Human Gene IL18 (ENST00000528832.1) Description and Page Index
  Description: Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells. (from UniProt Q14116)
RefSeq Summary (NM_001562): The protein encoded by this gene is a proinflammatory cytokine that augments natural killer cell activity in spleen cells, and stimulates interferon gamma production in T-helper type I cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2011].
Gencode Transcript: ENST00000528832.1
Gencode Gene: ENSG00000150782.12
Transcript (Including UTRs)
   Position: hg38 chr11:112,143,596-112,164,089 Size: 20,494 Total Exon Count: 6 Strand: -
Coding Region
   Position: hg38 chr11:112,143,596-112,155,053 Size: 11,458 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated at UCSC: 2021-01-14 15:32:12

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr11:112,143,596-112,164,089)mRNA (may differ from genome)Protein (193 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Interleukin-18; Short=IL-18; AltName: Full=Iboctadekin; AltName: Full=Interferon gamma-inducing factor; Short=IFN-gamma-inducing factor; AltName: Full=Interleukin-1 gamma; Short=IL-1 gamma; Flags: Precursor;
FUNCTION: Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.
SIMILARITY: Belongs to the IL-1 family.
WEB RESOURCE: Name=Wikipedia; Note=Interleukin-1 entry; URL="";

-  MalaCards Disease Associations
  MalaCards Gene Search: IL18
Diseases sorted by gene-association score: adult-onset still's disease (36), pleural tuberculosis (20), stachybotrys chartarum (18), uremic pruritus (18), latex allergy (13), acute cystitis (12), gillessen-kaesbach-nishimura syndrome (12), necrotizing fasciitis (11), acute kidney failure (11), sapho syndrome (11), autoinflammation with arthritis and dyskeratosis (10), mercury poisoning (10), pulmonary sarcoidosis (10), inflammatory bowel disease (10), hemophagocytic lymphohistiocytosis (9), acute graft versus host disease (9), lymphadenitis (9), melioidosis (9), synovitis (9), spastic cerebral palsy (9), noma (9), schnitzler syndrome (9), melanoma metastasis (9), smallpox (9), familial cold autoinflammatory syndrome (9), hepatorenal syndrome (8), systemic onset juvenile idiopathic arthritis (8), allergic rhinitis (7), relapsing-remitting multiple sclerosis (7), pulmonary tuberculosis (7), t-cell large granular lymphocyte leukemia (7), plasmodium falciparum malaria (7), sarcoidosis 1 (7), salmonellosis (7), cow milk allergy (7), acute pancreatitis (7), cutaneous lupus erythematosus (7), rheumatoid arthritis (7), inflammatory bowel disease 9 (6), rasmussen encephalitis (6), genital herpes (6), cysticercosis (6), arteriosclerosis obliterans (6), tuberculosis (6), brucellosis (5), necrotizing ulcerative gingivitis (5), arthritis (5), fasciitis (5), listeria meningitis (5), systemic lupus erythematosus (5), thrombocytopenic purpura, autoimmune (5), leukomalacia (5), acute kidney tubular necrosis (4), chronic mucocutaneous candidiasis (4), eosinophilic gastritis (4), atopic dermatitis (4), malaria (4), lung sarcoma (4), asthma (4), inflammatory bowel disease 3 (4), obesity (3), autoinflammation, lipodystrophy, and dermatosis syndrome (2), pulmonary fibrosis, idiopathic (2), oral cavity cancer (1), behcet syndrome (1), diabetes mellitus, insulin-dependent (1), rheumatoid arthritis, systemic juvenile (1), diabetes mellitus, noninsulin-dependent (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 71.23 RPKM in Skin - Not Sun Exposed (Suprapubic)
Total median expression: 473.07 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -59.40213-0.279 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR008996 - Cytokine_IL1-like
IPR000975 - Interleukin_1
IPR015529 - Interleukin_18

Pfam Domains:
PF00340 - Interleukin-1 / 18

Protein Data Bank (PDB) 3-D Structure
MuPIT help


- X-ray MuPIT

- X-ray MuPIT
To conserve bandwidth, only the images from the first 3 structures are shown.
4EEE - X-ray MuPIT 4EKX - X-ray MuPIT

ModBase Predicted Comparative 3D Structure on Q14116
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005125 cytokine activity
GO:0005515 protein binding
GO:0045515 interleukin-18 receptor binding

