Human Gene PLEKHO1 (ENST00000369126.5) Description and Page Index
  Description: Homo sapiens pleckstrin homology domain containing O1 (PLEKHO1), transcript variant 4, mRNA. (from RefSeq NM_001304724)
Gencode Transcript: ENST00000369126.5
Gencode Gene: ENSG00000023902.14
Transcript (Including UTRs)
   Position: hg38 chr1:150,149,183-150,159,630 Size: 10,448 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg38 chr1:150,158,843-150,159,523 Size: 681 Coding Exon Count: 1 

Page IndexSequence and LinksMalaCardsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:150,149,183-150,159,630)mRNA (may differ from genome)Protein (226 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
LynxMGIOMIMPubMedStanford SOURCEUniProtKB
Wikipedia

-  MalaCards Disease Associations
  MalaCards Gene Search: PLEKHO1
Diseases sorted by gene-association score: colonic benign neoplasm (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 94.46 RPKM in Colon - Sigmoid
Total median expression: 1013.86 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -361.901021-0.354 Picture PostScript Text
3' UTR -22.10107-0.207 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  ModBase Predicted Comparative 3D Structure on Q5T4P9
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Descriptions from all associated GenBank mRNAs
  BC023533 - Homo sapiens pleckstrin homology domain containing, family O member 1, mRNA (cDNA clone IMAGE:4122584), partial cds.
AK302255 - Homo sapiens cDNA FLJ61462 complete cds, highly similar to Homo sapiens CK2 interacting protein 1; HQ0024c protein (CKIP-1), mRNA.
AF192912 - Homo sapiens OC120 (OC120) mRNA, complete cds.
AF291105 - Homo sapiens c-Jun binding protein JBP mRNA, complete cds.
AF217956 - Homo sapiens CK2-interacting protein-1 mRNA, complete cds.
AF168676 - Homo sapiens TNF intracellular domain-interacting protein mRNA, complete cds.
BC010149 - Homo sapiens pleckstrin homology domain containing, family O member 1, mRNA (cDNA clone MGC:19483 IMAGE:4330014), complete cds.
CU679641 - Synthetic construct Homo sapiens gateway clone IMAGE:100018237 5' read PLEKHO1 mRNA.
AB464030 - Synthetic construct DNA, clone: pF1KB8228, Homo sapiens PLEKHO1 gene for pleckstrin homology domain containing, family O member 1, without stop codon, in Flexi system.
DQ893381 - Synthetic construct clone IMAGE:100006011; FLH199453.01X; RZPDo839A0982D pleckstrin homology domain containing, family O member 1 (PLEKHO1) gene, encodes complete protein.
DQ896780 - Synthetic construct Homo sapiens clone IMAGE:100011240; FLH199359.01L; RZPDo839A0981D pleckstrin homology domain containing, family O member 1 (PLEKHO1) gene, encodes complete protein.
KJ893844 - Synthetic construct Homo sapiens clone ccsbBroadEn_03238 PLEKHO1 gene, encodes complete protein.
AK222921 - Homo sapiens mRNA for CK2 interacting protein 1; HQ0024c protein variant, clone: HRC06153.
AF073836 - Homo sapiens HQ0024c mRNA, complete cds.
LF211913 - JP 2014500723-A/19416: Polycomb-Associated Non-Coding RNAs.
MA447490 - JP 2018138019-A/19416: Polycomb-Associated Non-Coding RNAs.
AK125609 - Homo sapiens cDNA FLJ43621 fis, clone SPLEN2023160, highly similar to Homo sapiens TNF intracellular domain-interacting protein.
AK025937 - Homo sapiens cDNA: FLJ22284 fis, clone HRC03921, highly similar to AF073836 Homo sapiens HQ0024c mRNA.
AK021865 - Homo sapiens cDNA FLJ11803 fis, clone HEMBA1006268, highly similar to Homo sapiens HQ0024c mRNA.
AM392528 - Synthetic construct Homo sapiens clone IMAGE:100002715 for hypothetical protein (PLEKHO1 gene).
AM392600 - Synthetic construct Homo sapiens clone IMAGE:100002716 for hypothetical protein (PLEKHO1 gene).
AM393378 - Synthetic construct Homo sapiens clone IMAGE:100002963 for hypothetical protein (PLEKHO1 gene).
JD220636 - Sequence 201660 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: hCG_39382, NM_001304724, Q5T4P9, Q5T4P9_HUMAN, RP11-458I7.3-002, uc001ets.1, uc001ets.2, uc001ets.3, uc001ets.4
UCSC ID: uc001ets.4
RefSeq Accession: NM_001304724
Protein: Q5T4P9 CCDS: CCDS76210.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.