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Human Gene MCUR1 (ENST00000379170.9) from GENCODE V49
  Description: mitochondrial calcium uniporter regulator 1 (from RefSeq NM_001031713.4)
Gencode Transcript: ENST00000379170.9
Gencode Gene: ENSG00000050393.13
Transcript (Including UTRs)
   Position: hg38 chr6:13,786,557-13,814,557 Size: 28,001 Total Exon Count: 9 Strand: -
Coding Region
   Position: hg38 chr6:13,790,809-13,814,429 Size: 23,621 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2025-09-17 13:57:07

-  Comments and Description Text from UniProtKB
  ID: CC90A_HUMAN
DESCRIPTION: RecName: Full=Coiled-coil domain-containing protein 90A, mitochondrial; Flags: Precursor;
SUBCELLULAR LOCATION: Mitochondrion. Membrane; Single-pass membrane protein (Potential).
SIMILARITY: Belongs to the CCDC90 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 9.06 RPKM in Skin - Not Sun Exposed (Suprapubic)
Total median expression: 244.64 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
 
Expression ratio colors:

GNF Expression Atlas 2 Data from U133A and GNF1H Chips

      
      
      
     
    
     
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -56.40128-0.441 Picture PostScript Text
3' UTR -1406.004252-0.331 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR024461 - DUF1640

Pfam Domains:
PF07798 - Protein of unknown function (DUF1640)

ModBase Predicted Comparative 3D Structure on Q96AQ8
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsembl   
Protein SequenceProtein SequenceProtein Sequence   
AlignmentAlignmentAlignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Biological Process:
GO:0006811 ion transport
GO:0006816 calcium ion transport
GO:0006851 mitochondrial calcium ion transport
GO:0036444 mitochondrial calcium uptake
GO:0051561 positive regulation of mitochondrial calcium ion concentration
GO:0070509 calcium ion import

Cellular Component:
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031305 integral component of mitochondrial inner membrane


-  Descriptions from all associated GenBank mRNAs
  AK123750 - Homo sapiens cDNA FLJ41756 fis, clone IMR322002035.
BX640678 - Homo sapiens mRNA; cDNA DKFZp686A1197 (from clone DKFZp686A1197).
AK026843 - Homo sapiens cDNA: FLJ23190 fis, clone LNG12190.
JD424422 - Sequence 405446 from Patent EP1572962.
JD217311 - Sequence 198335 from Patent EP1572962.
JD343781 - Sequence 324805 from Patent EP1572962.
JD546856 - Sequence 527880 from Patent EP1572962.
JD264739 - Sequence 245763 from Patent EP1572962.
JD125664 - Sequence 106688 from Patent EP1572962.
BC016850 - Homo sapiens coiled-coil domain containing 90A, mRNA (cDNA clone MGC:16830 IMAGE:3886144), complete cds.
GQ891536 - Homo sapiens clone HEL-S-257 epididymis secretory sperm binding protein mRNA, complete cds.
AK024611 - Homo sapiens cDNA: FLJ20958 fis, clone ADSE02059.
BC008234 - Homo sapiens coiled-coil domain containing 90A, mRNA (cDNA clone IMAGE:3856331), partial cds.
KJ894516 - Synthetic construct Homo sapiens clone ccsbBroadEn_03910 CCDC90A gene, encodes complete protein.
JD431277 - Sequence 412301 from Patent EP1572962.
JD159404 - Sequence 140428 from Patent EP1572962.
JD266606 - Sequence 247630 from Patent EP1572962.
JD037803 - Sequence 18827 from Patent EP1572962.
JD168744 - Sequence 149768 from Patent EP1572962.
JD553814 - Sequence 534838 from Patent EP1572962.
JD486994 - Sequence 468018 from Patent EP1572962.
JD394474 - Sequence 375498 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: C6orf79 , CCDC90A , ENST00000379170.1, ENST00000379170.2, ENST00000379170.3, ENST00000379170.4, ENST00000379170.5, ENST00000379170.6, ENST00000379170.7, ENST00000379170.8, MCUR1 , MCUR1_HUMAN, NM_001031713, Q96AQ8, Q96JS7, Q9H7F8, uc003nbc.1, uc003nbc.2, uc003nbc.3, uc003nbc.4
UCSC ID: ENST00000379170.9
RefSeq Accession: NM_001031713.4
Protein: Q96AQ8 (aka CC90A_HUMAN)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.