Human Gene LYPLA2 (ENST00000374505.6) Description and Page Index
  Description: lysophospholipase II (from HGNC LYPLA2)
RefSeq Summary (NM_007260): Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. There are alternatively spliced transcript variants described for this gene but the full length nature is not known yet. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.871189.1, SRR3476690.314866.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000374514.8/ ENSP00000363638.3 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END##
Gencode Transcript: ENST00000374505.6
Gencode Gene: ENSG00000011009.11
Transcript (Including UTRs)
   Position: hg38 chr1:23,791,187-23,794,745 Size: 3,559 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg38 chr1:23,792,683-23,794,342 Size: 1,660 Coding Exon Count: 6 

Page IndexSequence and LinksCTDRNA-Seq ExpressionMicroarray ExpressionRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther Names
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr1:23,791,187-23,794,745)mRNA (may differ from genome)Protein (137 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
MGImyGene2PubMedStanford SOURCEUniProtKB

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 42.37 RPKM in Kidney - Cortex
Total median expression: 1039.21 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -28.5090-0.317 Picture PostScript Text
3' UTR -154.60403-0.384 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR003140 - PLipase/COase/thioEstase

Pfam Domains:
PF02230 - Phospholipase/Carboxylesterase

ModBase Predicted Comparative 3D Structure on Q5QPN9
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0016787 hydrolase activity

-  Descriptions from all associated GenBank mRNAs
  AF098668 - Homo sapiens acyl-protein thioesterase mRNA, complete cds.
HM005316 - Homo sapiens clone HTL-T-3 testicular tissue protein Li 3 mRNA, complete cds.
BC017034 - Homo sapiens lysophospholipase II, mRNA (cDNA clone MGC:9106 IMAGE:3845764), complete cds.
JD493963 - Sequence 474987 from Patent EP1572962.
BC017193 - Homo sapiens lysophospholipase II, mRNA (cDNA clone MGC:1904 IMAGE:3138786), complete cds.
AF090423 - Homo sapiens lysophospholipase LPL-I mRNA, complete cds.
JD191057 - Sequence 172081 from Patent EP1572962.
DQ896824 - Synthetic construct Homo sapiens clone IMAGE:100011284; FLH177210.01L; RZPDo839E08123D lysophospholipase II (LYPLA2) gene, encodes complete protein.
EU176281 - Synthetic construct Homo sapiens clone IMAGE:100006389; FLH177216.01X; RZPDo839F12250D lysophospholipase II (LYPLA2) gene, encodes complete protein.
AK024724 - Homo sapiens cDNA: FLJ21071 fis, clone CAS01789, highly similar to AF098668 Homo sapiens acyl-protein thioesterase mRNA.
JD258525 - Sequence 239549 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa00564 - Glycerophospholipid metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: AF098668, Q5QPN9, Q5QPN9_HUMAN, RP5-886K2.5-004, uc057dgs.1
UCSC ID: uc057dgs.1
RefSeq Accession: NM_007260
Protein: Q5QPN9

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.