Description: Homo sapiens FERM domain containing 4A (FRMD4A), transcript variant 1, mRNA. (from RefSeq NM_018027) RefSeq Summary (NM_018027): This gene encodes a FERM domain-containing protein that regulates epithelial cell polarity. It connects ADP ribosylation factor 6 (ARF6) with the Par protein complex, which regulates the remodeling of adherens junctions and linear actin cable formation during epithelial cell polarization. Polymorphisms in this gene are associated with Alzheimer's disease, and also with nicotine dependence. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]. Gencode Transcript: ENST00000357447.7 Gencode Gene: ENSG00000151474.23 Transcript (Including UTRs) Position: hg38 chr10:13,643,706-14,330,924 Size: 687,219 Total Exon Count: 25 Strand: - Coding Region Position: hg38 chr10:13,651,905-14,330,102 Size: 678,198 Coding Exon Count: 23
ID:FRM4A_HUMAN DESCRIPTION: RecName: Full=FERM domain-containing protein 4A; SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton (By similarity). SIMILARITY: Contains 1 FERM domain. CAUTION: It is uncertain whether Met-1 or Met-16 is the initiator. SEQUENCE CAUTION: Sequence=BAA92532.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF11819 - Domain of unknown function (DUF3338) PF09380 - FERM C-terminal PH-like domain PF00373 - FERM central domain PF09379 - FERM N-terminal domain
ModBase Predicted Comparative 3D Structure on Q9P2Q2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.