13 Strand: + Coding Region Position: hg38 chr19:54,970,016-55,000,898 Size: 30,883 Coding Exon Count: 12
ID:J3KN39_HUMAN DESCRIPTION: SubName: Full=NACHT, LRR and PYD domains-containing protein 2; SIMILARITY: Contains 1 DAPIN domain. CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on J3KN39
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.