Human Gene DHRS4 (ENST00000313250.10) Description and Page Index
  Description: Homo sapiens dehydrogenase/reductase 4 (DHRS4), transcript variant 1, mRNA. (from RefSeq NM_021004)
Gencode Transcript: ENST00000313250.10
Gencode Gene: ENSG00000157326.19
Transcript (Including UTRs)
   Position: hg38 chr14:23,953,770-23,969,279 Size: 15,510 Total Exon Count: 8 Strand: +
Coding Region
   Position: hg38 chr14:23,953,789-23,968,871 Size: 15,083 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathways
Other NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr14:23,953,770-23,969,279)mRNA (may differ from genome)Protein (278 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
ReactomeStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Dehydrogenase/reductase SDR family member 4; EC=; AltName: Full=NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenase; Short=CR; Short=PHCR; AltName: Full=NADPH-dependent retinol dehydrogenase/reductase; Short=NRDR; Short=humNRDR; AltName: Full=Peroxisomal short-chain alcohol dehydrogenase; Short=PSCD; AltName: Full=SCAD-SRL; AltName: Full=Short-chain dehydrogenase/reductase family member 4;
FUNCTION: Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co- factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity).
SUBUNIT: Homotetramer (By similarity).
SUBCELLULAR LOCATION: Peroxisome. Note=Isoform 1 is peroxisomal, while isoform 4 is not.
TISSUE SPECIFICITY: Isoform 1 is predominantly expressed in normal cervix (at protein level). Isoform 4 is expressed in some neoplastic cervical tissues, but not in normal cervix (at protein level). Isoform 5 and isoform 6 are expressed in a few neoplastic cervical tissues.
MISCELLANEOUS: Inhibited by kaempferol, quercetin, genistein and myristic acid (By similarity).
SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
SEQUENCE CAUTION: Sequence=AAD02292.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAL61824.2; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB18775.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAG37057.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 21.61 RPKM in Liver
Total median expression: 491.71 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR 0.00190.000 Picture PostScript Text
3' UTR -143.50408-0.352 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002198 - DH_sc/Rdtase_SDR
IPR002347 - Glc/ribitol_DH
IPR016040 - NAD(P)-bd_dom
IPR020904 - Sc_DH/Rdtase_CS

Protein Data Bank (PDB) 3-D Structure
MuPIT help

- X-ray MuPIT

ModBase Predicted Comparative 3D Structure on Q9BTZ2
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000253 3-keto sterol reductase activity
GO:0004090 carbonyl reductase (NADPH) activity
GO:0005102 receptor binding
GO:0016491 oxidoreductase activity
GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
GO:0018455 alcohol dehydrogenase [NAD(P)+] activity
GO:0052650 NADP-retinol dehydrogenase activity

Biological Process:
GO:0006066 alcohol metabolic process
GO:0006625 protein targeting to peroxisome
GO:0008202 steroid metabolic process
GO:0042180 cellular ketone metabolic process
GO:0042572 retinol metabolic process
GO:0051262 protein tetramerization
GO:0055114 oxidation-reduction process

Cellular Component:
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005777 peroxisome
GO:0005778 peroxisomal membrane
GO:0005782 peroxisomal matrix
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol

