Human Gene BCAS3 (ENST00000390652.9) Description and Page Index
  Description: Homo sapiens BCAS3 microtubule associated cell migration factor (BCAS3), transcript variant 8, mRNA. (from RefSeq NM_001353146)
Gencode Transcript: ENST00000390652.9
Gencode Gene: ENSG00000141376.23
Transcript (Including UTRs)
   Position: hg38 chr17:60,677,889-61,392,838 Size: 714,950 Total Exon Count: 25 Strand: +
Coding Region
   Position: hg38 chr17:60,679,458-61,392,125 Size: 712,668 Coding Exon Count: 24 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2021-01-14 15:32:12

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:60,677,889-61,392,838)mRNA (may differ from genome)Protein (928 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
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Wikipedia

-  Comments and Description Text from UniProtKB
  ID: BCAS3_HUMAN
DESCRIPTION: RecName: Full=Breast carcinoma-amplified sequence 3; AltName: Full=GAOB1;
INTERACTION: P08670:VIM; NbExp=3; IntAct=EBI-6083685, EBI-353844;
SUBCELLULAR LOCATION: Nucleus (Potential).
TISSUE SPECIFICITY: Expressed in stomach, liver, lung, kidney, prostate, testis, thyroid gland, adrenal gland, brain, heart, skeletal muscle, colon, spleen, small intestine, placenta, blood leukocyte and mammary epithelial cells. Overexpressed in most breast cancer cell lines.
DEVELOPMENTAL STAGE: Fetal.
DISEASE: Note=A chromosomal aberration involving BCAS3 has been found in some breast carcinoma cell lines. Translocation t(17;20)(q23;q13) with BCAS4.
SIMILARITY: Belongs to the WD repeat BCAS3 family.
SIMILARITY: Contains 3 WD repeats.
SEQUENCE CAUTION: Sequence=AAF70324.1; Type=Frameshift; Positions=693; Sequence=AAL99634.1; Type=Erroneous initiation; Sequence=BAA90966.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB14078.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/BCAS3ID766.html";

-  MalaCards Disease Associations
  MalaCards Gene Search: BCAS3
Diseases sorted by gene-association score: breast cancer (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 5.98 RPKM in Testis
Total median expression: 172.77 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -12.5031-0.403 Picture PostScript Text
3' UTR -274.60713-0.385 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR022175 - BCAS3
IPR015943 - WD40/YVTN_repeat-like_dom
IPR001680 - WD40_repeat

Pfam Domains:
PF12490 - Breast carcinoma amplified sequence 3
PF00400 - WD domain, G-beta repeat

ModBase Predicted Comparative 3D Structure on Q9H6U6
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserNo orthologNo orthologNo orthologGenome BrowserNo ortholog
Gene Details     
Gene Sorter     
MGI   WormBase 
Protein Sequence   Protein Sequence 
Alignment   Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0010698 acetyltransferase activator activity
GO:0035035 histone acetyltransferase binding
GO:0035257 nuclear hormone receptor binding
GO:0042393 histone binding
GO:0048487 beta-tubulin binding

Biological Process:
GO:0001525 angiogenesis
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007030 Golgi organization
GO:0010595 positive regulation of endothelial cell migration
GO:0016192 vesicle-mediated transport
GO:0031023 microtubule organizing center organization
GO:0034260 negative regulation of GTPase activity
GO:0035148 tube formation
GO:0042594 response to starvation
GO:0043085 positive regulation of catalytic activity
GO:0043547 positive regulation of GTPase activity
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051491 positive regulation of filopodium assembly
GO:0051895 negative regulation of focal adhesion assembly
GO:0071391 cellular response to estrogen stimulus
GO:0090316 positive regulation of intracellular protein transport
GO:0090630 activation of GTPase activity
GO:2000114 regulation of establishment of cell polarity
GO:2000251 positive regulation of actin cytoskeleton reorganization

Cellular Component:
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005881 cytoplasmic microtubule
GO:0031252 cell leading edge
GO:0035327 transcriptionally active chromatin
GO:0045111 intermediate filament cytoskeleton
GO:0071944 cell periphery


