Human Gene ACOT7 (ENST00000377842.7) from GENCODE V44
Description: Homo sapiens acyl-CoA thioesterase 7 (ACOT7), transcript variant hBACHd, mRNA. (from RefSeq NM_181866) RefSeq Summary (NM_181866): This gene encodes a member of the acyl coenzyme family. The encoded protein hydrolyzes the CoA thioester of palmitoyl-CoA and other long-chain fatty acids. Decreased expression of this gene may be associated with mesial temporal lobe epilepsy. Alternatively spliced transcript variants encoding distinct isoforms with different subcellular locations have been characterized. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000377842.7 Gencode Gene: ENSG00000097021.21 Transcript (Including UTRs) Position: hg38 chr1:6,264,273-6,359,344 Size: 95,072 Total Exon Count: 9 Strand: - Coding Region Position: hg38 chr1:6,264,597-6,358,845 Size: 94,249 Coding Exon Count: 9
ID:BACH_HUMAN DESCRIPTION: RecName: Full=Cytosolic acyl coenzyme A thioester hydrolase; EC=3.1.2.2; AltName: Full=Acyl-CoA thioesterase 7; AltName: Full=Brain acyl-CoA hydrolase; Short=BACH; AltName: Full=CTE-IIa; Short=CTE-II; AltName: Full=Long chain acyl-CoA thioester hydrolase; FUNCTION: Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. May play an important physiological function in brain. May play a regulatory role by modulating the cellular levels of fatty acyl- CoA ligands for certain transcription factors as well as the substrates for fatty acid metabolizing enzymes, contributing to lipid homeostasis. Has broad specificity, active towards fatty acyl-CoAs with chain-lengths of C8-C18. Has a maximal activity toward palmitoyl-CoA. CATALYTIC ACTIVITY: Palmitoyl-CoA + H(2)O = CoA + palmitate. SUBUNIT: Homohexamer (By similarity). SUBCELLULAR LOCATION: Isoform 4: Cytoplasm. SUBCELLULAR LOCATION: Isoform 6: Cytoplasm. SUBCELLULAR LOCATION: Isoform 1: Mitochondrion. SUBCELLULAR LOCATION: Isoform 5: Mitochondrion. TISSUE SPECIFICITY: Isoform 4 is expressed exclusively in brain. DOMAIN: Both hydrolase domains are required for efficient activity (By similarity). SIMILARITY: Contains 2 acyl coenzyme A hydrolase domains. SEQUENCE CAUTION: Sequence=AAB61211.1; Type=Frameshift; Positions=371; Sequence=AAH17365.2; Type=Erroneous initiation; Sequence=CAI19435.1; Type=Erroneous initiation; Sequence=CAI19774.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O00154
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006637 acyl-CoA metabolic process GO:0015937 coenzyme A biosynthetic process GO:0036114 medium-chain fatty-acyl-CoA catabolic process GO:0036116 long-chain fatty-acyl-CoA catabolic process GO:0051792 medium-chain fatty acid biosynthetic process GO:1900535 palmitic acid biosynthetic process
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