ID:KLHL9_HUMAN DESCRIPTION: RecName: Full=Kelch-like protein 9; FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis. PATHWAY: Protein modification; protein ubiquitination. SUBUNIT: Component of the BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex, at least composed of CUL3, KLHL9, KLHL13 and RBX1. Interacts with AURKB. SIMILARITY: Contains 1 BACK (BTB/Kelch associated) domain. SIMILARITY: Contains 1 BTB (POZ) domain. SIMILARITY: Contains 6 Kelch repeats. SEQUENCE CAUTION: Sequence=BAA92592.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9P2J3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
KJ899219 - Synthetic construct Homo sapiens clone ccsbBroadEn_08613 KLHL9 gene, encodes complete protein. BC064958 - Homo sapiens cDNA clone IMAGE:6093326, partial cds. AY172949 - Homo sapiens KLHL9 protein mRNA, complete cds. BC052776 - Homo sapiens kelch-like 9 (Drosophila), mRNA (cDNA clone IMAGE:4821138). AK025468 - Homo sapiens cDNA: FLJ21815 fis, clone HEP01095. AK023630 - Homo sapiens cDNA FLJ13568 fis, clone PLACE1008368, weakly similar to RING CANAL PROTEIN. AB037775 - Homo sapiens KIAA1354 mRNA for KIAA1354 protein. AL713669 - Homo sapiens mRNA; cDNA DKFZp761G20121 (from clone DKFZp761G20121). JD053337 - Sequence 34361 from Patent EP1572962. JD451359 - Sequence 432383 from Patent EP1572962. JD233641 - Sequence 214665 from Patent EP1572962. JD188068 - Sequence 169092 from Patent EP1572962. JD050160 - Sequence 31184 from Patent EP1572962. BX538121 - Homo sapiens mRNA; cDNA DKFZp686L0695 (from clone DKFZp686L0695); complete cds. JD436439 - Sequence 417463 from Patent EP1572962. JD345302 - Sequence 326326 from Patent EP1572962. JD350406 - Sequence 331430 from Patent EP1572962. BC039133 - Homo sapiens kelch-like 9 (Drosophila), mRNA (cDNA clone MGC:16975 IMAGE:4339111), complete cds. AK091715 - Homo sapiens cDNA FLJ34396 fis, clone HCHON2000826, highly similar to Kelch-like protein 9. JD083894 - Sequence 64918 from Patent EP1572962. JD110744 - Sequence 91768 from Patent EP1572962. JD052177 - Sequence 33201 from Patent EP1572962. JD239153 - Sequence 220177 from Patent EP1572962. JD353909 - Sequence 334933 from Patent EP1572962. JD377914 - Sequence 358938 from Patent EP1572962. JD110184 - Sequence 91208 from Patent EP1572962. JD040381 - Sequence 21405 from Patent EP1572962. JD083431 - Sequence 64455 from Patent EP1572962. JD240659 - Sequence 221683 from Patent EP1572962. JD429874 - Sequence 410898 from Patent EP1572962. BC113513 - Homo sapiens kelch-like 9 (Drosophila), mRNA (cDNA clone MGC:142073 IMAGE:8322565), complete cds. BC105008 - Homo sapiens kelch-like 9 (Drosophila), mRNA (cDNA clone MGC:132668 IMAGE:8144011), complete cds. JD311127 - Sequence 292151 from Patent EP1572962. JD293619 - Sequence 274643 from Patent EP1572962. JD216951 - Sequence 197975 from Patent EP1572962.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04120 - Ubiquitin mediated proteolysis
Reactome (by CSHL, EBI, and GO)
Protein Q9P2J3 (Reactome details) participates in the following event(s):
R-HSA-8955241 CAND1 binds cytosolic CRL E3 ubiquitin ligases R-HSA-983157 Interaction of E3 with substrate and E2-Ub complex R-HSA-983147 Release of E3 from polyubiquitinated substrate R-HSA-8955289 COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes R-HSA-8956040 COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes R-HSA-983140 Transfer of Ub from E2 to substrate and release of E2 R-HSA-8951664 Neddylation R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation R-HSA-597592 Post-translational protein modification R-HSA-983169 Class I MHC mediated antigen processing & presentation R-HSA-392499 Metabolism of proteins R-HSA-1280218 Adaptive Immune System R-HSA-168256 Immune System
Sequence and Links to Tools and Databases 
