Human Gene KCNIP4 (ENST00000382152.7) Description and Page Index
  Description: Homo sapiens potassium voltage-gated channel interacting protein 4 (KCNIP4), transcript variant 1, mRNA. (from RefSeq NM_025221)
RefSeq Summary (NM_147182): This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. This protein member also interacts with presenilin. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].
Gencode Transcript: ENST00000382152.7
Gencode Gene: ENSG00000185774.16
Transcript (Including UTRs)
   Position: hg38 chr4:20,728,606-21,948,772 Size: 1,220,167 Total Exon Count: 9 Strand: -
Coding Region
   Position: hg38 chr4:20,730,082-21,948,631 Size: 1,218,550 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathways
Other NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr4:20,728,606-21,948,772)mRNA (may differ from genome)Protein (250 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
HPRDLynxMGIneXtProtOMIMPubMed
ReactomeStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: KCIP4_HUMAN
DESCRIPTION: RecName: Full=Kv channel-interacting protein 4; Short=KChIP4; AltName: Full=A-type potassium channel modulatory protein 4; AltName: Full=Calsenilin-like protein; AltName: Full=Potassium channel-interacting protein 4;
FUNCTION: Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Probably modulates channels density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents (By similarity).
SUBUNIT: Component of heteromultimeric potassium channels (By similarity). Interacts with KCND2. Interacts with KCND3, and the C-terminus of PSEN2 and probably PSEN1.
SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein (By similarity).
TISSUE SPECIFICITY: Predominantly expressed in brain.
DOMAIN: The KIS (K-channel inactivation suppressor) domain is required for converting A-type Kv4 current to a slowly inactivating delayed rectifier potassium current (By similarity).
SIMILARITY: Belongs to the recoverin family.
SIMILARITY: Contains 4 EF-hand domains.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 18.19 RPKM in Brain - Frontal Cortex (BA9)
Total median expression: 128.79 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -55.20141-0.391 Picture PostScript Text
3' UTR -293.401476-0.199 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011992 - EF-hand-like_dom
IPR018247 - EF_Hand_1_Ca_BS
IPR018249 - EF_HAND_2
IPR002048 - EF_hand_Ca-bd
IPR001125 - Recoverin

ModBase Predicted Comparative 3D Structure on Q6PIL6
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005244 voltage-gated ion channel activity
GO:0005267 potassium channel activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0015459 potassium channel regulator activity
GO:0046872 metal ion binding

Biological Process:
GO:0006811 ion transport
GO:0006813 potassium ion transport
GO:0034765 regulation of ion transmembrane transport
GO:0071805 potassium ion transmembrane transport
GO:0072659 protein localization to plasma membrane
GO:1901379 regulation of potassium ion transmembrane transport

Cellular Component:
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0008076 voltage-gated potassium channel complex
GO:0016020 membrane


-  Descriptions from all associated GenBank mRNAs
  BX648990 - Homo sapiens mRNA; cDNA DKFZp686J0484 (from clone DKFZp686J0484).
AK290998 - Homo sapiens cDNA FLJ75928 complete cds, highly similar to Homo sapiens Kv channel interacting protein 4 (KCNIP4), transcript variant 4, mRNA.
DQ148490 - Homo sapiens potassium channel interacting protein 4 mRNA, complete cds, alternatively spliced.
DQ148491 - Homo sapiens potassium channel interacting protein 4 mRNA, complete cds, alternatively spliced.
AK294188 - Homo sapiens cDNA FLJ59677 complete cds, highly similar to Kv channel-interacting protein 4.
DQ148492 - Homo sapiens potassium channel interacting protein 4 mRNA, complete cds, alternatively spliced.
AY118170 - Homo sapiens potassium channel-interacting protein KCHIP4.4 (KCNIP4) mRNA, complete cds, alternatively spliced.
DQ148489 - Homo sapiens potassium channel interacting protein 4 mRNA, complete cds, alternatively spliced.
AK289661 - Homo sapiens cDNA FLJ75905 complete cds, highly similar to Homo sapiens Kv channel interacting protein 4 (KCNIP4), transcript variant 2, mRNA.
AK289922 - Homo sapiens cDNA FLJ75910 complete cds, highly similar to Homo sapiens Kv channel interacting protein 4 (KCNIP4), transcript variant 1, mRNA.
BC032520 - Homo sapiens Kv channel interacting protein 4, mRNA (cDNA clone MGC:44947 IMAGE:5494835), complete cds.
AF367024 - Homo sapiens KCHIP4.2 (KCNIP4) mRNA, complete cds, alternatively spliced.
AF367023 - Homo sapiens KCHIP4.1 (KCNIP4) mRNA, complete cds, alternatively spliced.
AF453246 - Homo sapiens potassium channel interacting protein 4b short isoform mRNA, complete cds; alternatively spliced.
AY029176 - Homo sapiens KChIP4.3 variant (KCHIP4) mRNA, complete cds, alternatively spliced.
AF302044 - Homo sapiens calsenilin-like protein (CALP) mRNA, complete cds.
DQ148488 - Homo sapiens potassium channel interacting protein 4 mRNA, complete cds, alternatively spliced.
AF305072 - Homo sapiens calsenilin-like protein (CALP) mRNA, complete cds, alternatively spliced.
AK314058 - Homo sapiens cDNA, FLJ94724.
DQ148487 - Homo sapiens potassium channel interacting protein 4 mRNA, complete cds, alternatively spliced.
KJ899636 - Synthetic construct Homo sapiens clone ccsbBroadEn_09030 KCNIP4 gene, encodes complete protein.
EU446535 - Synthetic construct Homo sapiens clone IMAGE:100069863; IMAGE:100011744; FLH257045.01L Kv channel interacting protein 4 (KCNIP4) gene, encodes complete protein.
AB528608 - Synthetic construct DNA, clone: pF1KB5158, Homo sapiens KCNIP4 gene for Kv channel interacting protein 4, without stop codon, in Flexi system.
JD301479 - Sequence 282503 from Patent EP1572962.
JD495349 - Sequence 476373 from Patent EP1572962.
JD244097 - Sequence 225121 from Patent EP1572962.
JD503280 - Sequence 484304 from Patent EP1572962.
JD444877 - Sequence 425901 from Patent EP1572962.
JD529865 - Sequence 510889 from Patent EP1572962.
JD289277 - Sequence 270301 from Patent EP1572962.
JD377369 - Sequence 358393 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q6PIL6 (Reactome details) participates in the following event(s):

R-HSA-5577234 KCND tetramer:KCNIP tetramer transport K+ from cytosol to extrqcellular region
R-HSA-5576894 Phase 1 - inactivation of fast Na+ channels
R-HSA-5576891 Cardiac conduction
R-HSA-397014 Muscle contraction

-  Other Names for This Gene
  Alternate Gene Symbols: CALP, KCHIP4, KCIP4_HUMAN, NM_025221, Q3YAB8, Q3YAB9, Q3YAC0, Q3YAC1, Q3YAC2, Q4W5G8, Q6PIL6, Q8NEU0, Q9BWT2, Q9H294, Q9H2A4, uc062vny.1, uc062vny.2
UCSC ID: uc062vny.2
RefSeq Accession: NM_147182
Protein: Q6PIL6 (aka KCIP4_HUMAN)
CCDS: CCDS43216.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.