-  Descriptions from all associated GenBank mRNAs
  AY616182 - Homo sapiens NADP(H)-dependent retinol dehydrogenase A2 isoform (DHRS4) mRNA, complete cds.
DQ344810 - Homo sapiens NADP(H)-dependent retinol dehydrogenase/reductase short isoform (DHRS4) mRNA, complete cds.
AY358638 - Homo sapiens clone DNA35672 SCAD-SRL (UNQ851) mRNA, complete cds.
AF064256 - Homo sapiens Hep27-like protein mRNA, complete cds.
AF044127 - Homo sapiens peroxisomal short-chain alcohol dehydrogenase (SCAD-SRL) mRNA, complete cds.
AK001870 - Homo sapiens cDNA FLJ11008 fis, clone PLACE1003100, moderately similar to HEP27 PROTEIN.
AB045131 - Homo sapiens humNRDR mRNA for NADPH-dependent retinol dehydrogenase/reductase, complete cds.
AY071856 - Homo sapiens NADP-dependent retinol dehydrogenase short isoform mRNA, complete cds.
BC003019 - Homo sapiens dehydrogenase/reductase (SDR family) member 4, mRNA (cDNA clone MGC:4052 IMAGE:2822884), complete cds.
AK308436 - Homo sapiens cDNA, FLJ98384.
DQ325464 - Homo sapiens NADP(H)-dependent retinol dehydrogenase/reductase B1 isoform (DHRS4) mRNA, complete cds, alternatively spliced.
AK314448 - Homo sapiens cDNA, FLJ95247, highly similar to Homo sapiens dehydrogenase/reductase (SDR family) member 4 (DHRS4), mRNA.
KJ904664 - Synthetic construct Homo sapiens clone ccsbBroadEn_14058 DHRS4-like gene, encodes complete protein.
AK301201 - Homo sapiens cDNA FLJ54180 complete cds, highly similar to Homo sapiens dehydrogenase/reductase (SDR family) member 4 (DHRS4), mRNA.
DL491728 - Novel nucleic acids.
DL490308 - Novel nucleic acids.
DQ338571 - Homo sapiens NADP(H)-dependent retinol dehydrogenase/reductase B2 isoform (DHRS4) mRNA, partial cds, alternatively spliced.
AK021587 - Homo sapiens cDNA FLJ11525 fis, clone HEMBA1002552.
JD424913 - Sequence 405937 from Patent EP1572962.
JD098526 - Sequence 79550 from Patent EP1572962.
JD294480 - Sequence 275504 from Patent EP1572962.
JD113247 - Sequence 94271 from Patent EP1572962.
JD099644 - Sequence 80668 from Patent EP1572962.
JD071377 - Sequence 52401 from Patent EP1572962.
JD416114 - Sequence 397138 from Patent EP1572962.
JD253629 - Sequence 234653 from Patent EP1572962.
JD050550 - Sequence 31574 from Patent EP1572962.
JD216314 - Sequence 197338 from Patent EP1572962.
JD312958 - Sequence 293982 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa00830 - Retinol metabolism
hsa01100 - Metabolic pathways
hsa04146 - Peroxisome

BioCyc Knowledge Library
PWY-6857 - retinol biosynthesis
PWY-6861 - the visual cycle I (vertebrates)

Reactome (by CSHL, EBI, and GO)

Protein Q9BTZ2 (Reactome details) participates in the following event(s):

R-HSA-9033233 PEX5S,L binds cargo proteins containing PTS1
R-HSA-5419165 RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL
R-HSA-9033236 PEX5S,L:Cargo binds PEX13:PEX14 of PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Complex)
R-HSA-9033241 Peroxisomal protein import
R-HSA-5365859 RA biosynthesis pathway
R-HSA-392499 Metabolism of proteins
R-HSA-5362517 Signaling by Retinoic Acid
R-HSA-9006931 Signaling by Nuclear Receptors
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: B2RB10, B7WNS9, D3YTB8, DHRS4_HUMAN, NM_021004, O95162, Q20CR0, Q2LC19, Q2LE81, Q58IU4, Q6E0Y1, Q6UWU3, Q71UQ6, Q8TD03, Q9BTZ2, Q9H3N5, Q9NV08, uc001wla.1, uc001wla.2, uc001wla.3, uc001wla.4, uc001wla.5, uc001wla.6, UNQ851/PRO1800
UCSC ID: uc001wla.6
RefSeq Accession: NM_021004
Protein: Q9BTZ2 (aka DHRS4_HUMAN or DHS4_HUMAN)
CCDS: CCDS9605.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.