Human Gene RIC1 (ENST00000414202.7) Description and Page Index
  Description: Homo sapiens RIC1 homolog, RAB6A GEF complex partner 1 (RIC1), transcript variant 1, mRNA. (from RefSeq NM_020829)
Gencode Transcript: ENST00000414202.7
Gencode Gene: ENSG00000107036.12
Transcript (Including UTRs)
   Position: hg38 chr9:5,629,107-5,776,557 Size: 147,451 Total Exon Count: 26 Strand: +
Coding Region
   Position: hg38 chr9:5,629,310-5,774,246 Size: 144,937 Coding Exon Count: 26 

Page IndexSequence and LinksUniProtKB CommentsRNA-Seq ExpressionMicroarray ExpressionRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther Names
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr9:5,629,107-5,776,557)mRNA (may differ from genome)Protein (1423 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaBioGPSEnsembl
Entrez GeneExonPrimerGeneCardsHPRDLynxMGI
neXtProtOMIMPubMedReactomeStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Protein RIC1 homolog; AltName: Full=Connexin-43-interacting protein of 150 kDa;
FUNCTION: Required for phosphorylation and localization of GJA1.
SUBUNIT: Interacts with GJA1.
SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (Potential).
TISSUE SPECIFICITY: Present in kidney and various cell lines (at protein level). Widely expressed at low level.
SIMILARITY: Belongs to the RIC1 family.
SIMILARITY: Contains 2 WD repeats.
SEQUENCE CAUTION: Sequence=AAI36617.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAI44297.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB14150.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAE16982.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAB66809.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAI95003.1; Type=Erroneous gene model prediction; Sequence=CAI95004.1; Type=Erroneous gene model prediction;

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 19.98 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 289.55 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -116.80203-0.575 Picture PostScript Text
3' UTR -565.302311-0.245 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR009771 - Ribosome_control_1
IPR015943 - WD40/YVTN_repeat-like_dom
IPR017986 - WD40_repeat_dom

Pfam Domains:
PF07064 - RIC1

ModBase Predicted Comparative 3D Structure on Q4ADV7
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologGenome BrowserGenome BrowserNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence Protein SequenceProtein Sequence 
AlignmentAlignment AlignmentAlignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0017112 Rab guanyl-nucleotide exchange factor activity
GO:0017137 Rab GTPase binding

Biological Process:
GO:0006886 intracellular protein transport
GO:0042147 retrograde transport, endosome to Golgi
GO:0043547 positive regulation of GTPase activity
GO:1903363 negative regulation of cellular protein catabolic process

Cellular Component:
GO:0000139 Golgi membrane
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0032588 trans-Golgi network membrane
GO:0032991 macromolecular complex
GO:0034066 RIC1-RGP1 guanyl-nucleotide exchange factor complex

