Human Gene GULP1 (ENST00000409609.5) Description and Page Index
  Description: May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6. (from UniProt Q9UBP9)
Gencode Transcript: ENST00000409609.5
Gencode Gene: ENSG00000144366.16
Transcript (Including UTRs)
   Position: hg38 chr2:188,293,818-188,594,281 Size: 300,464 Total Exon Count: 12 Strand: +
Coding Region
   Position: hg38 chr2:188,477,703-188,594,011 Size: 116,309 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Methods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:188,293,818-188,594,281)mRNA (may differ from genome)Protein (304 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblExonPrimerGeneCardsHGNCHPRD
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-  Comments and Description Text from UniProtKB
  ID: GULP1_HUMAN
DESCRIPTION: RecName: Full=PTB domain-containing engulfment adapter protein 1; AltName: Full=Cell death protein 6 homolog; AltName: Full=PTB domain adapter protein CED-6; AltName: Full=Protein GULP;
FUNCTION: May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6.
SUBUNIT: Homodimer. Interacts with clathrin. Interacts with GDP- bound ARF6, but not with GTP-bound ARF6. Part of a complex composed of GULP1, ACAP1 and ARF6. Interacts with ACAP1, LRP1, MEGF10 and STAB2.
SUBCELLULAR LOCATION: Cytoplasm. Note=May associate with the cytoplasmic side of the plasma membrane and early endosomes.
TISSUE SPECIFICITY: Widely expressed. Detected in macrophages, pancreas, kidney, skeletal muscle, heart, colon, intestine, lung, placenta and ovary.
SIMILARITY: Belongs to the ced-6 family.
SIMILARITY: Contains 1 PID domain.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • D001564 Benzo(a)pyrene
  • D002945 Cisplatin
  • C006253 pirinixic acid
  • C015559 trimellitic anhydride
  • C049325 1,2-dithiol-3-thione
  • C495626 14-deoxy-11,12-didehydroandrographolide
  • C111118 2',3,3',4',5-pentachloro-4-hydroxybiphenyl
  • C029497 2,3-bis(3'-hydroxybenzyl)butyrolactone
  • C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester
  • D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
          more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 5.86 RPKM in Artery - Aorta
Total median expression: 98.09 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -193.50747-0.259 Picture PostScript Text
3' UTR -35.40270-0.131 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011993 - PH_like_dom
IPR006020 - PTyr_interaction_dom

Pfam Domains:
PF00640 - Phosphotyrosine interaction domain (PTB/PID)

ModBase Predicted Comparative 3D Structure on Q9UBP9
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologGenome BrowserGenome BrowserNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsemblEnsemblWormBase 
Protein SequenceProtein Sequence Protein SequenceProtein Sequence 
AlignmentAlignment AlignmentAlignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity

Biological Process:
GO:0006869 lipid transport
GO:0006909 phagocytosis
GO:0006911 phagocytosis, engulfment
GO:0006915 apoptotic process
GO:0007165 signal transduction

Cellular Component:
GO:0005737 cytoplasm


-  Descriptions from all associated GenBank mRNAs
  AK055718 - Homo sapiens cDNA FLJ31156 fis, clone IMR322001710, highly similar to Homo sapiens PTB domain adaptor protein CED-6 mRNA.
AK314498 - Homo sapiens cDNA, FLJ95313, Homo sapiens GULP, engulfment adaptor PTB domain containing 1(GULP1), mRNA.
BC001103 - Homo sapiens GULP, engulfment adaptor PTB domain containing 1, mRNA (cDNA clone MGC:742 IMAGE:3505407), complete cds.
AK298626 - Homo sapiens cDNA FLJ57758 complete cds, highly similar to Homo sapiens GULP, engulfment adaptor PTB domain containing 1 (GULP1), mRNA.
BC068525 - Homo sapiens GULP, engulfment adaptor PTB domain containing 1, mRNA (cDNA clone IMAGE:30335791), with apparent retained intron.
AF200715 - Homo sapiens PTB domain adaptor protein CED-6 mRNA, complete cds.
AF191771 - Homo sapiens CED-6 protein (CED-6) mRNA, complete cds.
AF075014 - Homo sapiens full length insert cDNA YI23D12.
AK023668 - Homo sapiens cDNA FLJ13606 fis, clone PLACE1010579, highly similar to Homo sapiens GULP, engulfment adaptor PTB domain containing 1 (GULP1), mRNA.
KJ902594 - Synthetic construct Homo sapiens clone ccsbBroadEn_11988 GULP1 gene, encodes complete protein.
AB463712 - Synthetic construct DNA, clone: pF1KB6401, Homo sapiens GULP1 gene for GULP, engulfment adaptor PTB domain containing 1, without stop codon, in Flexi system.
JD155208 - Sequence 136232 from Patent EP1572962.
JD260538 - Sequence 241562 from Patent EP1572962.
AB209890 - Homo sapiens mRNA for GULP, engulfment adaptor PTB domain containing 1 variant protein.
AL080142 - Homo sapiens mRNA; cDNA DKFZp434N103 (from clone DKFZp434N103).
AK130507 - Homo sapiens cDNA FLJ26997 fis, clone SLV04684.
JD237905 - Sequence 218929 from Patent EP1572962.
JD284310 - Sequence 265334 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: AK023668, B2RB51, CED6, D3DPH1, GULP, GULP1_HUMAN, Q53PC1, Q53RF3, Q9BVL3, Q9UBP9, uc061qnk.1
UCSC ID: uc061qnk.1
RefSeq Accession: NR_045563
Protein: Q9UBP9 (aka GULP1_HUMAN)
CCDS: CCDS2295.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.