Human Gene ESR1 (ENST00000338799.9) Description and Page Index
  Description: Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA- binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF- kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA- binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Isoform 3 is involved in activation of NOS3 and endothelial nitric oxide production. Isoforms lacking one or several functional domains are thought to modulate transcriptional activity by competitive ligand or DNA binding and/or heterodimerization with the full length receptor. Isoform 3 can bind to ERE and inhibit isoform 1. (from UniProt P03372)
RefSeq Summary (NM_001122741): This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Mar 2014].
Gencode Transcript: ENST00000338799.9
Gencode Gene: ENSG00000091831.23
Transcript (Including UTRs)
   Position: hg38 chr6:151,804,431-152,099,053 Size: 294,623 Total Exon Count: 9 Strand: +
Coding Region
   Position: hg38 chr6:151,807,913-152,098,966 Size: 291,054 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:151,804,431-152,099,053)mRNA (may differ from genome)Protein (595 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblExonPrimerGeneCardsHGNCLynx
MGIneXtProtPubMedReactomeStanford SOURCEUniProtKB
Wikipedia

-  Comments and Description Text from UniProtKB
  ID: ESR1_HUMAN
DESCRIPTION: RecName: Full=Estrogen receptor; Short=ER; AltName: Full=ER-alpha; AltName: Full=Estradiol receptor; AltName: Full=Nuclear receptor subfamily 3 group A member 1;
FUNCTION: Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA- binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF- kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA- binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Isoform 3 is involved in activation of NOS3 and endothelial nitric oxide production. Isoforms lacking one or several functional domains are thought to modulate transcriptional activity by competitive ligand or DNA binding and/or heterodimerization with the full length receptor. Isoform 3 can bind to ERE and inhibit isoform 1.
SUBUNIT: Binds DNA as a homodimer. Can form a heterodimer with ESR2. Isoform 3 can probably homodimerize or heterodimerize with isoform 1 and ESR2. Interacts with FOXC2, MAP1S, SLC30A9, UBE1C and NCOA3 coactivator (By similarity). Interacts with EP300; the interaction is estrogen-dependent and enhanced by CITED1. Interacts with CITED1; the interaction is estrogen-dependent. Interacts with NCOA5 and NCOA6 coactivators. Interacts with NCOA7; the interaction is a ligand-inducible. Interacts with PHB2, PELP1 and UBE1C. Interacts with AKAP13. Interacts with CUEDC2. Interacts with KDM5A. Interacts with SMARD1. Interacts with HEXIM1. Interacts with PBXIP1. Interaction with MUC1 is stimulated by 7 beta-estradiol (E2) and enhances ERS1-mediated transcription. Interacts with DNTTIP2, FAM120B and UIMC1. Interacts with isoform 4 of TXNRD1. Interacts with MLL2. Interacts with ATAD2 and this interaction is enhanced by estradiol. Interacts with KIF18A and LDB1. Interacts with RLIM (via C-terminus). Interacts with MACROD1. Interacts with SH2D4A and PLCG. Interaction with SH2D4A blocks binding to PLCG and inhibits estrogen-induced cell proliferation. Interacts with DYNLL1. Interacts with CCDC62 in the presence of estradiol/E2; this interaction seems to enhance the transcription of target genes. Interacts with NR2C1; the interaction prevents homodimerization of ESR1 and suppresses its transcriptional activity and cell growth. Interacts with DYX1C1. Interacts with PRMT2. Interacts with PI3KR1 or PI3KR2, SRC and PTK2/FAK1. Interacts with RBFOX2. Interacts with STK3/MST2 only in the presence of SAV1 and vice-versa. Binds to CSNK1D. Interacts with NCOA2; NCOA2 can interact with ESE1 AF-1 and AF-2 domains simultaneously and mediate their transcriptional synergy. Interacts with DDX5. Interacts with NCOA1; the interaction seems to require a self-association of N-terminal and C-terminal regions. Interacts with ZNF366, DDX17, NFKB1, RELA, SP1 and SP3. Interacts with NRIP1 (By similarity).
