Human Gene MYH10 (ENST00000269243.8) from GENCODE V38
  Description: Homo sapiens myosin heavy chain 10 (MYH10), transcript variant 2, mRNA. (from RefSeq NM_005964)
RefSeq Summary (NM_001256095): This gene encodes a member of the myosin superfamily. The protein represents a conventional non-muscle myosin; it should not be confused with the unconventional myosin-10 (MYO10). Myosins are actin-dependent motor proteins with diverse functions including regulation of cytokinesis, cell motility, and cell polarity. Mutations in this gene have been associated with May-Hegglin anomaly and developmental defects in brain and heart. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011].
Gencode Transcript: ENST00000269243.8
Gencode Gene: ENSG00000133026.13
Transcript (Including UTRs)
   Position: hg38 chr17:8,474,212-8,630,761 Size: 156,550 Total Exon Count: 41 Strand: -
Coding Region
   Position: hg38 chr17:8,475,804-8,623,246 Size: 147,443 Coding Exon Count: 40 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated at UCSC: 2021-09-27 09:51:20

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr17:8,474,212-8,630,761)mRNA (may differ from genome)Protein (1976 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Myosin-10; AltName: Full=Cellular myosin heavy chain, type B; AltName: Full=Myosin heavy chain 10; AltName: Full=Myosin heavy chain, non-muscle IIb; AltName: Full=Non-muscle myosin heavy chain B; Short=NMMHC-B; AltName: Full=Non-muscle myosin heavy chain IIb; Short=NMMHC II-b; Short=NMMHC-IIB;
FUNCTION: Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2.
SUBUNIT: Myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). Interacts with PLEKHG6. Interacts with ECM29. Interacts with KIF26B (By similarity). Interacts with LARP6.
TISSUE SPECIFICITY: Isoform 1 is expressed in cerebellum and spinal chord. Isoform 2 is expressed in cerebrum and retina. Isoform 3 is expressed in the cerebrum and to a much lower extent in cerebellum.
DOMAIN: The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
PTM: Phosphorylated by ABL2 (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR.
SIMILARITY: Contains 1 IQ domain.
SIMILARITY: Contains 1 myosin head-like domain.
CAUTION: Represents a conventional non-muscle myosin. This protein should not be confused with the unconventional myosin-10 (MYO10).

-  MalaCards Disease Associations
  MalaCards Gene Search: MYH10
Diseases sorted by gene-association score: may-hegglin anomaly (13), lymphangioleiomyomatosis (6), infantile myofibromatosis (5), intellectual disability (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 298.04 RPKM in Artery - Aorta
Total median expression: 1020.64 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -52.70139-0.379 Picture PostScript Text
3' UTR -452.901592-0.284 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000048 - IQ_motif_EF-hand-BS
IPR001609 - Myosin_head_motor_dom
IPR004009 - Myosin_N
IPR008989 - Myosin_S1_N
IPR002928 - Myosin_tail

Pfam Domains:
PF00612 - IQ calmodulin-binding motif
PF00063 - Myosin head (motor domain)
PF02736 - Myosin N-terminal SH3-like domain
PF01576 - Myosin tail

ModBase Predicted Comparative 3D Structure on P35580
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000146 microfilament motor activity
GO:0000166 nucleotide binding
GO:0003774 motor activity
GO:0003777 microtubule motor activity
GO:0003779 actin binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0008017 microtubule binding
GO:0016887 ATPase activity
GO:0030898 actin-dependent ATPase activity
GO:0035613 RNA stem-loop binding
GO:0043531 ADP binding
GO:0048027 mRNA 5'-UTR binding
GO:0051015 actin filament binding

