Human Gene GULP1 (ENST00000409609.5) Description and Page Index
Description: May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6. (from UniProt Q9UBP9) Gencode Transcript: ENST00000409609.5 Gencode Gene: ENSG00000144366.16 Transcript (Including UTRs) Position: hg38 chr2:188,293,818-188,594,281 Size: 300,464 Total Exon Count: 12 Strand: + Coding Region Position: hg38 chr2:188,477,703-188,594,011 Size: 116,309 Coding Exon Count: 10
ID:GULP1_HUMAN DESCRIPTION: RecName: Full=PTB domain-containing engulfment adapter protein 1; AltName: Full=Cell death protein 6 homolog; AltName: Full=PTB domain adapter protein CED-6; AltName: Full=Protein GULP; FUNCTION: May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6. SUBUNIT: Homodimer. Interacts with clathrin. Interacts with GDP- bound ARF6, but not with GTP-bound ARF6. Part of a complex composed of GULP1, ACAP1 and ARF6. Interacts with ACAP1, LRP1, MEGF10 and STAB2. SUBCELLULAR LOCATION: Cytoplasm. Note=May associate with the cytoplasmic side of the plasma membrane and early endosomes. TISSUE SPECIFICITY: Widely expressed. Detected in macrophages, pancreas, kidney, skeletal muscle, heart, colon, intestine, lung, placenta and ovary. SIMILARITY: Belongs to the ced-6 family. SIMILARITY: Contains 1 PID domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UBP9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.