INTERACTION: Self; NbExp=8; IntAct=EBI-78473, EBI-78473; Q12802:AKAP13; NbExp=3; IntAct=EBI-78473, EBI-1373806; Q9Y294:ASF1A; NbExp=2; IntAct=EBI-78473, EBI-749553; Q8IXJ9:ASXL1; NbExp=2; IntAct=EBI-78473, EBI-1646500; P59598:Asxl1 (xeno); NbExp=2; IntAct=EBI-78473, EBI-5743705; P62952:BLCAP; NbExp=2; IntAct=EBI-78473, EBI-3895726; P38398:BRCA1; NbExp=12; IntAct=EBI-78473, EBI-349905; P20290-2:BTF3; NbExp=5; IntAct=EBI-78473, EBI-1054703; Q99966:CITED1; NbExp=3; IntAct=EBI-78473, EBI-2624951; Q9H467:CUEDC2; NbExp=2; IntAct=EBI-78473, EBI-1248228; Q92841:DDX17; NbExp=7; IntAct=EBI-78473, EBI-746012; P17844:DDX5; NbExp=8; IntAct=EBI-78473, EBI-351962; O00429:DNM1L; NbExp=2; IntAct=EBI-78473, EBI-724571; P00533:EGFR; NbExp=4; IntAct=EBI-4309277, EBI-297353; Q12778:FOXO1; NbExp=2; IntAct=EBI-78473, EBI-1108782; O00165:HAX1; NbExp=2; IntAct=EBI-78473, EBI-357001; P05627:Jun (xeno); NbExp=6; IntAct=EBI-78473, EBI-764369; Q9BQ69:MACROD1; NbExp=4; IntAct=EBI-78473, EBI-5324932; Q00987:MDM2; NbExp=2; IntAct=EBI-78473, EBI-389668; O14686:MLL2; NbExp=3; IntAct=EBI-78473, EBI-996065; P60660:MYL6; NbExp=3; IntAct=EBI-78473, EBI-300817; Q15788:NCOA1; NbExp=5; IntAct=EBI-78473, EBI-455189; Q15596:NCOA2; NbExp=8; IntAct=EBI-78473, EBI-81236; Q9Y6Q9:NCOA3; NbExp=2; IntAct=EBI-78473, EBI-81196; Q9JLI4:Ncoa6 (xeno); NbExp=2; IntAct=EBI-78473, EBI-286271; Q9UN36:NDRG2; NbExp=2; IntAct=EBI-78473, EBI-3895741; P19838:NFKB1; NbExp=3; IntAct=EBI-78473, EBI-697771; Q96AQ6:PBXIP1; NbExp=9; IntAct=EBI-78473, EBI-740845; Q99623:PHB2; NbExp=4; IntAct=EBI-78473, EBI-358348; P53041:PPP5C; NbExp=4; IntAct=EBI-78473, EBI-716663; P55345:PRMT2; NbExp=5; IntAct=EBI-78473, EBI-78458; P60763:RAC3; NbExp=5; IntAct=EBI-78473, EBI-767084; O43251:RBFOX2; NbExp=4; IntAct=EBI-78473, EBI-746056; Q04206:RELA; NbExp=7; IntAct=EBI-78473, EBI-73886; Q14151:SAFB2; NbExp=2; IntAct=EBI-78473, EBI-352869; Q96HI0:SENP5; NbExp=2; IntAct=EBI-78473, EBI-3895753; P29353:SHC1; NbExp=2; IntAct=EBI-4309277, EBI-78835; P08047:SP1; NbExp=2; IntAct=EBI-78473, EBI-298336; Q02447:SP3; NbExp=2; IntAct=EBI-78473, EBI-348158; P12931:SRC; NbExp=2; IntAct=EBI-4309277, EBI-621482; Q8N895:ZNF366; NbExp=6; IntAct=EBI-78473, EBI-2813661;
SUBCELLULAR LOCATION: Isoform 1: Nucleus. Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=A minor fraction is associated with the inner membrane.
SUBCELLULAR LOCATION: Isoform 3: Nucleus. Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Single-pass type I membrane protein. Note=Associated with the inner membrane via palmitoylation (Probable). At least a subset exists as a transmembrane protein with a N-terminal extracellular domain.
SUBCELLULAR LOCATION: Nucleus. Golgi apparatus. Cell membrane. Note=Colocalizes with ZDHHC7 and ZDHHC21 in the Golgi apparatus where most probably palmitoylation occurs. Associated with the plasma membrane when palmitoylated.
TISSUE SPECIFICITY: Widely expressed. Isoform 3 is not expressed in the pituitary gland.
DOMAIN: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. The modulating domain, also known as A/B or AF-1 domain has a ligand- independent transactivation function. The C-terminus contains a ligand-dependent transactivation domain, also known as E/F or AF-2 domain which overlaps with the ligand binding domain. AF-1 and AF- 2 activate transcription independently and synergistically and act in a promoter- and cell-specific manner. AF-1 seems to provide the major transactivation function in differentiated cells.
PTM: Phosphorylated by cyclin A/CDK2 and CK1. Phosphorylation probably enhances transcriptional activity. Self-association induces phosphorylation.
PTM: Glycosylated; contains N-acetylglucosamine, probably O- linked.
PTM: Ubiquitinated. Deubiquitinated by OTUB1.
PTM: Dimethylated by PRMT1 at Arg-260. The methylation may favor cytoplasmic localization.
PTM: Palmitoylated (isoform 3). Not biotinylated (isoform 3).
PTM: Palmitoylated by ZDHHC7 and ZDHHC21. Palmitoylation is required for plasma membrane targeting and for rapid intracellular signaling via ERK and AKT kinases and cAMP generation, but not for signaling mediated by the nuclear hormone receptor.
POLYMORPHISM: Genetic variations in ESR1 are correlated with bone mineral density (BMD). Low BMD is a risk factor for osteoporotic fracture. Osteoporosis is characterized by reduced bone mineral density, disrutption of bone microarchitecture, and the alteration of the amount and variety of non-collagenous proteins in bone. Osteoporotic bones are more at risk of fracture.
MISCELLANEOUS: Selective estrogen receptor modulators (SERMs), such as tamoxifen, raloxifene, toremifene, lasofoxifene, clomifene, femarelle and ormeloxifene, have tissue selective agonistic and antagonistic effects on the estrogen receptor (ER). They interfere with the ER association with coactivators or corepressors, mainly involving the AF-2 domain.
SIMILARITY: Belongs to the nuclear hormone receptor family. NR3 subfamily.
SIMILARITY: Contains 1 nuclear receptor DNA-binding domain.
WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/esr1/";
WEB RESOURCE: Name=Wikipedia; Note=Estrogen receptor entry; URL="http://en.wikipedia.org/wiki/Estrogen_receptor";

