Human Gene PKNOX2 (ENST00000298282.14) Description and Page Index
  Description: Homo sapiens PBX/knotted 1 homeobox 2 (PKNOX2), transcript variant 28, non-coding RNA. (from RefSeq NR_168084)
RefSeq Summary (NM_001382323): Homeodomain proteins are sequence-specific transcription factors that share a highly conserved DNA-binding domain and play fundamental roles in cell proliferation, differentiation, and death. PKNOX2 belongs to the TALE (3-amino acid loop extension) class of homeodomain proteins characterized by a 3-amino acid extension between alpha helices 1 and 2 within the homeodomain (Imoto et al., 2001 [PubMed 11549286]).[supplied by OMIM, Oct 2009].
Gencode Transcript: ENST00000298282.14
Gencode Gene: ENSG00000165495.16
Transcript (Including UTRs)
   Position: hg38 chr11:125,164,751-125,433,389 Size: 268,639 Total Exon Count: 13 Strand: +
Coding Region
   Position: hg38 chr11:125,351,306-125,431,392 Size: 80,087 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2021-01-14 15:32:12

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr11:125,164,751-125,433,389)mRNA (may differ from genome)Protein (472 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Homeobox protein PKNOX2; AltName: Full=Homeobox protein PREP-2; AltName: Full=PBX/knotted homeobox 2;
SIMILARITY: Belongs to the TALE/MEIS homeobox family.
SIMILARITY: Contains 1 homeobox DNA-binding domain.
SEQUENCE CAUTION: Sequence=BAB83665.1; Type=Erroneous initiation;

-  MalaCards Disease Associations
  MalaCards Gene Search: PKNOX2
Diseases sorted by gene-association score: substance dependence (3), hydrolethalus syndrome (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 13.85 RPKM in Brain - Cortex
Total median expression: 149.10 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -74.40226-0.329 Picture PostScript Text
3' UTR -714.001997-0.358 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR008422 - Homeobox_KN_domain
IPR001356 - Homeodomain
IPR009057 - Homeodomain-like

Pfam Domains:
PF05920 - Homeobox KN domain

ModBase Predicted Comparative 3D Structure on Q96KN3
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologGenome Browser
Gene Details    Gene Details
Gene Sorter    Gene Sorter
Protein SequenceProtein Sequence   Protein Sequence
AlignmentAlignment   Alignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003785 actin monomer binding
GO:0043565 sequence-specific DNA binding
GO:0051015 actin filament binding

Biological Process:
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0015629 actin cytoskeleton
GO:0015630 microtubule cytoskeleton
GO:0045171 intercellular bridge