Biological Process:
GO:0000165 MAPK cascade
GO:0001525 angiogenesis
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007267 cell-cell signaling
GO:0008283 cell proliferation
GO:0010469 regulation of receptor activity
GO:0010628 positive regulation of gene expression
GO:0010744 positive regulation of macrophage derived foam cell differentiation
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0019221 cytokine-mediated signaling pathway
GO:0030101 natural killer cell activation
GO:0030155 regulation of cell adhesion
GO:0030431 sleep
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0032148 activation of protein kinase B activity
GO:0032609 interferon-gamma production
GO:0032635 interleukin-6 production
GO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production
GO:0032729 positive regulation of interferon-gamma production
GO:0032740 positive regulation of interleukin-17 production
GO:0032819 positive regulation of natural killer cell proliferation
GO:0034105 positive regulation of tissue remodeling
GO:0035655 interleukin-18-mediated signaling pathway
GO:0035744 T-helper 1 cell cytokine production
GO:0042033 chemokine biosynthetic process
GO:0042088 T-helper 1 type immune response
GO:0042092 type 2 immune response
GO:0042094 interleukin-2 biosynthetic process
GO:0042095 interferon-gamma biosynthetic process
GO:0042104 positive regulation of activated T cell proliferation
GO:0042119 neutrophil activation
GO:0042231 interleukin-13 biosynthetic process
GO:0042253 granulocyte macrophage colony-stimulating factor biosynthetic process
GO:0042267 natural killer cell mediated cytotoxicity
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0042632 cholesterol homeostasis
GO:0045630 positive regulation of T-helper 2 cell differentiation
GO:0045662 negative regulation of myoblast differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050729 positive regulation of inflammatory response
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051142 positive regulation of NK T cell proliferation
GO:0051897 positive regulation of protein kinase B signaling
GO:0070328 triglyceride homeostasis
GO:0071407 cellular response to organic cyclic compound
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:2000556 positive regulation of T-helper 1 cell cytokine production

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005829 cytosol

-  Descriptions from all associated GenBank mRNAs
  KJ897054 - Synthetic construct Homo sapiens clone ccsbBroadEn_06448 IL18 gene, encodes complete protein.
KR710147 - Synthetic construct Homo sapiens clone CCSBHm_00010060 IL18 (IL18) mRNA, encodes complete protein.
E11745 - cDNA encoding polypeptide which induce human interferon-gamma product.
AY266351 - Homo sapiens DELTA3PRO-IL-18 (IL18) mRNA, complete cds; alternatively spliced.
D49950 - Homo sapiens mRNA for interferon-gamma inducing factor(IGIF), complete cds.
BC015863 - Homo sapiens interleukin 18 (interferon-gamma-inducing factor), mRNA (cDNA clone IMAGE:4691511), with apparent retained intron.
BC007007 - Homo sapiens interleukin 18 (interferon-gamma-inducing factor), mRNA (cDNA clone MGC:12321 IMAGE:3686124), complete cds.
BC007461 - Homo sapiens interleukin 18 (interferon-gamma-inducing factor), mRNA (cDNA clone MGC:12320 IMAGE:3681009), complete cds.
AY044641 - Homo sapiens interleukin 18 (IL18) mRNA, complete cds.
AF077611 - Homo sapiens interleukin-18 precursor (IL18) mRNA, complete cds.
AF380360 - Homo sapiens interleukin 18 precursor, mRNA, complete cds.
U90434 - Human interferon-gamma inducing factor precursor (IGIF) mRNA, partial cds.
CR541973 - Homo sapiens full open reading frame cDNA clone RZPDo834F1234D for gene IL18, interleukin 18 (interferon-gamma-inducing factor); complete cds, incl. stopcodon.
E12009 - cDNA encoding human polypeptide which introduce interferon-gamma product in immunocompetent cell.
AB590988 - Synthetic construct DNA, clone: pFN21AE1677, Homo sapiens IL18 gene for interleukin 18, without stop codon, in Flexi system.
CR542001 - Homo sapiens full open reading frame cDNA clone RZPDo834B1235D for gene IL18, interleukin 18 (interferon-gamma-inducing factor); complete cds, without stopcodon.
CU675489 - Synthetic construct Homo sapiens gateway clone IMAGE:100020242 5' read IL18 mRNA.
AK311301 - Homo sapiens cDNA, FLJ18343.
JD095663 - Sequence 76687 from Patent EP1572962.
JD293649 - Sequence 274673 from Patent EP1572962.
JD248501 - Sequence 229525 from Patent EP1572962.
JD539714 - Sequence 520738 from Patent EP1572962.
JD069145 - Sequence 50169 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04060 - Cytokine-cytokine receptor interaction
hsa04621 - NOD-like receptor signaling pathway
hsa04623 - Cytosolic DNA-sensing pathway

BioCarta from NCI Cancer Genome Anatomy Project
h_il18Pathway - IL 18 Signaling Pathway
h_th1th2Pathway - Th1/Th2 Differentiation
h_nkcellsPathway - Ras-Independent pathway in NK cell-mediated cytotoxicity
h_cytokinePathway - Cytokine Network
h_IL12Pathway - IL12 and Stat4 Dependent Signaling Pathway in Th1 Development

Reactome (by CSHL, EBI, and GO)

Protein Q14116 (Reactome details) participates in the following event(s):

R-HSA-8848370 IL18 binds IL18R1
R-HSA-8848392 IL18BP binds IL18
R-HSA-8848395 IL18:IL18R1 binds IL18RAP
R-HSA-448703 Interleukin-1 family precursors are cleaved by caspase-1
R-HSA-9012546 Interleukin-18 signaling
R-HSA-448706 Interleukin-1 processing
R-HSA-6783783 Interleukin-10 signaling
R-HSA-446652 Interleukin-1 family signaling
R-HSA-6785807 Interleukin-4 and 13 signaling
R-HSA-449147 Signaling by Interleukins
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: BC007461, IGIF, IL18_HUMAN, IL1F4, O75599, Q14116, Q6FGY3, uc058hhz.1
UCSC ID: ENST00000528832.1
RefSeq Accession: NM_001562
Protein: Q14116 (aka IL18_HUMAN)
CCDS: CCDS44731.1, CCDS58180.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.