-  MalaCards Disease Associations
  MalaCards Gene Search: ESR1
Diseases sorted by gene-association score: estrogen resistance* (1689), migraine with or without aura 1* (320), myocardial infarction* (156), breast cancer* (152), brca1 hereditary breast and ovarian cancer syndrome* (133), brca2 hereditary breast and ovarian cancer syndrome* (133), osteoporosis (27), estrogen-receptor negative breast cancer (26), breast ductal carcinoma (26), in situ carcinoma (25), endometrial cancer (25), progesterone-receptor positive breast cancer (24), myoma (22), vulvar syringoma (22), breast disease (22), inflammatory breast carcinoma (21), endometrial disease (20), estrogen-receptor positive breast cancer (19), vaginitis (18), endometrial adenocarcinoma (18), intravenous leiomyomatosis (18), leiomyoma (17), lobular neoplasia (17), female breast cancer (16), ductal carcinoma in situ (16), endometriosis (15), cervical adenocarcinoma (14), breast fibroadenoma (13), osteoporotic fracture (13), juvenile nasopharyngeal angiofibroma (13), pre-malignant neoplasm (13), sebaceous adenoma (12), trigonitis (12), cribriform carcinoma (12), luminal breast carcinoma (12), leiomyomatosis (12), lymphangioleiomyomatosis (12), endometrial stromal sarcoma (11), gynecomastia (11), glassy cell carcinoma of the cervix (10), adenomyosis (10), uterine disease (10), sporadic breast cancer (10), vestibular gland benign neoplasm (10), endometrial clear cell adenocarcinoma (10), bartholin's gland adenoma (10), breast myofibroblastoma (10), breast adenocarcinoma (10), prostatic hypertrophy (9), breast benign neoplasm (9), thoracic benign neoplasm (9), dental fluorosis (9), endocrine gland cancer (9), vulvar benign neoplasm (8), lung leiomyoma (8), progesterone resistance (8), endometrial squamous cell carcinoma (8), uterine fibroid (8), peritoneal mesothelioma (8), angiomyolipoma (8), vulvar vestibulitis syndrome (8), spondylolisthesis (8), fallopian tube carcinoma (8), vulvar leiomyoma (8), glomangiomyoma (8), ovarian cancer, somatic (8), adenosarcoma (8), sweat gland cancer (8), eccrine adenocarcinoma (8), adolescent idiopathic scoliosis (8), endometriosis of ovary (8), mammary paget's disease (8), leydig cell tumor (7), meningioma, familial (7), smooth muscle tumor (7), postmenopausal atrophic vaginitis (7), apocrine adenocarcinoma (7), breast scirrhous carcinoma (7), cardiomyopathy, familial hypertrophic, 9 (7), mucinous adenofibroma (7), trigeminal neuralgia (7), predominantly cortical thymoma (7), oncocytic breast carcinoma (7), gender identity disorder (7), tubular adenocarcinoma (7), reproductive organ benign neoplasm (7), uterine benign neoplasm (7), aromatase deficiency (7), comedo carcinoma (6), bartholin's gland benign neoplasm (6), idiopathic scoliosis (6), syringoma (6), hydrocele (6), vascular malformation (6), endocervical carcinoma (6), adenoid basal cell carcinoma (6), breast papillary carcinoma (6), triple-receptor negative breast cancer (6), female reproductive organ cancer (6), hidradenocarcinoma (5), breast medullary carcinoma (5), breast carcinoma in situ (5), breast metaplastic carcinoma (5), deep angioma (5), estrogen excess (5), postpartum depression (5), spondylosis (5), cervical clear cell adenocarcinoma (5), endometrial mucinous adenocarcinoma (5), colonic disease (5), cervical carcinosarcoma (5), gastric signet ring cell adenocarcinoma (5), endometritis (5), retinitis pigmentosa 20 (5), intramuscular hemangioma (5), breast adenoid cystic carcinoma (5), lipid-rich carcinoma (5), mixed cell type cancer (5), reproductive organ cancer (4), synchronous bilateral breast carcinoma (4), retinitis pigmentosa 47 (4), testicular leydig cell tumor (4), glycogen-rich clear cell breast carcinoma (4), epilepsy, familial temporal lobe, 3 (4), bone resorption disease (4), uterine sarcoma (4), short-rib thoracic dysplasia 5 with or without polydactyly (4), breast giant fibroadenoma (4), pancreatic mucinous cystadenoma (4), cryptorchidism (3), prostate cancer (2), adamantinoma of long bones (2), insulin-like growth factor i (2), bone remodeling disease (1), female reproductive system disease (1), reproductive system disease (1), cell type cancer (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 25.81 RPKM in Cervix - Endocervix
Total median expression: 122.50 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -457.201460-0.313 Picture PostScript Text
3' UTR -10.6087-0.122 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR024736 - Estrogen-typ_rcpt_C
IPR008946 - Nucl_hormone_rcpt_ligand-bd
IPR000536 - Nucl_hrmn_rcpt_lig-bd_core
IPR001292 - Oestr_rcpt
IPR024178 - Oestrogen_rcpt-rel
IPR001723 - Str_hrmn_rcpt
IPR001628 - Znf_hrmn_rcpt
IPR013088 - Znf_NHR/GATA

Pfam Domains:
PF12743 - Oestrogen-type nuclear receptor final C-terminal
PF00104 - Ligand-binding domain of nuclear hormone receptor
PF02159 - Oestrogen receptor
PF00105 - Zinc finger, C4 type (two domains)