-  Descriptions from all associated GenBank mRNAs
  AK295857 - Homo sapiens cDNA FLJ57996 complete cds, highly similar to Homeobox protein PKNOX2.
AK316268 - Homo sapiens cDNA, FLJ79167 complete cds, highly similar to Homeobox protein PKNOX2.
BC045626 - Homo sapiens PBX/knotted 1 homeobox 2, mRNA (cDNA clone MGC:39607 IMAGE:5261106), complete cds.
AK056506 - Homo sapiens cDNA FLJ31944 fis, clone NT2RP7006887.
AK316001 - Homo sapiens cDNA, FLJ78900 complete cds, highly similar to Homeobox protein PKNOX2.
AK298999 - Homo sapiens cDNA FLJ58605 complete cds, highly similar to Homeobox protein PKNOX2.
BX648615 - Homo sapiens mRNA; cDNA DKFZp686G20229 (from clone DKFZp686G20229).
AB464002 - Synthetic construct DNA, clone: pF1KB8291, Homo sapiens PKNOX2 gene for PBX/knotted 1 homeobox 2, without stop codon, in Flexi system.
EU446845 - Synthetic construct Homo sapiens clone IMAGE:100070146; IMAGE:100012054; FLH257490.01L PBX/knotted 1 homeobox 2 (PKNOX2) gene, encodes complete protein.
EU831765 - Synthetic construct Homo sapiens clone HAIB:100066794; DKFZo008B0921 PBX/knotted 1 homeobox 2 protein (PKNOX2) gene, encodes complete protein.
EU831843 - Synthetic construct Homo sapiens clone HAIB:100066872; DKFZo004B0922 PBX/knotted 1 homeobox 2 protein (PKNOX2) gene, encodes complete protein.
JD052704 - Sequence 33728 from Patent EP1572962.
AB065001 - Homo sapiens mRNA for PKNOX2, complete cds.
AK023136 - Homo sapiens cDNA FLJ13074 fis, clone NT2RP3001855, moderately similar to HOMEOBOX PROTEIN PKNOX1.
AJ417081 - Homo sapiens mRNA for PREP2 protein.
AL512682 - Homo sapiens mRNA; cDNA DKFZp547B212 (from clone DKFZp547B212).
AK023792 - Homo sapiens cDNA FLJ13730 fis, clone PLACE3000136.
JD390290 - Sequence 371314 from Patent EP1572962.
JD076255 - Sequence 57279 from Patent EP1572962.
JD404928 - Sequence 385952 from Patent EP1572962.
JD038273 - Sequence 19297 from Patent EP1572962.
JD536040 - Sequence 517064 from Patent EP1572962.
JD519918 - Sequence 500942 from Patent EP1572962.
JD414022 - Sequence 395046 from Patent EP1572962.
JD269423 - Sequence 250447 from Patent EP1572962.
JD148580 - Sequence 129604 from Patent EP1572962.
JD214891 - Sequence 195915 from Patent EP1572962.
JD435985 - Sequence 417009 from Patent EP1572962.
JD449095 - Sequence 430119 from Patent EP1572962.
JD531613 - Sequence 512637 from Patent EP1572962.
JD176118 - Sequence 157142 from Patent EP1572962.
JD449615 - Sequence 430639 from Patent EP1572962.
JD354970 - Sequence 335994 from Patent EP1572962.
JD340081 - Sequence 321105 from Patent EP1572962.
DQ596697 - Homo sapiens piRNA piR-34763, complete sequence.
JD173287 - Sequence 154311 from Patent EP1572962.
JD177109 - Sequence 158133 from Patent EP1572962.
JD485282 - Sequence 466306 from Patent EP1572962.
JD530057 - Sequence 511081 from Patent EP1572962.
JD328523 - Sequence 309547 from Patent EP1572962.
JD363313 - Sequence 344337 from Patent EP1572962.
JD088290 - Sequence 69314 from Patent EP1572962.
JD385058 - Sequence 366082 from Patent EP1572962.
JD187350 - Sequence 168374 from Patent EP1572962.
JD449768 - Sequence 430792 from Patent EP1572962.
JD437314 - Sequence 418338 from Patent EP1572962.
JD289900 - Sequence 270924 from Patent EP1572962.
JD215890 - Sequence 196914 from Patent EP1572962.
JD178580 - Sequence 159604 from Patent EP1572962.
JD539751 - Sequence 520775 from Patent EP1572962.
JD438652 - Sequence 419676 from Patent EP1572962.
JD402797 - Sequence 383821 from Patent EP1572962.
JD146031 - Sequence 127055 from Patent EP1572962.
JD566412 - Sequence 547436 from Patent EP1572962.
JD100729 - Sequence 81753 from Patent EP1572962.
JD057683 - Sequence 38707 from Patent EP1572962.
JD559232 - Sequence 540256 from Patent EP1572962.
JD251404 - Sequence 232428 from Patent EP1572962.
JD288638 - Sequence 269662 from Patent EP1572962.
JD243107 - Sequence 224131 from Patent EP1572962.
JD498117 - Sequence 479141 from Patent EP1572962.
JD123253 - Sequence 104277 from Patent EP1572962.
JD544166 - Sequence 525190 from Patent EP1572962.
JD436416 - Sequence 417440 from Patent EP1572962.
JD365870 - Sequence 346894 from Patent EP1572962.
JD055522 - Sequence 36546 from Patent EP1572962.
JD121956 - Sequence 102980 from Patent EP1572962.
JD281562 - Sequence 262586 from Patent EP1572962.
JD054966 - Sequence 35990 from Patent EP1572962.
JD236308 - Sequence 217332 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000298282.1, ENST00000298282.10, ENST00000298282.11, ENST00000298282.12, ENST00000298282.13, ENST00000298282.2, ENST00000298282.3, ENST00000298282.4, ENST00000298282.5, ENST00000298282.6, ENST00000298282.7, ENST00000298282.8, ENST00000298282.9, NR_168084, PKNX2_HUMAN, PREP2, Q63HL6, Q86XD1, Q96KN3, uc001qbu.1, uc001qbu.2, uc001qbu.3, uc001qbu.4, uc001qbu.5
UCSC ID: ENST00000298282.14
RefSeq Accession: NM_001382323
Protein: Q96KN3 (aka PKNX2_HUMAN or PNX2_HUMAN)
CCDS: CCDS41730.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.