Human Gene NME7 (ENST00000472647.5) from GENCODE V44
Description: Homo sapiens NME/NM23 family member 7 (NME7), transcript variant 2, mRNA. (from RefSeq NM_197972) RefSeq Summary (NM_197972): This gene encodes a member of the non-metastatic expressed family of nucleoside diphosphate kinases. Members of this family are enzymes that catalyzes phosphate transfer from nucleoside triphosphates to nucleoside diphosphates. This protein contains two kinase domains, one of which is involved in autophosphorylation and the other may be inactive. This protein localizes to the centrosome and functions as a component of the gamma-tubulin ring complex which plays a role in microtubule organization. Mutations in this gene may be associated with venous thromboembolism. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]. Gencode Transcript: ENST00000472647.5 Gencode Gene: ENSG00000143156.14 Transcript (Including UTRs) Position: hg38 chr1:169,132,531-169,367,946 Size: 235,416 Total Exon Count: 12 Strand: - Coding Region Position: hg38 chr1:169,132,785-169,324,395 Size: 191,611 Coding Exon Count: 11
ID:NDK7_HUMAN DESCRIPTION: RecName: Full=Nucleoside diphosphate kinase 7; Short=NDK 7; Short=NDP kinase 7; EC=22.214.171.124; AltName: Full=nm23-H7; FUNCTION: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. CATALYTIC ACTIVITY: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate. COFACTOR: Magnesium (By similarity). SIMILARITY: Belongs to the NDK family. SIMILARITY: Contains 1 DM10 domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9Y5B8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.