Protein Data Bank (PDB) 3-D Structure
MuPIT help

1A52
- X-ray MuPIT

1AKF
- Model

1ERE
- X-ray MuPIT
To conserve bandwidth, only the images from the first 3 structures are shown.
1ERR - X-ray MuPIT 1G50 - X-ray MuPIT 1GWQ - X-ray MuPIT
1GWR - X-ray MuPIT 1HCP - NMR MuPIT 1HCQ - X-ray MuPIT
1L2I - X-ray MuPIT 1PCG - X-ray MuPIT 1QKT - X-ray MuPIT
1QKU - X-ray MuPIT 1R5K - X-ray MuPIT 1SJ0 - X-ray MuPIT
1UOM - X-ray MuPIT 1X7E - X-ray MuPIT 1X7R - X-ray MuPIT
1XP1 - X-ray MuPIT 1XP6 - X-ray MuPIT 1XP9 - X-ray MuPIT
1XPC - X-ray MuPIT 1XQC - X-ray MuPIT 1YIM - X-ray MuPIT
1YIN - X-ray MuPIT 1ZKY - X-ray MuPIT 2AYR - X-ray MuPIT
2B1V - X-ray MuPIT 2B1Z - X-ray MuPIT 2B23 - X-ray MuPIT
2BJ4 - X-ray MuPIT 2FAI - X-ray MuPIT 2G44 - X-ray MuPIT
2G5O - X-ray MuPIT 2I0J - X-ray MuPIT 2IOG - X-ray MuPIT
2IOK - X-ray MuPIT 2JF9 - X-ray MuPIT 2JFA - X-ray MuPIT
2LLO - NMR 2LLQ - NMR 2OCF - X-ray MuPIT
2OUZ - X-ray MuPIT 2P15 - X-ray MuPIT 2POG - X-ray MuPIT
2Q6J - X-ray MuPIT 2Q70 - X-ray MuPIT 2QA6 - X-ray MuPIT
2QA8 - X-ray MuPIT 2QAB - X-ray MuPIT 2QE4 - X-ray MuPIT
2QGT - X-ray MuPIT 2QGW - X-ray MuPIT 2QH6 - X-ray MuPIT
2QR9 - X-ray MuPIT 2QSE - X-ray MuPIT 2QXM - X-ray MuPIT
2QXS - X-ray MuPIT 2QZO - X-ray MuPIT 2R6W - X-ray MuPIT
2R6Y - X-ray MuPIT 2YAT - X-ray MuPIT 2YJA - X-ray MuPIT
3CBM - X-ray MuPIT 3CBO - X-ray MuPIT 3CBP - X-ray MuPIT
3DT3 - X-ray MuPIT 3ERD - X-ray MuPIT 3ERT - X-ray MuPIT
3HLV - X-ray MuPIT 3HM1 - X-ray MuPIT 3L03 - X-ray MuPIT
3OS8 - X-ray MuPIT 3OS9 - X-ray MuPIT 3OSA - X-ray MuPIT
3Q95 - X-ray MuPIT 3Q97 - X-ray 3UU7 - X-ray MuPIT
3UUA - X-ray MuPIT 3UUC - X-ray MuPIT 3UUD - X-ray MuPIT
4AA6 - X-ray MuPIT 4DMA - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P03372
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0001046 core promoter sequence-specific DNA binding
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001093 TFIIB-class transcription factor binding
GO:0001223 transcription coactivator binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0003707 steroid hormone receptor activity
GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
GO:0005496 steroid binding
GO:0005515 protein binding
GO:0008013 beta-catenin binding
GO:0008134 transcription factor binding
GO:0008270 zinc ion binding
GO:0008289 lipid binding
GO:0017025 TBP-class protein binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0030235 nitric-oxide synthase regulator activity
GO:0030284 estrogen receptor activity
GO:0030331 estrogen receptor binding
GO:0034056 estrogen response element binding
GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding
GO:0042802 identical protein binding
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0051117 ATPase binding

Biological Process:
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001547 antral ovarian follicle growth
GO:0002064 epithelial cell development
GO:0006338 chromatin remodeling
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0007165 signal transduction
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0008209 androgen metabolic process
GO:0008584 male gonad development
GO:0010629 negative regulation of gene expression
GO:0010863 positive regulation of phospholipase C activity
GO:0016579 protein deubiquitination
GO:0030111 regulation of Wnt signaling pathway
GO:0030518 intracellular steroid hormone receptor signaling pathway
GO:0030520 intracellular estrogen receptor signaling pathway
GO:0032355 response to estradiol
GO:0033146 regulation of intracellular estrogen receptor signaling pathway
GO:0034121 regulation of toll-like receptor signaling pathway
GO:0042981 regulation of apoptotic process
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043401 steroid hormone mediated signaling pathway
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043627 response to estrogen
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046854 phosphatidylinositol phosphorylation
GO:0048146 positive regulation of fibroblast proliferation
GO:0048863 stem cell differentiation
GO:0050727 regulation of inflammatory response
GO:0051000 positive regulation of nitric-oxide synthase activity
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051897 positive regulation of protein kinase B signaling
GO:0060065 uterus development
GO:0060068 vagina development
GO:0060523 prostate epithelial cord elongation
GO:0060527 prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060687 regulation of branching involved in prostate gland morphogenesis
GO:0060745 mammary gland branching involved in pregnancy
GO:0060749 mammary gland alveolus development
GO:0060750 epithelial cell proliferation involved in mammary gland duct elongation
GO:0071168 protein localization to chromatin
GO:0071391 cellular response to estrogen stimulus
GO:0071392 cellular response to estradiol stimulus
GO:1903799 negative regulation of production of miRNAs involved in gene silencing by miRNA

