Human Gene KCNIP4 (ENST00000382152.7) Description and Page Index
Description: Homo sapiens potassium voltage-gated channel interacting protein 4 (KCNIP4), transcript variant 1, mRNA. (from RefSeq NM_025221) RefSeq Summary (NM_147182): This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. This protein member also interacts with presenilin. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000382152.7 Gencode Gene: ENSG00000185774.16 Transcript (Including UTRs) Position: hg38 chr4:20,728,606-21,948,772 Size: 1,220,167 Total Exon Count: 9 Strand: - Coding Region Position: hg38 chr4:20,730,082-21,948,631 Size: 1,218,550 Coding Exon Count: 9
ID:KCIP4_HUMAN DESCRIPTION: RecName: Full=Kv channel-interacting protein 4; Short=KChIP4; AltName: Full=A-type potassium channel modulatory protein 4; AltName: Full=Calsenilin-like protein; AltName: Full=Potassium channel-interacting protein 4; FUNCTION: Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Probably modulates channels density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents (By similarity). SUBUNIT: Component of heteromultimeric potassium channels (By similarity). Interacts with KCND2. Interacts with KCND3, and the C-terminus of PSEN2 and probably PSEN1. SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein (By similarity). TISSUE SPECIFICITY: Predominantly expressed in brain. DOMAIN: The KIS (K-channel inactivation suppressor) domain is required for converting A-type Kv4 current to a slowly inactivating delayed rectifier potassium current (By similarity). SIMILARITY: Belongs to the recoverin family. SIMILARITY: Contains 4 EF-hand domains.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q6PIL6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.