Human Gene PIH1D2 (ENST00000280350.9) Description and Page Index
  Description: Homo sapiens PIH1 domain containing 2 (PIH1D2), transcript variant 1, mRNA. (from RefSeq NM_138789)
Gencode Transcript: ENST00000280350.9
Gencode Gene: ENSG00000150773.11
Transcript (Including UTRs)
   Position: hg38 chr11:112,067,798-112,074,267 Size: 6,470 Total Exon Count: 6 Strand: -
Coding Region
   Position: hg38 chr11:112,067,871-112,073,174 Size: 5,304 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2021-01-14 15:32:12

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:112,067,798-112,074,267)mRNA (may differ from genome)Protein (315 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaBioGPSCGAP
EnsemblEntrez GeneExonPrimerGeneCardsHGNCHPRD
LynxMGIneXtProtPubMedUniProtKB

-  Comments and Description Text from UniProtKB
  ID: PIHD2_HUMAN
DESCRIPTION: RecName: Full=PIH1 domain-containing protein 2;
SIMILARITY: Belongs to the PIH1 family.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 31.60 RPKM in Testis
Total median expression: 61.75 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -99.00319-0.310 Picture PostScript Text
3' UTR -12.4073-0.170 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR012981 - PIH

Pfam Domains:
PF08190 - pre-RNA processing PIH1/Nop17

ModBase Predicted Comparative 3D Structure on Q8WWB5
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0017160 Ral GTPase binding


-  Descriptions from all associated GenBank mRNAs
  HQ448182 - Synthetic construct Homo sapiens clone IMAGE:100071576; CCSB007404_03 PIH1 domain containing 2 (PIH1D2) gene, encodes complete protein.
KJ895351 - Synthetic construct Homo sapiens clone ccsbBroadEn_04745 PIH1D2 gene, encodes complete protein.
BC019238 - Homo sapiens PIH1 domain containing 2, mRNA (cDNA clone MGC:23989 IMAGE:3935322), complete cds.
CU676398 - Synthetic construct Homo sapiens gateway clone IMAGE:100023388 5' read PIH1D2 mRNA.
AK300496 - Homo sapiens cDNA FLJ60158 complete cds.
JD493003 - Sequence 474027 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000280350.1, ENST00000280350.2, ENST00000280350.3, ENST00000280350.4, ENST00000280350.5, ENST00000280350.6, ENST00000280350.7, ENST00000280350.8, NM_138789, PIHD2_HUMAN, Q8WWB5, uc001pmp.1, uc001pmp.2, uc001pmp.3, uc001pmp.4, uc001pmp.5, uc001pmp.6
UCSC ID: ENST00000280350.9
RefSeq Accession: NM_138789
Protein: Q8WWB5 (aka PIHD2_HUMAN)
CCDS: CCDS8355.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.