Cellular Component:
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0032991 macromolecular complex
GO:0035327 transcriptionally active chromatin
GO:0097550 transcriptional preinitiation complex


-  Descriptions from all associated GenBank mRNAs
  AK313644 - Homo sapiens cDNA, FLJ94220.
AK293019 - Homo sapiens cDNA FLJ77952 complete cds, highly similar to Homo sapiens mRNA for oestrogen receptor.
X03635 - Homo sapiens mRNA for oestrogen receptor.
AK304833 - Homo sapiens cDNA FLJ51616 complete cds, highly similar to Estrogen receptor.
AF258449 - Homo sapiens estrogen receptor alpha mRNA, complete cds, alternatively spliced.
AF258450 - Homo sapiens estrogen receptor alpha mRNA, complete cds, alternatively spliced.
AF258451 - Homo sapiens estrogen receptor alpha mRNA, complete cds, alternatively spliced.
M12674 - Human estrogen receptor mRNA, complete cds.
BC128573 - Homo sapiens estrogen receptor 1, mRNA (cDNA clone MGC:157708 IMAGE:40128594), complete cds.
BC128574 - Homo sapiens estrogen receptor 1, mRNA (cDNA clone MGC:157709 IMAGE:40128595), complete cds.
LC120330 - Homo sapiens ESR1 mRNA for human estrogen receptor alpha splice variant, ERalphai67, complete cds.
LC120329 - Homo sapiens ESR1 mRNA for human estrogen receptor alpha splice variant, ERalphaDup5, complete cds.
KJ891123 - Synthetic construct Homo sapiens clone ccsbBroadEn_00517 ESR1 gene, encodes complete protein.
KR711947 - Synthetic construct Homo sapiens clone CCSBHm_00032881 ESR1 (ESR1) mRNA, encodes complete protein.
KR711948 - Synthetic construct Homo sapiens clone CCSBHm_00032882 ESR1 (ESR1) mRNA, encodes complete protein.
AB587448 - Synthetic construct DNA, clone: pF1KB7810, Homo sapiens ESR1 gene for estrogen receptor 1, without stop codon, in Flexi system.
AB307713 - Homo sapiens NR3A1 mRNA for estrogen receptor 1, complete cds.
JF810888 - Homo sapiens estrogen nuclear receptor alpha (ESR1) mRNA, complete cds.
U47678 - Human 80 kDa estrogen receptor mRNA, containing exon 6 and 7 duplication, complete cds.
BX640939 - Homo sapiens mRNA; cDNA DKFZp686N23123 (from clone DKFZp686N23123).
FJ169500 - Homo sapiens estrogen receptor alpha delta 2*,3,4,5,6,7*/834 hypothalamic isoform (ESR1) mRNA, partial cds, alternatively spliced.
GQ411252 - Homo sapiens estrogen receptor alpha delta 2*,3,4,5,6,7 isoform (ESR1) mRNA, partial cds, alternatively spliced.
GQ411256 - Homo sapiens estrogen receptor alpha delta 2*,3,4,5,6,7*/963 isoform (ESR1) mRNA, partial cds, alternatively spliced.
FJ011560 - Homo sapiens pituitary gland estrogen receptor alpha splice variant (ESR1) mRNA, partial cds, alternatively spliced.
EU982838 - Homo sapiens estrogen receptor alpha substantia nigra isoform (ESR1) mRNA, partial cds, alternatively spliced.
FJ147554 - Homo sapiens inferior temporal gyrus estrogen receptor alpha splice variant (ESR1) mRNA, partial cds, alternatively spliced.
GQ411250 - Homo sapiens estrogen receptor alpha delta 3*,4,5,6,7*/819-2 isoform (ESR1) mRNA, partial cds, alternatively spliced.
FJ147552 - Homo sapiens rostral hypothalamus estrogen receptor alpha splice variant (ESR1) mRNA, partial cds, alternatively spliced.
FJ011556 - Homo sapiens caudal hypothalamus estrogen receptor alpha splice variant (ESR1) mRNA, partial cds, alternatively spliced.
FJ011559 - Homo sapiens locus coeruleus estrogen receptor alpha splice variant (ESR1) mRNA, partial cds, alternatively spliced.
FJ712307 - Homo sapiens estrogen receptor alpha delta 3*4*,7 isoform (ESR1) mRNA, partial cds, alternatively spliced.
FJ169503 - Homo sapiens estrogen receptor alpha delta 4*,5,6*/481 hypothalamic isoform (ESR1) mRNA, partial cds, alternatively spliced.
GQ366704 - Homo sapiens estrogen receptor alpha 3*,4,5,6,7*/765 isoform (ESR1) mRNA, partial cds, alternatively spliced.
