Human Gene MYH10 (ENST00000379980.8) from GENCODE V38
  Description: Homo sapiens myosin heavy chain 10 (MYH10), transcript variant 4, mRNA. (from RefSeq NM_001375266)
RefSeq Summary (NM_001256095): This gene encodes a member of the myosin superfamily. The protein represents a conventional non-muscle myosin; it should not be confused with the unconventional myosin-10 (MYO10). Myosins are actin-dependent motor proteins with diverse functions including regulation of cytokinesis, cell motility, and cell polarity. Mutations in this gene have been associated with May-Hegglin anomaly and developmental defects in brain and heart. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011].
Gencode Transcript: ENST00000379980.8
Gencode Gene: ENSG00000133026.13
Transcript (Including UTRs)
   Position: hg38 chr17:8,474,207-8,630,761 Size: 156,555 Total Exon Count: 42 Strand: -
Coding Region
   Position: hg38 chr17:8,475,804-8,623,246 Size: 147,443 Coding Exon Count: 41 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated at UCSC: 2021-09-27 09:51:20

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:8,474,207-8,630,761)mRNA (may differ from genome)Protein (1985 aa)
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UniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: MYH10_HUMAN
DESCRIPTION: RecName: Full=Myosin-10; AltName: Full=Cellular myosin heavy chain, type B; AltName: Full=Myosin heavy chain 10; AltName: Full=Myosin heavy chain, non-muscle IIb; AltName: Full=Non-muscle myosin heavy chain B; Short=NMMHC-B; AltName: Full=Non-muscle myosin heavy chain IIb; Short=NMMHC II-b; Short=NMMHC-IIB;
FUNCTION: Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2.
SUBUNIT: Myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). Interacts with PLEKHG6. Interacts with ECM29. Interacts with KIF26B (By similarity). Interacts with LARP6.
TISSUE SPECIFICITY: Isoform 1 is expressed in cerebellum and spinal chord. Isoform 2 is expressed in cerebrum and retina. Isoform 3 is expressed in the cerebrum and to a much lower extent in cerebellum.
DOMAIN: The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
PTM: Phosphorylated by ABL2 (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR.
SIMILARITY: Contains 1 IQ domain.
SIMILARITY: Contains 1 myosin head-like domain.
CAUTION: Represents a conventional non-muscle myosin. This protein should not be confused with the unconventional myosin-10 (MYO10).

-  MalaCards Disease Associations
  MalaCards Gene Search: MYH10
Diseases sorted by gene-association score: may-hegglin anomaly (13), lymphangioleiomyomatosis (6), infantile myofibromatosis (5), intellectual disability (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 298.04 RPKM in Artery - Aorta
Total median expression: 1020.64 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -52.70139-0.379 Picture PostScript Text
3' UTR -454.801597-0.285 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000048 - IQ_motif_EF-hand-BS
IPR001609 - Myosin_head_motor_dom
IPR004009 - Myosin_N
IPR008989 - Myosin_S1_N
IPR002928 - Myosin_tail

Pfam Domains:
PF00612 - IQ calmodulin-binding motif
PF00063 - Myosin head (motor domain)
PF02736 - Myosin N-terminal SH3-like domain
PF01576 - Myosin tail

ModBase Predicted Comparative 3D Structure on P35580
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologGenome BrowserGenome BrowserGenome Browser
Gene Details    Gene Details
Gene Sorter    Gene Sorter
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Protein SequenceProtein Sequence Protein SequenceProtein SequenceProtein Sequence
AlignmentAlignment AlignmentAlignmentAlignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000146 microfilament motor activity
GO:0000166 nucleotide binding
GO:0003774 motor activity
GO:0003777 microtubule motor activity
GO:0003779 actin binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0008017 microtubule binding
GO:0016887 ATPase activity
GO:0030898 actin-dependent ATPase activity
GO:0035613 RNA stem-loop binding
GO:0043531 ADP binding
GO:0048027 mRNA 5'-UTR binding
GO:0051015 actin filament binding

