Human Gene RPL22 (ENST00000497965.5) from GENCODE V44
  Description: ribosomal protein L22 (from HGNC RPL22)
RefSeq Summary (NM_000983): Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 60S subunit. The protein belongs to the L22E family of ribosomal proteins. Its initiating methionine residue is post-translationally removed. The protein can bind specifically to Epstein-Barr virus-encoded RNAs (EBERs) 1 and 2. The mouse protein has been shown to be capable of binding to heparin. Transcript variants utilizing alternative polyA signals exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. It was previously thought that this gene mapped to 3q26 and that it was fused to the acute myeloid leukemia 1 (AML1) gene located at 21q22 in some therapy-related myelodysplastic syndrome patients with 3;21 translocations; however, these fusions actually involve a ribosomal protein L22 pseudogene located at 3q26, and this gene actually maps to 1p36.3-p36.2. [provided by RefSeq, Jul 2008].
Gencode Transcript: ENST00000497965.5
Gencode Gene: ENSG00000116251.11
Transcript (Including UTRs)
   Position: hg38 chr1:6,186,615-6,200,842 Size: 14,228 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg38 chr1:6,186,672-6,197,669 Size: 10,998 Coding Exon Count: 3 

Page IndexSequence and LinksPrimersMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsPathwaysOther Names
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr1:6,186,615-6,200,842)mRNA (may differ from genome)Protein (95 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold

-  Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

-  MalaCards Disease Associations
  MalaCards Gene Search: RPL22
Diseases sorted by gene-association score: myasthenic syndrome, congenital, 5 (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 185.80 RPKM in Ovary
Total median expression: 4047.25 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -140.70441-0.319 Picture PostScript Text
3' UTR -6.5057-0.114 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Descriptions from all associated GenBank mRNAs
  AK097075 - Homo sapiens cDNA FLJ39756 fis, clone SMINT2018681, moderately similar to 60S RIBOSOMAL PROTEIN L22.
BC046108 - Homo sapiens cDNA clone IMAGE:5763199, **** WARNING: chimeric clone ****.
BC058887 - Homo sapiens ribosomal protein L22, mRNA (cDNA clone MGC:64893 IMAGE:6141451), complete cds.
BC066314 - Homo sapiens ribosomal protein L22, mRNA (cDNA clone MGC:87176 IMAGE:5303658), complete cds.
BC035566 - Homo sapiens ribosomal protein L22, mRNA (cDNA clone MGC:40344 IMAGE:5109124), complete cds.
X59357 - Human mRNA for Epstein-Barr virus small RNAs (EBERs)associated protein (EAP).
D17652 - Homo sapiens mRNA for HBp15/L22, complete cds.
JD056778 - Sequence 37802 from Patent EP1572962.
JD042649 - Sequence 23673 from Patent EP1572962.
CR456873 - Homo sapiens full open reading frame cDNA clone RZPDo834F116D for gene RPL22, ribosomal protein L22; complete cds, incl. stopcodon.
AK311749 - Homo sapiens cDNA, FLJ92008, Homo sapiens ribosomal protein L22 (RPL22), mRNA.
KJ892031 - Synthetic construct Homo sapiens clone ccsbBroadEn_01425 RPL22 gene, encodes complete protein.
LF357510 - JP 2014500723-A/165013: Polycomb-Associated Non-Coding RNAs.
MA593087 - JP 2018138019-A/165013: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa03010 - Ribosome

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000497965.1, ENST00000497965.2, ENST00000497965.3, ENST00000497965.4, K7ERI7, uc057btf.1, X59357
UCSC ID: ENST00000497965.5
RefSeq Accession: NM_000983

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.