Human Gene PHPT1 (ENST00000371661.5) Description and Page Index
  Description: Homo sapiens phosphohistidine phosphatase 1 (PHPT1), transcript variant 5, mRNA. (from RefSeq NM_001287343)
RefSeq Summary (NM_001135861): This gene encodes an enzyme that catalyzes the reversible dephosphorylation of histidine residues in proteins. It may be involved in the dephosphorylation of G-beta and ATP citrate lyase and in negatively regulating CD4 T lymphocytes by dephosphorylation and inhibition of KCa3.1 channels. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BM975420.1, CD242442.1 [ECO:0000332] ##Evidence-Data-END##
Gencode Transcript: ENST00000371661.5
Gencode Gene: ENSG00000054148.17
Transcript (Including UTRs)
   Position: hg38 chr9:136,848,724-136,851,022 Size: 2,299 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg38 chr9:136,849,431-136,850,789 Size: 1,359 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathways
Other NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr9:136,848,724-136,851,022)mRNA (may differ from genome)Protein (124 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
LynxMGIneXtProtOMIMPubMedStanford SOURCE

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=14 kDa phosphohistidine phosphatase; EC=3.1.3.-; AltName: Full=Phosphohistidine phosphatase 1; AltName: Full=Protein janus-A homolog;
FUNCTION: Exhibits phosphohistidine phosphatase activity.
SUBUNIT: Monomer.
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
TISSUE SPECIFICITY: Expressed abundantly in heart and skeletal muscle.
SIMILARITY: Belongs to the janus family.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 51.41 RPKM in Brain - Cerebellum
Total median expression: 1211.92 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -163.70377-0.434 Picture PostScript Text
3' UTR -84.80233-0.364 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007702 - Ocnus

Pfam Domains:
PF05005 - Janus/Ocnus family (Ocnus)

Protein Data Bank (PDB) 3-D Structure
MuPIT help


- X-ray MuPIT

- X-ray MuPIT
To conserve bandwidth, only the images from the first 3 structures are shown.

ModBase Predicted Comparative 3D Structure on Q9NRX4
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004721 phosphoprotein phosphatase activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0019855 calcium channel inhibitor activity
GO:0044325 ion channel binding
GO:0101006 protein histidine phosphatase activity

Biological Process:
GO:0006470 protein dephosphorylation
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0035971 peptidyl-histidine dephosphorylation
GO:0050860 negative regulation of T cell receptor signaling pathway
GO:0051350 negative regulation of lyase activity
GO:2000147 positive regulation of cell motility
GO:2000249 regulation of actin cytoskeleton reorganization
GO:2000984 negative regulation of ATP citrate synthase activity

Cellular Component:
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0070062 extracellular exosome

-  Descriptions from all associated GenBank mRNAs
  LF205589 - JP 2014500723-A/13092: Polycomb-Associated Non-Coding RNAs.
MA441166 - JP 2018138019-A/13092: Polycomb-Associated Non-Coding RNAs.
AF131857 - Homo sapiens clone 24870 mRNA sequence.
AF285119 - Homo sapiens CGI-202 mRNA, complete cds.
EU794646 - Homo sapiens epididymis secretory sperm binding protein Li 132P (HEL-S-132P) mRNA, complete cds.
JD140889 - Sequence 121913 from Patent EP1572962.
AL136644 - Homo sapiens mRNA; cDNA DKFZp564M173 (from clone DKFZp564M173).
BC024648 - Homo sapiens phosphohistidine phosphatase 1, mRNA (cDNA clone MGC:24855 IMAGE:4934238), complete cds.
AF161490 - Homo sapiens HSPC141 mRNA, complete cds.
AF164795 - Homo sapiens sex-regulated protein janus-a mRNA, complete cds.
AB528207 - Synthetic construct DNA, clone: pF1KE0145, Homo sapiens PHP14 gene for phosphohistidine phosphatase 1, without stop codon, in Flexi system.
AM393672 - Synthetic construct Homo sapiens clone IMAGE:100002097 for hypothetical protein (PHPT1 gene).
KJ898712 - Synthetic construct Homo sapiens clone ccsbBroadEn_08106 PHPT1 gene, encodes complete protein.
AF393504 - Homo sapiens phosphohistidine phosphatase mRNA, complete cds.
CR533481 - Homo sapiens full open reading frame cDNA clone RZPDo834B0917D for gene PHP14, phosphohistidine phosphatase; complete cds, incl. stopcodon.
LF346346 - JP 2014500723-A/153849: Polycomb-Associated Non-Coding RNAs.
MA581923 - JP 2018138019-A/153849: Polycomb-Associated Non-Coding RNAs.
LF346345 - JP 2014500723-A/153848: Polycomb-Associated Non-Coding RNAs.
MA581922 - JP 2018138019-A/153848: Polycomb-Associated Non-Coding RNAs.
JD144172 - Sequence 125196 from Patent EP1572962.
JD538423 - Sequence 519447 from Patent EP1572962.
JD196377 - Sequence 177401 from Patent EP1572962.
JD525215 - Sequence 506239 from Patent EP1572962.
JD176853 - Sequence 157877 from Patent EP1572962.
JD274957 - Sequence 255981 from Patent EP1572962.
JD326392 - Sequence 307416 from Patent EP1572962.
JD287690 - Sequence 268714 from Patent EP1572962.
JD261816 - Sequence 242840 from Patent EP1572962.
JD431507 - Sequence 412531 from Patent EP1572962.
AL137659 - Homo sapiens mRNA; cDNA DKFZp434I1716 (from clone DKFZp434I1716).
JD058334 - Sequence 39358 from Patent EP1572962.
JD403220 - Sequence 384244 from Patent EP1572962.
JD540172 - Sequence 521196 from Patent EP1572962.
JD172133 - Sequence 153157 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa00051 - Fructose and mannose metabolism
hsa00730 - Thiamine metabolism
hsa00740 - Riboflavin metabolism
hsa01100 - Metabolic pathways

-  Other Names for This Gene
  Alternate Gene Symbols: B1AMX0, B1AMX1, CGI-202, HSPC141, NM_001287343, PHP14, PHP14_HUMAN, Q9H0Y3, Q9NRX4, uc064xew.1
UCSC ID: uc064xew.1
RefSeq Accession: NM_001135861
Protein: Q9NRX4 (aka PHP14_HUMAN or PHP1_HUMAN)
CCDS: CCDS48060.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.