Human Gene STIP1 (ENST00000305218.8) Description and Page Index
  Description: Homo sapiens stress induced phosphoprotein 1 (STIP1), transcript variant 2, mRNA. (from RefSeq NM_006819)
RefSeq Summary (NM_006819): STIP1 is an adaptor protein that coordinates the functions of HSP70 (see HSPA1A; MIM 140550) and HSP90 (see HSP90AA1; MIM 140571) in protein folding. It is thought to assist in the transfer of proteins from HSP70 to HSP90 by binding both HSP90 and substrate-bound HSP70. STIP1 also stimulates the ATPase activity of HSP70 and inhibits the ATPase activity of HSP90, suggesting that it regulates both the conformations and ATPase cycles of these chaperones (Song and Masison, 2005 [PubMed 16100115]).[supplied by OMIM, Jul 2009].
Gencode Transcript: ENST00000305218.8
Gencode Gene: ENSG00000168439.16
Transcript (Including UTRs)
   Position: hg38 chr11:64,186,115-64,204,543 Size: 18,429 Total Exon Count: 14 Strand: +
Coding Region
   Position: hg38 chr11:64,186,262-64,204,126 Size: 17,865 Coding Exon Count: 14 

Page IndexSequence and LinksCTDRNA-Seq ExpressionMicroarray ExpressionRNA Structure
Other SpeciesmRNA DescriptionsPathwaysOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr11:64,186,115-64,204,543)mRNA (may differ from genome)Protein (543 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 82.95 RPKM in Testis
Total median expression: 1431.28 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -59.90147-0.407 Picture PostScript Text
3' UTR -145.80417-0.350 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologGenome Browser
Gene Details    Gene Details
Gene Sorter    Gene Sorter
 RGDEnsembl  SGD
 Protein Sequence   Protein Sequence
 Alignment   Alignment

-  Descriptions from all associated GenBank mRNAs
  DQ893295 - Synthetic construct clone IMAGE:100005925; FLH199489.01X; RZPDo839D0982D stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing protein) (STIP1) gene, encodes complete protein.
EU176746 - Synthetic construct Homo sapiens clone IMAGE:100011564; FLH197009.01L; RZPDo839C01256D stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing protein) (STIP1) gene, encodes complete protein.
BC039299 - Homo sapiens stress-induced-phosphoprotein 1, mRNA (cDNA clone MGC:39562 IMAGE:4830381), complete cds.
AK291555 - Homo sapiens cDNA FLJ76863 complete cds, highly similar to Homo sapiens stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing protein) (STIP1), mRNA.
BC002987 - Homo sapiens stress-induced-phosphoprotein 1, mRNA (cDNA clone MGC:3516 IMAGE:2823157), complete cds.
FJ224350 - Homo sapiens epididymis secretory sperm binding protein Li 94n (HEL-S-94n) mRNA, complete cds.
M86752 - Human transformation-sensitive protein (IEF SSP 3521) mRNA, complete cds.
AK297319 - Homo sapiens cDNA FLJ54451 complete cds, highly similar to Stress-induced-phosphoprotein 1.
AK225736 - Homo sapiens mRNA for stress-induced-phosphoprotein 1 variant, clone: TST08027.
CU678328 - Synthetic construct Homo sapiens gateway clone IMAGE:100020289 5' read STIP1 mRNA.
AB385013 - Synthetic construct DNA, clone: pF1KB5012, Homo sapiens STIP1 gene for stress-induced-phosphoprotein 1, complete cds, without stop codon, in Flexi system.
BT020010 - Homo sapiens stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing protein) mRNA, complete cds.
BT020011 - Homo sapiens stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing protein) mRNA, complete cds.
KJ893183 - Synthetic construct Homo sapiens clone ccsbBroadEn_02577 STIP1 gene, encodes complete protein.
CR536512 - Homo sapiens full open reading frame cDNA clone RZPDo834C0722D for gene STIP1, stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing protein); complete cds, incl. stopcodon.
GQ891364 - Homo sapiens clone HEL-S-152l epididymis secretory sperm binding protein mRNA, complete cds.
JD539027 - Sequence 520051 from Patent EP1572962.
JD178272 - Sequence 159296 from Patent EP1572962.
JD067799 - Sequence 48823 from Patent EP1572962.
JD452329 - Sequence 433353 from Patent EP1572962.
JD141628 - Sequence 122652 from Patent EP1572962.
JD271302 - Sequence 252326 from Patent EP1572962.
JD458586 - Sequence 439610 from Patent EP1572962.
JD129866 - Sequence 110890 from Patent EP1572962.
JD404987 - Sequence 386011 from Patent EP1572962.
JD262724 - Sequence 243748 from Patent EP1572962.
JD489706 - Sequence 470730 from Patent EP1572962.
JD554135 - Sequence 535159 from Patent EP1572962.
JD147748 - Sequence 128772 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa05020 - Prion diseases

-  Other Names for This Gene
  Alternate Gene Symbols: NM_006819, uc001nyk.1, uc001nyk.2, V9HW72
UCSC ID: uc001nyk.2
RefSeq Accession: NM_006819
CCDS: CCDS8058.1, CCDS60828.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.