Human Gene TMEM120B (ENST00000449592.7) Description and Page Index
  Description: Homo sapiens transmembrane protein 120B (TMEM120B), mRNA. (from RefSeq NM_001080825)
Gencode Transcript: ENST00000449592.7
Gencode Gene: ENSG00000188735.13
Transcript (Including UTRs)
   Position: hg38 chr12:121,712,752-121,782,068 Size: 69,317 Total Exon Count: 12 Strand: +
Coding Region
   Position: hg38 chr12:121,712,896-121,775,722 Size: 62,827 Coding Exon Count: 12 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Data last updated at UCSC: 2021-01-14 15:32:12

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr12:121,712,752-121,782,068)mRNA (may differ from genome)Protein (339 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaBioGPSCGAP
EnsemblEntrez GeneExonPrimerGeneCardsHGNCHPRD

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Transmembrane protein 120B;
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).
SIMILARITY: Belongs to the TMEM120 family.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 37.53 RPKM in Brain - Cerebellum
Total median expression: 320.10 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -78.30144-0.544 Picture PostScript Text
3' UTR -2997.106346-0.472 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR012926 - TMPIT

Pfam Domains:
PF07851 - TMPIT-like protein

ModBase Predicted Comparative 3D Structure on A0PK00
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003674 molecular_function
GO:0005515 protein binding

Biological Process:
GO:0008150 biological_process
GO:0045444 fat cell differentiation
GO:0051291 protein heterooligomerization

Cellular Component:
GO:0005575 cellular_component
GO:0005634 nucleus
GO:0005637 nuclear inner membrane
GO:0016020 membrane
GO:0016021 integral component of membrane

-  Descriptions from all associated GenBank mRNAs
  AK126568 - Homo sapiens cDNA FLJ44605 fis, clone BRACE2003628, moderately similar to Homo sapiens transmembrane protein induced by tumor necrosis factor alpha (TMPIT), mRNA.
BC127768 - Homo sapiens transmembrane protein 120B, mRNA (cDNA clone MGC:157879 IMAGE:40127741), complete cds.
BC127769 - Homo sapiens transmembrane protein 120B, mRNA (cDNA clone MGC:157880 IMAGE:40127743), complete cds.
KJ895578 - Synthetic construct Homo sapiens clone ccsbBroadEn_04972 TMEM120B gene, encodes complete protein.
BC035884 - Homo sapiens, clone IMAGE:4991579, mRNA.
BX648084 - Homo sapiens mRNA; cDNA DKFZp686L016 (from clone DKFZp686L016).
JD396264 - Sequence 377288 from Patent EP1572962.
JD406086 - Sequence 387110 from Patent EP1572962.
JD404590 - Sequence 385614 from Patent EP1572962.
JD151285 - Sequence 132309 from Patent EP1572962.
JD494440 - Sequence 475464 from Patent EP1572962.
JD322670 - Sequence 303694 from Patent EP1572962.
JD285760 - Sequence 266784 from Patent EP1572962.
JD099171 - Sequence 80195 from Patent EP1572962.
AK123181 - Homo sapiens cDNA FLJ41186 fis, clone BRACE2044105.
JD275239 - Sequence 256263 from Patent EP1572962.
JD218866 - Sequence 199890 from Patent EP1572962.
JD492423 - Sequence 473447 from Patent EP1572962.
JD304935 - Sequence 285959 from Patent EP1572962.
JD441219 - Sequence 422243 from Patent EP1572962.
JD219826 - Sequence 200850 from Patent EP1572962.
JD488439 - Sequence 469463 from Patent EP1572962.
JD494308 - Sequence 475332 from Patent EP1572962.
JD428429 - Sequence 409453 from Patent EP1572962.
JD481991 - Sequence 463015 from Patent EP1572962.
JD242315 - Sequence 223339 from Patent EP1572962.
JD078534 - Sequence 59558 from Patent EP1572962.
JD225204 - Sequence 206228 from Patent EP1572962.
JD225203 - Sequence 206227 from Patent EP1572962.
JD518598 - Sequence 499622 from Patent EP1572962.
JD108771 - Sequence 89795 from Patent EP1572962.
JD076845 - Sequence 57869 from Patent EP1572962.
JD511964 - Sequence 492988 from Patent EP1572962.
JD252111 - Sequence 233135 from Patent EP1572962.
JD541127 - Sequence 522151 from Patent EP1572962.
JD438959 - Sequence 419983 from Patent EP1572962.
JD070108 - Sequence 51132 from Patent EP1572962.
JD041721 - Sequence 22745 from Patent EP1572962.
JD203807 - Sequence 184831 from Patent EP1572962.
JD505644 - Sequence 486668 from Patent EP1572962.
JD330833 - Sequence 311857 from Patent EP1572962.
JD374370 - Sequence 355394 from Patent EP1572962.
JD095592 - Sequence 76616 from Patent EP1572962.
JD560660 - Sequence 541684 from Patent EP1572962.
JD560661 - Sequence 541685 from Patent EP1572962.
JD476673 - Sequence 457697 from Patent EP1572962.
JD383761 - Sequence 364785 from Patent EP1572962.
JD069703 - Sequence 50727 from Patent EP1572962.
JD496949 - Sequence 477973 from Patent EP1572962.
JD325596 - Sequence 306620 from Patent EP1572962.
JD546011 - Sequence 527035 from Patent EP1572962.
JD190159 - Sequence 171183 from Patent EP1572962.
JD384687 - Sequence 365711 from Patent EP1572962.
JD232095 - Sequence 213119 from Patent EP1572962.
AK309447 - Homo sapiens cDNA, FLJ99488.
JD410075 - Sequence 391099 from Patent EP1572962.
JD410076 - Sequence 391100 from Patent EP1572962.
JD096693 - Sequence 77717 from Patent EP1572962.
BC018721 - Homo sapiens ras homolog gene family, member F (in filopodia), mRNA (cDNA clone IMAGE:3350340), with apparent retained intron.
AK022629 - Homo sapiens cDNA FLJ12567 fis, clone NT2RM4000855.
BC032529 - Homo sapiens cDNA clone IMAGE:5502698.
BC069021 - Homo sapiens cDNA clone IMAGE:6461761, partial cds.
JD146008 - Sequence 127032 from Patent EP1572962.
BC043395 - Homo sapiens, clone IMAGE:5538723, mRNA.
JD442937 - Sequence 423961 from Patent EP1572962.
JD335342 - Sequence 316366 from Patent EP1572962.
JD457150 - Sequence 438174 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A0PK00, A0PK01, B3KX33, ENST00000449592.1, ENST00000449592.2, ENST00000449592.3, ENST00000449592.4, ENST00000449592.5, ENST00000449592.6, NM_001080825, T120B_HUMAN, uc001ubc.1, uc001ubc.2, uc001ubc.3, uc001ubc.4, uc001ubc.5, uc001ubc.6
UCSC ID: ENST00000449592.7
RefSeq Accession: NM_001080825
Protein: A0PK00 (aka T120B_HUMAN)
CCDS: CCDS41852.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.