Human Gene PHPT1 (ENST00000371661.5) Description and Page Index
Description: Homo sapiens phosphohistidine phosphatase 1 (PHPT1), transcript variant 5, mRNA. (from RefSeq NM_001287343) RefSeq Summary (NM_001135861): This gene encodes an enzyme that catalyzes the reversible dephosphorylation of histidine residues in proteins. It may be involved in the dephosphorylation of G-beta and ATP citrate lyase and in negatively regulating CD4 T lymphocytes by dephosphorylation and inhibition of KCa3.1 channels. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BM975420.1, CD242442.1 [ECO:0000332] ##Evidence-Data-END## Gencode Transcript: ENST00000371661.5 Gencode Gene: ENSG00000054148.17 Transcript (Including UTRs) Position: hg38 chr9:136,848,724-136,851,022 Size: 2,299 Total Exon Count: 5 Strand: + Coding Region Position: hg38 chr9:136,849,431-136,850,789 Size: 1,359 Coding Exon Count: 4
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NRX4
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.