-  Descriptions from all associated GenBank mRNAs
  LF385283 - JP 2014500723-A/192786: Polycomb-Associated Non-Coding RNAs.
MA620860 - JP 2018138019-A/192786: Polycomb-Associated Non-Coding RNAs.
LF385475 - JP 2014500723-A/192978: Polycomb-Associated Non-Coding RNAs.
MA621052 - JP 2018138019-A/192978: Polycomb-Associated Non-Coding RNAs.
AL136875 - Homo sapiens mRNA; cDNA DKFZp434D105 (from clone DKFZp434D105).
BC136616 - Homo sapiens KIAA1432, mRNA (cDNA clone MGC:168229 IMAGE:9020606), complete cds.
BC144296 - Homo sapiens KIAA1432, mRNA (cDNA clone MGC:177833 IMAGE:9052816), complete cds.
AB205401 - Homo sapiens CIP150 mRNA for connexin43-interacting protein of 150 kDa, complete cds.
AK124394 - Homo sapiens cDNA FLJ42403 fis, clone ASTRO3000177, weakly similar to Drosophila melanogaster BcDNA.GH03694 (BcDNA.GH03694) mRNA.
AK022642 - Homo sapiens cDNA FLJ12580 fis, clone NT2RM4001116, weakly similar to HYPOTHETICAL 216.3 KD PROTEIN R06F6.8 IN CHROMOSOME II.
AB037853 - Homo sapiens mRNA for KIAA1432 protein, partial cds.
AB527173 - Synthetic construct DNA, clone: pF1KA1432, Homo sapiens KIAA1432 gene for KIAA1432, without stop codon, in Flexi system.
AK074150 - Homo sapiens mRNA for FLJ00223 protein.
BC030576 - Homo sapiens KIAA1432, mRNA (cDNA clone IMAGE:4077122), partial cds.
JD109793 - Sequence 90817 from Patent EP1572962.
JD468950 - Sequence 449974 from Patent EP1572962.
JD428544 - Sequence 409568 from Patent EP1572962.
JD206490 - Sequence 187514 from Patent EP1572962.
JD301616 - Sequence 282640 from Patent EP1572962.
JD154748 - Sequence 135772 from Patent EP1572962.
JD315186 - Sequence 296210 from Patent EP1572962.
LF345332 - JP 2014500723-A/152835: Polycomb-Associated Non-Coding RNAs.
MA580909 - JP 2018138019-A/152835: Polycomb-Associated Non-Coding RNAs.
JD079965 - Sequence 60989 from Patent EP1572962.
JD186607 - Sequence 167631 from Patent EP1572962.
LF345335 - JP 2014500723-A/152838: Polycomb-Associated Non-Coding RNAs.
MA580912 - JP 2018138019-A/152838: Polycomb-Associated Non-Coding RNAs.
JD091887 - Sequence 72911 from Patent EP1572962.
LF345342 - JP 2014500723-A/152845: Polycomb-Associated Non-Coding RNAs.
MA580919 - JP 2018138019-A/152845: Polycomb-Associated Non-Coding RNAs.
LF345345 - JP 2014500723-A/152848: Polycomb-Associated Non-Coding RNAs.
MA580922 - JP 2018138019-A/152848: Polycomb-Associated Non-Coding RNAs.
DQ570742 - Homo sapiens piRNA piR-30854, complete sequence.
LF345346 - JP 2014500723-A/152849: Polycomb-Associated Non-Coding RNAs.
MA580923 - JP 2018138019-A/152849: Polycomb-Associated Non-Coding RNAs.
LF345348 - JP 2014500723-A/152851: Polycomb-Associated Non-Coding RNAs.
MA580925 - JP 2018138019-A/152851: Polycomb-Associated Non-Coding RNAs.
BC023535 - Homo sapiens KIAA1432, mRNA (cDNA clone IMAGE:4123047), partial cds.
BC041044 - Homo sapiens KIAA1432, mRNA (cDNA clone IMAGE:4901507), partial cds.
LF345349 - JP 2014500723-A/152852: Polycomb-Associated Non-Coding RNAs.
MA580926 - JP 2018138019-A/152852: Polycomb-Associated Non-Coding RNAs.
JD051695 - Sequence 32719 from Patent EP1572962.
JD344563 - Sequence 325587 from Patent EP1572962.
JD508053 - Sequence 489077 from Patent EP1572962.
JD327892 - Sequence 308916 from Patent EP1572962.
JD296964 - Sequence 277988 from Patent EP1572962.
JD349000 - Sequence 330024 from Patent EP1572962.
JD109320 - Sequence 90344 from Patent EP1572962.
JD074620 - Sequence 55644 from Patent EP1572962.
JD110127 - Sequence 91151 from Patent EP1572962.
LF345350 - JP 2014500723-A/152853: Polycomb-Associated Non-Coding RNAs.
MA580927 - JP 2018138019-A/152853: Polycomb-Associated Non-Coding RNAs.
JD312923 - Sequence 293947 from Patent EP1572962.
JD202460 - Sequence 183484 from Patent EP1572962.
JD060989 - Sequence 42013 from Patent EP1572962.
JD090504 - Sequence 71528 from Patent EP1572962.
JD435571 - Sequence 416595 from Patent EP1572962.
JD154721 - Sequence 135745 from Patent EP1572962.
JD168025 - Sequence 149049 from Patent EP1572962.
JD303451 - Sequence 284475 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q4ADV7 (Reactome details) participates in the following event(s):

R-HSA-6811428 RIC1:RGP1 recruits RAB6:GDP to the TGN
R-HSA-8847887 RAB33B:GTP binds RIC1:RGP1
R-HSA-6811431 RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles
R-HSA-6811429 RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange
R-HSA-8876193 RIC1-RGP1 exchanges GTP for GDP on RAB6
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network
R-HSA-6811438 Intra-Golgi traffic
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs
R-HSA-199991 Membrane Trafficking
R-HSA-9007101 Rab regulation of trafficking
R-HSA-5653656 Vesicle-mediated transport

-  Other Names for This Gene
  Alternate Gene Symbols: B2RN24, B7ZM67, CIP150, G5E932, KIAA1432, NM_020829, Q4ADV7, Q4VXJ8, Q4VXJ9, Q76MT5, Q8N6E0, Q8TEH4, Q9H0A5, Q9H9S1, RIC1_HUMAN, uc003zji.1, uc003zji.2, uc003zji.3, uc003zji.4, uc003zji.5, uc003zji.6
UCSC ID: uc003zji.6
RefSeq Accession: NM_020829
Protein: Q4ADV7 (aka RIC1_HUMAN)
CCDS: CCDS34982.2, CCDS75811.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.