Human Gene TNNT2 (ENST00000367315.6) Description and Page Index
Description: troponin T2, cardiac type (from HGNC TNNT2) RefSeq Summary (NM_001001430): The protein encoded by this gene is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for this gene undergo alternative splicing that results in many tissue-specific isoforms, however, the full-length nature of some of these variants has not yet been determined. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000367315.6 Gencode Gene: ENSG00000118194.20 Transcript (Including UTRs) Position: hg38 chr1:201,359,015-201,373,266 Size: 14,252 Total Exon Count: 14 Strand: - Coding Region Position: hg38 chr1:201,359,210-201,373,254 Size: 14,045 Coding Exon Count: 14
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.