GQ438790 - Homo sapiens estrogen receptor alpha 3*,4,5,6,7*/822 isoform (ESR1) mRNA, partial cds, alternatively spliced.
FJ169501 - Homo sapiens estrogen receptor alpha delta 3*,4,5,6,7*/775 hypothalamic isoform (ESR1) mRNA, partial cds, alternatively spliced.
GQ411258 - Homo sapiens estrogen receptor alpha delta 4 +49 isoform (ESR1) mRNA, partial cds, alternatively spliced.
GQ389792 - Homo sapiens estrogen receptor alpha 2*,3,4,5,6,7*,8* isoform (ESR1) mRNA, partial cds, alternatively spliced.
FJ147556 - Homo sapiens choroid plexus estrogen receptor alpha splice variant (ESR1) mRNA, partial cds, alternatively spliced.
EU982840 - Homo sapiens estrogen receptor alpha cingulate gyrus isoform (ESR1) mRNA, partial cds, alternatively spliced.
FJ712306 - Homo sapiens estrogen receptor alpha delta 3*4,5,6,7*/840 isoform (ESR1) mRNA, partial cds, alternatively spliced.
FJ716812 - Homo sapiens estrogen receptor alpha delta 4*,5,6,7*/633 isoform (ESR1) mRNA, partial cds, alternatively spliced.
GQ411255 - Homo sapiens estrogen receptor alpha delta 3*,4,5,6,7,8*/984 isoform (ESR1) mRNA, partial cds, alternatively spliced.
FJ011557 - Homo sapiens putamen estrogen receptor alpha splice variant (ESR1) mRNA, partial cds, alternatively spliced.
FJ716813 - Homo sapiens estrogen receptor alpha delta 3*,4,5,6,7*, 8*/912 isoform (ESR1) mRNA, partial cds, alternatively spliced.
FJ716815 - Homo sapiens estrogen receptor alpha delta 4*,5,6,7,8*/885 isoform (ESR1) mRNA, partial cds, alternatively spliced.
GQ411253 - Homo sapiens estrogen receptor alpha delta 4*,5,6,7,8*/901 isoform (ESR1) mRNA, partial cds, alternatively spliced.
GQ411254 - Homo sapiens estrogen receptor alpha delta 3*,4,5,6,7,8*/969 isoform (ESR1) mRNA, partial cds, alternatively spliced.
EU921455 - Homo sapiens estrogen receptor alpha delta 3,4,5,6 isoform (ESR1) mRNA, partial cds, alternatively spliced.
EU982839 - Homo sapiens estrogen receptor alpha superior frontal gyrus isoform (ESR1) mRNA, partial cds, alternatively spliced.
FJ011558 - Homo sapiens pineal gland estrogen receptor alpha splice variant (ESR1) mRNA, partial cds, alternatively spliced.
FJ147553 - Homo sapiens middle hypothalamus estrogen receptor alpha splice variant (ESR1) mRNA, partial cds, alternatively spliced.
FJ147555 - Homo sapiens spinal cord estrogen receptor alpha splice variant (ESR1) mRNA, partial cds, alternatively spliced.
FJ147557 - Homo sapiens rostral hypothalamus estrogen receptor alpha splice variant (ESR1) mRNA, partial cds, alternatively spliced.
FJ147558 - Homo sapiens caudal hypothalamus estrogen receptor alpha splice variant (ESR1) mRNA, partial cds, alternatively spliced.
FJ668387 - Homo sapiens estrogen receptor alpha delta 4,5,7 isoform (ESR1) mRNA, partial cds, alternatively spliced.
FJ712305 - Homo sapiens estrogen receptor alpha delta 3*4,5*,7 isoform (ESR1) mRNA, partial cds, alternatively spliced.
FJ716811 - Homo sapiens estrogen receptor alpha delta 4*,5,6,7,8*/918 isoform (ESR1) mRNA, partial cds, alternatively spliced.
GQ438789 - Homo sapiens estrogen receptor alpha 3*,4,5,6,7,8*/1032 isoform (ESR1) mRNA, partial cds, alternatively spliced.
GQ438793 - Homo sapiens estrogen receptor alpha 3*,4,5,6,7,8*/984 isoform (ESR1) mRNA, partial cds, alternatively spliced.
GQ411257 - Homo sapiens estrogen receptor alpha delta 3*,4,5,6,7,8*/1029 isoform (ESR1) mRNA, partial cds, alternatively spliced.
GQ411251 - Homo sapiens estrogen receptor alpha delta 3*,4,5,6,7*,8*/941 isoform (ESR1) mRNA, partial cds, alternatively spliced.
GQ438792 - Homo sapiens estrogen receptor alpha 3*,4,5,6,7,8*/1068 isoform (ESR1) mRNA, partial cds, alternatively spliced.
X73067 - H. sapiens mRNA for estrogen receptor.
FJ169502 - Homo sapiens estrogen receptor alpha delta 4,7*,8*/581 hypothalamic isoform (ESR1) mRNA, partial cds, alternatively spliced.
