Human Gene NME7 (ENST00000472647.5) from GENCODE V44
  Description: Homo sapiens NME/NM23 family member 7 (NME7), transcript variant 2, mRNA. (from RefSeq NM_197972)
RefSeq Summary (NM_197972): This gene encodes a member of the non-metastatic expressed family of nucleoside diphosphate kinases. Members of this family are enzymes that catalyzes phosphate transfer from nucleoside triphosphates to nucleoside diphosphates. This protein contains two kinase domains, one of which is involved in autophosphorylation and the other may be inactive. This protein localizes to the centrosome and functions as a component of the gamma-tubulin ring complex which plays a role in microtubule organization. Mutations in this gene may be associated with venous thromboembolism. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016].
Gencode Transcript: ENST00000472647.5
Gencode Gene: ENSG00000143156.14
Transcript (Including UTRs)
   Position: hg38 chr1:169,132,531-169,367,946 Size: 235,416 Total Exon Count: 12 Strand: -
Coding Region
   Position: hg38 chr1:169,132,785-169,324,395 Size: 191,611 Coding Exon Count: 11 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr1:169,132,531-169,367,946)mRNA (may differ from genome)Protein (340 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Nucleoside diphosphate kinase 7; Short=NDK 7; Short=NDP kinase 7; EC=; AltName: Full=nm23-H7;
FUNCTION: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
CATALYTIC ACTIVITY: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.
COFACTOR: Magnesium (By similarity).
SIMILARITY: Belongs to the NDK family.
SIMILARITY: Contains 1 DM10 domain.

-  Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

-  MalaCards Disease Associations
  MalaCards Gene Search: NME7
Diseases sorted by gene-association score: dextrocardia with situs inversus* (247)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 10.57 RPKM in Pituitary
Total median expression: 230.96 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -104.80313-0.335 Picture PostScript Text
3' UTR -57.90254-0.228 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011410 - NDK7
IPR001564 - Nucleoside_diP_kinase
IPR006602 - Uncharacterised_DM10

Pfam Domains:
PF00334 - Nucleoside diphosphate kinase

ModBase Predicted Comparative 3D Structure on Q9Y5B8
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0004550 nucleoside diphosphate kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0046872 metal ion binding

Biological Process:
GO:0006165 nucleoside diphosphate phosphorylation
GO:0006183 GTP biosynthetic process
GO:0006228 UTP biosynthetic process
GO:0006241 CTP biosynthetic process
GO:0009117 nucleotide metabolic process
GO:0015949 nucleobase-containing small molecule interconversion
GO:0016310 phosphorylation

Cellular Component:
GO:0005813 centrosome
GO:0005829 cytosol

-  Descriptions from all associated GenBank mRNAs
  LF383654 - JP 2014500723-A/191157: Polycomb-Associated Non-Coding RNAs.
MA619231 - JP 2018138019-A/191157: Polycomb-Associated Non-Coding RNAs.
AF153191 - Homo sapiens nm23-H7 (NME7) mRNA, complete cds.
BC006983 - Homo sapiens non-metastatic cells 7, protein expressed in (nucleoside-diphosphate kinase), mRNA (cDNA clone MGC:12203 IMAGE:3997152), complete cds.
AK290701 - Homo sapiens cDNA FLJ76131 complete cds, highly similar to Homo sapiens non-metastatic cells 7, protein expressed in (nucleoside-diphosphate kinase) (NME7), transcript variant 1, mRNA.
AK094513 - Homo sapiens cDNA FLJ37194 fis, clone BRALZ2005467, highly similar to Nucleoside diphosphate kinase 7 (EC
AK301917 - Homo sapiens cDNA FLJ58336 complete cds, highly similar to Nucleoside diphosphate kinase 7 (EC
KJ905462 - Synthetic construct Homo sapiens clone ccsbBroadEn_15052 NME7 gene, encodes complete protein.
AB463934 - Synthetic construct DNA, clone: pF1KB8210, Homo sapiens NME7 gene for non-metastatic cells 7, protein expressed in, without stop codon, in Flexi system.
AB209049 - Homo sapiens mRNA for nucleoside-diphosphate kinase 7 isoform a variant protein.
LF205430 - JP 2014500723-A/12933: Polycomb-Associated Non-Coding RNAs.
MA441007 - JP 2018138019-A/12933: Polycomb-Associated Non-Coding RNAs.
JD524193 - Sequence 505217 from Patent EP1572962.
LF320432 - JP 2014500723-A/127935: Polycomb-Associated Non-Coding RNAs.
MA556009 - JP 2018138019-A/127935: Polycomb-Associated Non-Coding RNAs.
JD374656 - Sequence 355680 from Patent EP1572962.
LF320419 - JP 2014500723-A/127922: Polycomb-Associated Non-Coding RNAs.
MA555996 - JP 2018138019-A/127922: Polycomb-Associated Non-Coding RNAs.
LF320416 - JP 2014500723-A/127919: Polycomb-Associated Non-Coding RNAs.
MA555993 - JP 2018138019-A/127919: Polycomb-Associated Non-Coding RNAs.
LF320411 - JP 2014500723-A/127914: Polycomb-Associated Non-Coding RNAs.
MA555988 - JP 2018138019-A/127914: Polycomb-Associated Non-Coding RNAs.
LF320408 - JP 2014500723-A/127911: Polycomb-Associated Non-Coding RNAs.
MA555985 - JP 2018138019-A/127911: Polycomb-Associated Non-Coding RNAs.
LF320407 - JP 2014500723-A/127910: Polycomb-Associated Non-Coding RNAs.
MA555984 - JP 2018138019-A/127910: Polycomb-Associated Non-Coding RNAs.
LF320406 - JP 2014500723-A/127909: Polycomb-Associated Non-Coding RNAs.
MA555983 - JP 2018138019-A/127909: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa00230 - Purine metabolism
hsa00240 - Pyrimidine metabolism
hsa01100 - Metabolic pathways

Reactome (by CSHL, EBI, and GO)

Protein Q9Y5B8 (Reactome details) participates in the following event(s):

R-HSA-6806877 NMEs phosphorylate NDPs to NTPs
R-HSA-499943 Interconversion of nucleotide di- and triphosphates
R-HSA-15869 Metabolism of nucleotides
R-HSA-1430728 Metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: A8K3T6, A8MY09, B3KSW9, ENST00000472647.1, ENST00000472647.2, ENST00000472647.3, ENST00000472647.4, NDK7_HUMAN, NM_197972, Q5TGZ4, Q9Y5B8, uc001gft.1, uc001gft.2, uc001gft.3, uc001gft.4, uc001gft.5
UCSC ID: ENST00000472647.5
RefSeq Accession: NM_197972
Protein: Q9Y5B8 (aka NDK7_HUMAN)
CCDS: CCDS44274.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.