Human Gene STIP1 (ENST00000305218.8) Description and Page Index
Description: Homo sapiens stress induced phosphoprotein 1 (STIP1), transcript variant 2, mRNA. (from RefSeq NM_006819) RefSeq Summary (NM_006819): STIP1 is an adaptor protein that coordinates the functions of HSP70 (see HSPA1A; MIM 140550) and HSP90 (see HSP90AA1; MIM 140571) in protein folding. It is thought to assist in the transfer of proteins from HSP70 to HSP90 by binding both HSP90 and substrate-bound HSP70. STIP1 also stimulates the ATPase activity of HSP70 and inhibits the ATPase activity of HSP90, suggesting that it regulates both the conformations and ATPase cycles of these chaperones (Song and Masison, 2005 [PubMed 16100115]).[supplied by OMIM, Jul 2009]. Gencode Transcript: ENST00000305218.8 Gencode Gene: ENSG00000168439.16 Transcript (Including UTRs) Position: hg38 chr11:64,186,115-64,204,543 Size: 18,429 Total Exon Count: 14 Strand: + Coding Region Position: hg38 chr11:64,186,262-64,204,126 Size: 17,865 Coding Exon Count: 14
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.