Biological Process:
GO:0000281 mitotic cytokinesis
GO:0001701 in utero embryonic development
GO:0001764 neuron migration
GO:0001778 plasma membrane repair
GO:0003279 cardiac septum development
GO:0006887 exocytosis
GO:0006930 substrate-dependent cell migration, cell extension
GO:0007018 microtubule-based movement
GO:0007097 nuclear migration
GO:0007155 cell adhesion
GO:0007409 axonogenesis
GO:0007411 axon guidance
GO:0007420 brain development
GO:0007507 heart development
GO:0007512 adult heart development
GO:0008283 cell proliferation
GO:0008360 regulation of cell shape
GO:0021592 fourth ventricle development
GO:0021670 lateral ventricle development
GO:0021678 third ventricle development
GO:0021680 cerebellar Purkinje cell layer development
GO:0030036 actin cytoskeleton organization
GO:0030048 actin filament-based movement
GO:0030239 myofibril assembly
GO:0031032 actomyosin structure organization
GO:0031175 neuron projection development
GO:0035904 aorta development
GO:0050714 positive regulation of protein secretion
GO:0050885 neuromuscular process controlling balance
GO:0055003 cardiac myofibril assembly
GO:0055015 ventricular cardiac muscle cell development
GO:0060041 retina development in camera-type eye
GO:0060976 coronary vasculature development
GO:0098885 modification of postsynaptic actin cytoskeleton

Cellular Component:
GO:0001725 stress fiber
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005819 spindle
GO:0005829 cytosol
GO:0005844 polysome
GO:0005886 plasma membrane
GO:0005903 brush border
GO:0005938 cell cortex
GO:0016459 myosin complex
GO:0016460 myosin II complex
GO:0030027 lamellipodium
GO:0030424 axon
GO:0030426 growth cone
GO:0030496 midbody
GO:0031594 neuromuscular junction
GO:0032154 cleavage furrow
GO:0042641 actomyosin
GO:0042995 cell projection
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043197 dendritic spine
GO:0070062 extracellular exosome
GO:0097513 myosin II filament

-  Descriptions from all associated GenBank mRNAs
  AB210026 - Homo sapiens mRNA for MYH10 variant protein, clone: hf00991.
M69181 - Human nonmuscle myosin heavy chain-B (MYH10) mRNA, partial cds.
BC144668 - Homo sapiens myosin, heavy chain 10, non-muscle, mRNA (cDNA clone MGC:178216 IMAGE:9053199), complete cds.
BC150634 - Homo sapiens myosin, heavy chain 10, non-muscle, mRNA (cDNA clone MGC:183544 IMAGE:9057004), complete cds.
BC117690 - Homo sapiens myosin, heavy chain 10, non-muscle, mRNA (cDNA clone MGC:134913 IMAGE:40072059), complete cds.
BC117691 - Homo sapiens myosin, heavy chain 10, non-muscle, mRNA (cDNA clone MGC:134914 IMAGE:40072061), complete cds.
AB463132 - Synthetic construct DNA, clone: pF1KB0047, Homo sapiens MYH10 gene for myosin, heavy chain 10, non-muscle, without stop codon, in Flexi system.
BC008968 - Homo sapiens myosin, heavy chain 10, non-muscle, mRNA (cDNA clone IMAGE:3028454), partial cds.
BC000280 - Homo sapiens myosin, heavy chain 10, non-muscle, mRNA (cDNA clone IMAGE:3357927), partial cds.
AK026977 - Homo sapiens cDNA: FLJ23324 fis, clone HEP12482, highly similar to HUMMYOHCB Human nonmuscle myosin heavy chain-B (MYH10) mRNA.
JD407912 - Sequence 388936 from Patent EP1572962.
JD553081 - Sequence 534105 from Patent EP1572962.
JD283169 - Sequence 264193 from Patent EP1572962.
JD050133 - Sequence 31157 from Patent EP1572962.
JD245956 - Sequence 226980 from Patent EP1572962.
JD245955 - Sequence 226979 from Patent EP1572962.
JD555201 - Sequence 536225 from Patent EP1572962.
JD300132 - Sequence 281156 from Patent EP1572962.
JD379103 - Sequence 360127 from Patent EP1572962.
JD052682 - Sequence 33706 from Patent EP1572962.
JD250018 - Sequence 231042 from Patent EP1572962.
JD477755 - Sequence 458779 from Patent EP1572962.
JD185006 - Sequence 166030 from Patent EP1572962.
JD077688 - Sequence 58712 from Patent EP1572962.
AF086505 - Homo sapiens full length insert cDNA clone ZE02D01.
JD308598 - Sequence 289622 from Patent EP1572962.
JD327360 - Sequence 308384 from Patent EP1572962.
JD439073 - Sequence 420097 from Patent EP1572962.
JD083492 - Sequence 64516 from Patent EP1572962.
JD153144 - Sequence 134168 from Patent EP1572962.
JD523593 - Sequence 504617 from Patent EP1572962.
S67247 - smooth muscle myosin heavy chain isoform SMemb [human, umbilical cord, fetal aorta, mRNA Partial, 971 nt].
JD111274 - Sequence 92298 from Patent EP1572962.
JD469867 - Sequence 450891 from Patent EP1572962.
JD055332 - Sequence 36356 from Patent EP1572962.
JD552040 - Sequence 533064 from Patent EP1572962.
JD292729 - Sequence 273753 from Patent EP1572962.
JD334631 - Sequence 315655 from Patent EP1572962.
JD233947 - Sequence 214971 from Patent EP1572962.
JD491134 - Sequence 472158 from Patent EP1572962.
DQ580154 - Homo sapiens piRNA piR-48266, complete sequence.
DQ925667 - Homo sapiens clone 1-3 nonmuscle myosin heavy chain 10 (MYH10) mRNA, partial cds, alternatively spliced.
JD315557 - Sequence 296581 from Patent EP1572962.
JD184281 - Sequence 165305 from Patent EP1572962.
JD080376 - Sequence 61400 from Patent EP1572962.
U15618 - Human nonmuscle myosin heavy chain-B mRNA, partial cds.
JD043396 - Sequence 24420 from Patent EP1572962.
JD469455 - Sequence 450479 from Patent EP1572962.
JD042448 - Sequence 23472 from Patent EP1572962.
AB621820 - Homo sapiens MYH10 mRNA for myosin-10, partial cds, clone: HP08316-RBdS007C12.
JD332769 - Sequence 313793 from Patent EP1572962.
U34304 - Human nonmuscle myosin heavy chain IIB mRNA, partial cds.
JD348620 - Sequence 329644 from Patent EP1572962.
JD197357 - Sequence 178381 from Patent EP1572962.
JD111043 - Sequence 92067 from Patent EP1572962.
JD103585 - Sequence 84609 from Patent EP1572962.
JD140900 - Sequence 121924 from Patent EP1572962.
JD443237 - Sequence 424261 from Patent EP1572962.
JD044426 - Sequence 25450 from Patent EP1572962.
JD038909 - Sequence 19933 from Patent EP1572962.
JD502784 - Sequence 483808 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04530 - Tight junction
hsa04810 - Regulation of actin cytoskeleton
hsa05416 - Viral myocarditis