Biological Process:
GO:0000281 mitotic cytokinesis
GO:0001701 in utero embryonic development
GO:0001764 neuron migration
GO:0001778 plasma membrane repair
GO:0003279 cardiac septum development
GO:0006887 exocytosis
GO:0006930 substrate-dependent cell migration, cell extension
GO:0007018 microtubule-based movement
GO:0007097 nuclear migration
GO:0007155 cell adhesion
GO:0007409 axonogenesis
GO:0007411 axon guidance
GO:0007420 brain development
GO:0007507 heart development
GO:0007512 adult heart development
GO:0008283 cell proliferation
GO:0008360 regulation of cell shape
GO:0021592 fourth ventricle development
GO:0021670 lateral ventricle development
GO:0021678 third ventricle development
GO:0021680 cerebellar Purkinje cell layer development
GO:0030036 actin cytoskeleton organization
GO:0030048 actin filament-based movement
GO:0030239 myofibril assembly
GO:0031032 actomyosin structure organization
GO:0031175 neuron projection development
GO:0035904 aorta development
GO:0050714 positive regulation of protein secretion
GO:0050885 neuromuscular process controlling balance
GO:0055003 cardiac myofibril assembly
GO:0055015 ventricular cardiac muscle cell development
GO:0060041 retina development in camera-type eye
GO:0060976 coronary vasculature development
GO:0098885 modification of postsynaptic actin cytoskeleton

Cellular Component:
GO:0001725 stress fiber
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005819 spindle
GO:0005829 cytosol
GO:0005844 polysome
GO:0005886 plasma membrane
GO:0005903 brush border
GO:0005938 cell cortex
GO:0016459 myosin complex
GO:0016460 myosin II complex
GO:0030027 lamellipodium
GO:0030424 axon
GO:0030426 growth cone
GO:0030496 midbody
GO:0031594 neuromuscular junction
GO:0032154 cleavage furrow
GO:0042641 actomyosin
GO:0042995 cell projection
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043197 dendritic spine
GO:0070062 extracellular exosome
GO:0097513 myosin II filament


-  Descriptions from all associated GenBank mRNAs
  AB210026 - Homo sapiens mRNA for MYH10 variant protein, clone: hf00991.
M69181 - Human nonmuscle myosin heavy chain-B (MYH10) mRNA, partial cds.
BC144668 - Homo sapiens myosin, heavy chain 10, non-muscle, mRNA (cDNA clone MGC:178216 IMAGE:9053199), complete cds.
BC150634 - Homo sapiens myosin, heavy chain 10, non-muscle, mRNA (cDNA clone MGC:183544 IMAGE:9057004), complete cds.
BC117690 - Homo sapiens myosin, heavy chain 10, non-muscle, mRNA (cDNA clone MGC:134913 IMAGE:40072059), complete cds.
BC117691 - Homo sapiens myosin, heavy chain 10, non-muscle, mRNA (cDNA clone MGC:134914 IMAGE:40072061), complete cds.
AB463132 - Synthetic construct DNA, clone: pF1KB0047, Homo sapiens MYH10 gene for myosin, heavy chain 10, non-muscle, without stop codon, in Flexi system.
BC008968 - Homo sapiens myosin, heavy chain 10, non-muscle, mRNA (cDNA clone IMAGE:3028454), partial cds.
BC000280 - Homo sapiens myosin, heavy chain 10, non-muscle, mRNA (cDNA clone IMAGE:3357927), partial cds.
AK026977 - Homo sapiens cDNA: FLJ23324 fis, clone HEP12482, highly similar to HUMMYOHCB Human nonmuscle myosin heavy chain-B (MYH10) mRNA.
JD407912 - Sequence 388936 from Patent EP1572962.
JD553081 - Sequence 534105 from Patent EP1572962.
JD283169 - Sequence 264193 from Patent EP1572962.
JD050133 - Sequence 31157 from Patent EP1572962.
JD245956 - Sequence 226980 from Patent EP1572962.
JD245955 - Sequence 226979 from Patent EP1572962.
JD555201 - Sequence 536225 from Patent EP1572962.
JD300132 - Sequence 281156 from Patent EP1572962.
JD379103 - Sequence 360127 from Patent EP1572962.
JD052682 - Sequence 33706 from Patent EP1572962.
JD250018 - Sequence 231042 from Patent EP1572962.
JD477755 - Sequence 458779 from Patent EP1572962.
JD185006 - Sequence 166030 from Patent EP1572962.
JD077688 - Sequence 58712 from Patent EP1572962.
AF086505 - Homo sapiens full length insert cDNA clone ZE02D01.
JD308598 - Sequence 289622 from Patent EP1572962.
JD327360 - Sequence 308384 from Patent EP1572962.
JD439073 - Sequence 420097 from Patent EP1572962.
JD083492 - Sequence 64516 from Patent EP1572962.
JD153144 - Sequence 134168 from Patent EP1572962.
JD523593 - Sequence 504617 from Patent EP1572962.
S67247 - smooth muscle myosin heavy chain isoform SMemb [human, umbilical cord, fetal aorta, mRNA Partial, 971 nt].
JD111274 - Sequence 92298 from Patent EP1572962.
JD469867 - Sequence 450891 from Patent EP1572962.
JD055332 - Sequence 36356 from Patent EP1572962.
JD552040 - Sequence 533064 from Patent EP1572962.
JD292729 - Sequence 273753 from Patent EP1572962.
JD334631 - Sequence 315655 from Patent EP1572962.
JD233947 - Sequence 214971 from Patent EP1572962.
JD491134 - Sequence 472158 from Patent EP1572962.
DQ580154 - Homo sapiens piRNA piR-48266, complete sequence.
DQ925667 - Homo sapiens clone 1-3 nonmuscle myosin heavy chain 10 (MYH10) mRNA, partial cds, alternatively spliced.
JD315557 - Sequence 296581 from Patent EP1572962.
JD184281 - Sequence 165305 from Patent EP1572962.
JD080376 - Sequence 61400 from Patent EP1572962.
U15618 - Human nonmuscle myosin heavy chain-B mRNA, partial cds.
JD043396 - Sequence 24420 from Patent EP1572962.
JD469455 - Sequence 450479 from Patent EP1572962.
JD042448 - Sequence 23472 from Patent EP1572962.
AB621820 - Homo sapiens MYH10 mRNA for myosin-10, partial cds, clone: HP08316-RBdS007C12.
JD332769 - Sequence 313793 from Patent EP1572962.
U34304 - Human nonmuscle myosin heavy chain IIB mRNA, partial cds.
JD348620 - Sequence 329644 from Patent EP1572962.
JD197357 - Sequence 178381 from Patent EP1572962.
JD111043 - Sequence 92067 from Patent EP1572962.
JD103585 - Sequence 84609 from Patent EP1572962.
JD140900 - Sequence 121924 from Patent EP1572962.
JD443237 - Sequence 424261 from Patent EP1572962.
JD044426 - Sequence 25450 from Patent EP1572962.
JD038909 - Sequence 19933 from Patent EP1572962.
JD502784 - Sequence 483808 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04530 - Tight junction
hsa04810 - Regulation of actin cytoskeleton
hsa05416 - Viral myocarditis

