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Human Gene GPR171 (ENST00000309180.6) from GENCODE V49
  Description: G protein-coupled receptor 171 (from RefSeq NM_013308.4)
Gencode Transcript: ENST00000309180.6
Gencode Gene: ENSG00000174946.7
Transcript (Including UTRs)
   Position: hg38 chr3:151,197,832-151,203,216 Size: 5,385 Total Exon Count: 3 Strand: -
Coding Region
   Position: hg38 chr3:151,198,427-151,199,386 Size: 960 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2025-09-17 13:57:07

-  Comments and Description Text from UniProtKB
  ID: GP171_HUMAN
DESCRIPTION: RecName: Full=Probable G-protein coupled receptor 171; AltName: Full=G-protein coupled receptor H963;
FUNCTION: Orphan receptor.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 6.11 RPKM in Spleen
Total median expression: 31.42 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
 
Expression ratio colors:

GNF Expression Atlas 2 Data from U133A and GNF1H Chips

      
      
      
     
    
     
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -65.20255-0.256 Picture PostScript Text
3' UTR -94.00595-0.158 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR017452 - GPCR_Rhodpsn_supfam
IPR002286 - P2_purnocptor

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)

ModBase Predicted Comparative 3D Structure on O14626
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0045028 G-protein coupled purinergic nucleotide receptor activity

Biological Process:
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway
GO:0045638 negative regulation of myeloid cell differentiation

Cellular Component:
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  BC036815 - Homo sapiens G protein-coupled receptor 171, mRNA (cDNA clone MGC:46113 IMAGE:5747378), complete cds.
JD298144 - Sequence 279168 from Patent EP1572962.
JD504173 - Sequence 485197 from Patent EP1572962.
AF002986 - Homo sapiens platelet activating receptor homolog (H963) mRNA, complete cds.
JD314602 - Sequence 295626 from Patent EP1572962.
DQ890941 - Synthetic construct clone IMAGE:100003571; FLH167734.01X; RZPDo839E0890D G protein-coupled receptor 171 (GPR171) gene, encodes complete protein.
KJ898742 - Synthetic construct Homo sapiens clone ccsbBroadEn_08136 GPR171 gene, encodes complete protein.
DQ894101 - Synthetic construct Homo sapiens clone IMAGE:100008561; FLH167730.01L; RZPDo839E0889D G protein-coupled receptor 171 (GPR171) gene, encodes complete protein.
CU691428 - Synthetic construct Homo sapiens gateway clone IMAGE:100016700 5' read GPR171 mRNA.
JD213865 - Sequence 194889 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: D3DNJ4, ENST00000309180.1, ENST00000309180.2, ENST00000309180.3, ENST00000309180.4, ENST00000309180.5, GP171_HUMAN, GPR171 , H963, NM_013308, O14626, Q8IV06, uc003eyq.1, uc003eyq.2, uc003eyq.3, uc003eyq.4, uc003eyq.5, uc003eyq.6
UCSC ID: ENST00000309180.6
RefSeq Accession: NM_013308.4
Protein: O14626 (aka GP171_HUMAN or G171_HUMAN)
CCDS: CCDS3155.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.