-  Descriptions from all associated GenBank mRNAs
  AK304791 - Homo sapiens cDNA FLJ58237 complete cds, highly similar to Breast carcinoma amplified sequence 3.
AK225757 - Homo sapiens mRNA for Splice isoform 3 of Q9H6U6 variant, clone: FCC135C12.
BC017390 - Homo sapiens breast carcinoma amplified sequence 3, mRNA (cDNA clone IMAGE:4108577), partial cds.
AK314744 - Homo sapiens cDNA, FLJ95607, highly similar to Homo sapiens breast carcinoma amplified sequence 3 (BCAS3), mRNA.
AF361219 - Homo sapiens breast carcinoma amplified sequence 3 (BCAS3) mRNA, complete cds.
BC117275 - Homo sapiens breast carcinoma amplified sequence 3, mRNA (cDNA clone MGC:150884 IMAGE:40125826), complete cds.
BC143386 - Homo sapiens breast carcinoma amplified sequence 3, mRNA (cDNA clone MGC:176909 IMAGE:9051892), complete cds.
BC143387 - Homo sapiens breast carcinoma amplified sequence 3, mRNA (cDNA clone MGC:176910 IMAGE:9051893), complete cds.
AK025510 - Homo sapiens cDNA: FLJ21857 fis, clone HEP02294.
AK022526 - Homo sapiens cDNA FLJ12464 fis, clone NT2RM1000780.
AJ518105 - Homo sapiens partial mRNA for Maab2 protein.
AJ518836 - Homo sapiens partial mRNA for Maab3 protein.
AK023054 - Homo sapiens cDNA FLJ12992 fis, clone NT2RP3000149.
BC001250 - Homo sapiens breast carcinoma amplified sequence 3, mRNA (cDNA clone IMAGE:3458571), partial cds.
AL831895 - Homo sapiens mRNA; cDNA DKFZp547L188 (from clone DKFZp547L188).
AK000135 - Homo sapiens cDNA FLJ20128 fis, clone COL06181.
AF260268 - Homo sapiens GAOB1 mRNA, complete cds.
CU674626 - Synthetic construct Homo sapiens gateway clone IMAGE:100017160 5' read BCAS3 mRNA.
KJ902698 - Synthetic construct Homo sapiens clone ccsbBroadEn_12092 BCAS3 gene, encodes complete protein.
BC033220 - Homo sapiens breast carcinoma amplified sequence 3, mRNA (cDNA clone IMAGE:5018525), with apparent retained intron.
BC036280 - Homo sapiens breast carcinoma amplified sequence 3, mRNA (cDNA clone IMAGE:3917955).
BC013841 - Homo sapiens breast carcinoma amplified sequence 3, mRNA (cDNA clone IMAGE:3923751).
BC029983 - Homo sapiens breast carcinoma amplified sequence 3, mRNA (cDNA clone IMAGE:3917933).
JD399344 - Sequence 380368 from Patent EP1572962.
AF361221 - Homo sapiens breast carcinoma amplified sequence 4/3 fusion protein (BCAS4/BCAS3 fusion) mRNA, complete cds.
AJ511332 - Homo sapiens partial mRNA for Maab1 protein.
BX648103 - Homo sapiens mRNA; cDNA DKFZp686O1527 (from clone DKFZp686O1527).
JD163680 - Sequence 144704 from Patent EP1572962.
JD273552 - Sequence 254576 from Patent EP1572962.
JD393930 - Sequence 374954 from Patent EP1572962.
JD272191 - Sequence 253215 from Patent EP1572962.
JD153968 - Sequence 134992 from Patent EP1572962.
JD495292 - Sequence 476316 from Patent EP1572962.
JD439896 - Sequence 420920 from Patent EP1572962.
JD136566 - Sequence 117590 from Patent EP1572962.
JD117871 - Sequence 98895 from Patent EP1572962.
JD545712 - Sequence 526736 from Patent EP1572962.
JD141697 - Sequence 122721 from Patent EP1572962.
JD382657 - Sequence 363681 from Patent EP1572962.
JD177892 - Sequence 158916 from Patent EP1572962.
JD378184 - Sequence 359208 from Patent EP1572962.
JD396906 - Sequence 377930 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: BCAS3_HUMAN, ENST00000390652.1, ENST00000390652.2, ENST00000390652.3, ENST00000390652.4, ENST00000390652.5, ENST00000390652.6, ENST00000390652.7, ENST00000390652.8, NM_001353146, Q17RM0, Q6KF21, Q8IXI6, Q8NDR8, Q8TDL9, Q8TDM1, Q8WY55, Q9BVF0, Q9H6U6, Q9H957, Q9H9Y9, Q9NXP4, uc002iyv.1, uc002iyv.2, uc002iyv.3, uc002iyv.4, uc002iyv.5
UCSC ID: ENST00000390652.9
RefSeq Accession: NM_001099432
Protein: Q9H6U6 (aka BCAS3_HUMAN or BCS3_HUMAN)
CCDS: CCDS11626.1, CCDS45749.1, CCDS82176.1, CCDS82178.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.