FJ716814 - Homo sapiens estrogen receptor alpha delta 6,7 isoform (ESR1) mRNA, partial cds, alternatively spliced.
GQ438791 - Homo sapiens estrogen receptor alpha delta 4*,5,6,7*/654 isoform (ESR1) mRNA, partial cds, alternatively spliced.
AF120105 - Homo sapiens alternatively-spliced estrogen receptor alpha mRNA, partial cds.
S80316 - oestrogen receptor {alternatively spliced, exons 4 and 7} [human, endometrial liver, mRNA Partial Mutant, 144 nt].
AF242866 - Synthetic construct ECFP-estrogen receptor ligand binding domain fusion protein mRNA, complete cds.
AK304600 - Homo sapiens cDNA FLJ51617 complete cds, highly similar to Estrogen receptor.
AF172068 - Homo sapiens fatty acid synthase/estrogen receptor fusion protein (FAS/ER) mRNA, partial cds.
AF172069 - Homo sapiens fatty acid synthase/estrogen receptor fusion protein (FAS/ER) mRNA, partial cds.
Z75126 - H.sapiens mRNA for estrogen receptor (hormone binding region).
X86816 - H.sapiens estrogen receptor cDNA, 5' splice variant.
AB685814 - Homo sapiens ESR1 mRNA for estrogen receptor alpha E1-1-2 variant, partial cds.
AB685815 - Homo sapiens ESR1 mRNA for estrogen receptor alpha E1-E2-1-2 variant, partial cds.
AB685817 - Homo sapiens ESR1 mRNA for estrogen receptor alpha E1-N2-E2-1-2 variant, partial cds.
AB685818 - Homo sapiens ESR1 mRNA for estrogen receptor alpha E1-2 variant, partial cds.
AB685819 - Homo sapiens ESR1 mRNA for estrogen receptor alpha E1-E2-2 variant, partial cds.
AB685820 - Homo sapiens ESR1 mRNA for estrogen receptor alpha E1-N2-E2-2 variant, partial cds.
AB685816 - Homo sapiens ESR1 mRNA for estrogen receptor alpha E1-N1-E2-1 variant, partial cds.
U68068 - Human estrogen receptor mRNA, alternatively spliced transcript H, partial cds.
AK309580 - Homo sapiens cDNA, FLJ99621.
AB588629 - Homo sapiens ESR1 mRNA for estrogen receptor alpha, partial cds, novel splicing F isoform, F-E2-E3-1-2.
AB588630 - Homo sapiens ESR1 mRNA for estrogen receptor alpha, partial cds, novel splicing F isoform, F-E2-E3-2.
EU930361 - Homo sapiens estrogen receptor alpha delta 1*,2,3*/663 choroid plexus isoform (ESR1) mRNA, partial cds, alternatively spliced.
LC120323 - Homo sapiens ESR1 mRNA for human estrogen receptor alpha splice variant, CTERP-1, complete cds.
LC120324 - Homo sapiens ESR1 mRNA for human estrogen receptor alpha splice variant, ERalphai45a, complete cds.
LC120325 - Homo sapiens ESR1 mRNA for human estrogen receptor alpha splice variant, ERalphai45bL, complete cds.
LC120326 - Homo sapiens ESR1 mRNA for human estrogen receptor alpha splice variant, ERalphai45bS, complete cds.
LC120327 - Homo sapiens ESR1 mRNA for human estrogen receptor alpha splice variant, ERalphai45c, complete cds.
LC120328 - Homo sapiens ESR1 mRNA for human estrogen receptor alpha splice variant, ERalphai56, complete cds.
EU447161 - Homo sapiens pineal gland estrogen receptor alpha splice variant mRNA, partial sequence, alternatively spliced.
DQ163909 - Homo sapiens hippocampal estrogen receptor alpha isoform TADDI (ESR1) mRNA, partial cds, alternatively spliced.
X74439 - H.sapiens mRNA for estrogen receptor gene 5'flanking region.
U68067 - Human estrogen receptor mRNA, alternatively spliced transcript E, partial cds.
M69297 - Human estrogen receptor-related protein (variant ER from breast cancer) mRNA, complete cds.
AY750962 - Homo sapiens estrogen receptor alpha mamillary body 1 isoform mRNA, partial cds, alternatively spliced.
EF491789 - Homo sapiens clone ESR1 mRNA, partial sequence; alternatively spliced.
FJ169504 - Homo sapiens estrogen receptor alpha delta 4,5,6,7 isoform (ESR1) mRNA, partial cds, alternatively spliced.
AK311064 - Homo sapiens cDNA, FLJ18106.
CQ753264 - Sequence 3 from Patent WO2004001045.
S79911 - estrogen receptor=ER delta E7 isoform {alternatively spliced isoform} [human, cell line T47D, mRNA Partial, 39 nt].