Reactome (by CSHL, EBI, and GO)

Protein P35580 (Reactome details) participates in the following event(s):

R-HSA-419197 Myosin regulatory light chain phosphorylation by ROCK
R-HSA-3928616 Activated ROCK phosphorylates MRLCs
R-HSA-5668932 PAK2 phosphorylates myosin regulatory light chain (MRLC)
R-HSA-5668978 MYLK (MLCK) phosphorylates MRLCs of the non-muscle myosin II complex
R-HSA-5671919 Activated CIT phosphorylates MRLCs
R-HSA-419232 Myosin phosphatase dephosphorylates myosin regulatory light chain
R-HSA-416572 Sema4D induced cell migration and growth-cone collapse
R-HSA-5627117 RHO GTPases Activate ROCKs
R-HSA-3928663 EPHA-mediated growth cone collapse
R-HSA-5627123 RHO GTPases activate PAKs
R-HSA-5625900 RHO GTPases activate CIT
R-HSA-5625740 RHO GTPases activate PKNs
R-HSA-400685 Sema4D in semaphorin signaling
R-HSA-195258 RHO GTPase Effectors
R-HSA-2682334 EPH-Ephrin signaling
R-HSA-373755 Semaphorin interactions
R-HSA-194315 Signaling by Rho GTPases
R-HSA-422475 Axon guidance
R-HSA-162582 Signal Transduction
R-HSA-1266738 Developmental Biology

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000379980.1, ENST00000379980.2, ENST00000379980.3, ENST00000379980.4, ENST00000379980.5, ENST00000379980.6, ENST00000379980.7, MYH10_HUMAN, NM_001375266, P35580, Q12989, Q149N3, Q149N4, Q16087, Q6PK16, uc010cnx.1, uc010cnx.2, uc010cnx.3, uc010cnx.4, uc010cnx.5
UCSC ID: ENST00000379980.8
RefSeq Accession: NM_001256095
Protein: P35580 (aka MYH10_HUMAN or MYHA_HUMAN)
CCDS: CCDS11144.1, CCDS58515.1, CCDS73984.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.