Reactome (by CSHL, EBI, and GO)

Protein P35580 (Reactome details) participates in the following event(s):

R-HSA-419197 Myosin regulatory light chain phosphorylation by ROCK
R-HSA-3928616 Activated ROCK phosphorylates MRLCs
R-HSA-5668932 PAK2 phosphorylates myosin regulatory light chain (MRLC)
R-HSA-5668978 MYLK (MLCK) phosphorylates MRLCs of the non-muscle myosin II complex
R-HSA-5671919 Activated CIT phosphorylates MRLCs
R-HSA-419232 Myosin phosphatase dephosphorylates myosin regulatory light chain
R-HSA-416572 Sema4D induced cell migration and growth-cone collapse
R-HSA-5627117 RHO GTPases Activate ROCKs
R-HSA-3928663 EPHA-mediated growth cone collapse
R-HSA-5627123 RHO GTPases activate PAKs
R-HSA-5625900 RHO GTPases activate CIT
R-HSA-5625740 RHO GTPases activate PKNs
R-HSA-400685 Sema4D in semaphorin signaling
R-HSA-195258 RHO GTPase Effectors
R-HSA-2682334 EPH-Ephrin signaling
R-HSA-373755 Semaphorin interactions
R-HSA-194315 Signaling by Rho GTPases
R-HSA-422475 Axon guidance
R-HSA-162582 Signal Transduction
R-HSA-1266738 Developmental Biology

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000269243.1, ENST00000269243.2, ENST00000269243.3, ENST00000269243.4, ENST00000269243.5, ENST00000269243.6, ENST00000269243.7, MYH10_HUMAN, NM_005964, P35580, Q12989, Q149N3, Q149N4, Q16087, Q6PK16, uc002gll.1, uc002gll.2, uc002gll.3, uc002gll.4, uc002gll.5
UCSC ID: ENST00000269243.8
RefSeq Accession: NM_001256095
Protein: P35580 (aka MYH10_HUMAN or MYHA_HUMAN)
CCDS: CCDS11144.1, CCDS58515.1, CCDS73984.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.