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_her2Pathway - Role of ERBB2 in Signal Transduction and Oncology
h_EfpPathway - Estrogen-responsive protein Efp controls cell cycle and breast tumors growth
h_pelp1Pathway - Pelp1 Modulation of Estrogen Receptor Activity
h_carm-erPathway - CARM1 and Regulation of the Estrogen Receptor
h_mta3Pathway - Downregulated of MTA-3 in ER-negative Breast Tumors

Reactome (by CSHL, EBI, and GO)

Protein P03372 (Reactome details) participates in the following event(s):

R-HSA-8937369 ATAD2 binds ESR1
R-HSA-9008267 ESR1 binds to TGFA gene promoter
R-HSA-9009541 ESR1 binds to TFF1 gene promoter
R-HSA-376419 Formation of NR-MED1 Coactivator Complex
R-HSA-6783238 OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1
R-HSA-9038029 27-hydroxysterol binds ESR1, ESR2
R-HSA-1254386 ERBB4s80 forms a complex with estrogen receptor ESR1
R-HSA-8931981 RUNX1 binds ESR1
R-HSA-8932070 ESR1 binds the AXIN1 gene
R-HSA-8939904 Activated ESR1 binds the RUNX2 gene promoter
R-HSA-9011952 ESR1:ESTG and KDM4B bind H3K9me3 target gene enhancers
R-HSA-9011983 Overexpressed HIST1H2AC and ESR1:ESTG bind MYC and BCL2 genes
R-HSA-9011997 ESR1:ESTG, JUND:FOSB and Cohesin Complex bind distal enhancer elements in MYC gene promoter
R-HSA-9018325 ESR1:ESTG binds CXXC5 gene
R-HSA-9018499 ESR1:ESTG and EP300 are recruited to TFF3 promoter
R-HSA-9018503 ESR1:ESTG bind the EBAG9 5' region
R-HSA-9023845 ESR1:ESTG binds to proximal and distal regions of the CTSD promoter
R-HSA-9038052 GREB1 binds ESR1:ESTG and co-activators
R-HSA-9008258 NCOA3 binds ESR1:estrogen:TFGA gene
R-HSA-9008270 NCOA1 binds ESR1:estrogen:TGFA gene
R-HSA-9008271 CITED1 and EP300 bind ESR1:estrogen:TGFA gene promoter
R-HSA-9009536 DDX5 binds ESR1:estrogen:TFF1 gene promoter
R-HSA-8939201 ESR dimerizes
R-HSA-8939203 HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex
R-HSA-8939204 ESTG binds the ESR:chaperone complex
R-HSA-8954207 ERBB4s80:ESR1 binds CXCL12 gene promoter
R-HSA-8954208 ERBB4s80:ESR1 binds PGR gene promoter
R-HSA-8932021 RUNX1 and ESR1 bind the GPAM gene enhancer
R-HSA-8932037 RUNX1 and ESR1 bind the KCTD6 gene enhancer
R-HSA-8932084 RUNX1 and ESR1 bind the AXIN1 gene
R-HSA-9009371 Binding of AP1 transcriptional activator complexes to CCND1 promoter
R-HSA-9011984 KDM1A is recruited to MYC and BCL2 genes
R-HSA-9011981 EP300 is recruited to MYC and BCL2 genes
R-HSA-9011985 KDM1A demethylates H3 on MYC and BCL genes in response to estrogen
R-HSA-9011949 KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers
R-HSA-9012315 ESR1:ESTG:P-TEFb recruited to paused RNA polymerase II on MYB gene
R-HSA-9023840 HATs and coactivators are recruited to the CTSD gene
R-HSA-9008285 NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3
R-HSA-9023884 NCOA1 recruits EP300 to TGFA promoter
R-HSA-9009533 TBP and TFIIA bind TATA box on ESR1:estrogen bound TFF1 gene promoter
R-HSA-9012319 p-TEFb phosphorylates serine 2 in RNA polymerase II CTD
R-HSA-9009526 CARM1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene
R-HSA-9023861 PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene
R-HSA-9023860 Histone acetyltransferases are recruited to the TFF1 gene
R-HSA-2400009 PI3K inhibitors block PI3K catalytic activity
R-HSA-2316434 PI3K phosphorylates PIP2 to PIP3
R-HSA-8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
R-HSA-9018519 Estrogen-dependent gene expression
R-HSA-8939211 ESR-mediated signaling
R-HSA-383280 Nuclear Receptor transcription pathway
R-HSA-5689896 Ovarian tumor domain proteases
R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
R-HSA-1251985 Nuclear signaling by ERBB4
R-HSA-8931987 RUNX1 regulates estrogen receptor mediated transcription
R-HSA-8939902 Regulation of RUNX2 expression and activity
R-HSA-9006931 Signaling by Nuclear Receptors
R-HSA-212436 Generic Transcription Pathway
R-HSA-5688426 Deubiquitination
R-HSA-8939256 RUNX1 regulates transcription of genes involved in WNT signaling
R-HSA-1236394 Signaling by ERBB4
R-HSA-8878171 Transcriptional regulation by RUNX1
R-HSA-8878166 Transcriptional regulation by RUNX2
R-HSA-162582 Signal Transduction
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-597592 Post-translational protein modification
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-74160 Gene expression (Transcription)
R-HSA-392499 Metabolism of proteins
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-2219528 PI3K/AKT Signaling in Cancer
R-HSA-9006925 Intracellular signaling by second messengers
R-HSA-199418 Negative regulation of the PI3K/AKT network
R-HSA-5663202 Diseases of signal transduction
R-HSA-1643685 Disease
R-HSA-2400009 PI3K inhibitors block PI3K catalytic activity
R-HSA-2316434 PI3K phosphorylates PIP2 to PIP3
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-2219528 PI3K/AKT Signaling in Cancer
R-HSA-9006925 Intracellular signaling by second messengers
R-HSA-199418 Negative regulation of the PI3K/AKT network
R-HSA-5663202 Diseases of signal transduction
R-HSA-162582 Signal Transduction
R-HSA-1643685 Disease
R-HSA-2400009 PI3K inhibitors block PI3K catalytic activity
R-HSA-2316434 PI3K phosphorylates PIP2 to PIP3
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-2219528 PI3K/AKT Signaling in Cancer
R-HSA-9006925 Intracellular signaling by second messengers
R-HSA-199418 Negative regulation of the PI3K/AKT network
R-HSA-5663202 Diseases of signal transduction
R-HSA-162582 Signal Transduction
R-HSA-1643685 Disease

-  Other Names for This Gene
  Alternate Gene Symbols: AK293019, ESR, ESR1_HUMAN, NR3A1, P03372, Q13511, Q14276, Q5T5H7, Q6MZQ9, Q9NU51, Q9UDZ7, Q9UIS7, uc010kin.1, uc010kin.2, uc010kin.3, uc010kin.4
UCSC ID: uc010kin.4
RefSeq Accession: NM_001122741
Protein: P03372 (aka ESR1_HUMAN)
CCDS: CCDS5234.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.