Human Gene DIXDC1 (ENST00000529225.5) Description and Page Index
  Description: Homo sapiens DIX domain containing 1 (DIXDC1), transcript variant 3, mRNA. (from RefSeq NM_001278542)
RefSeq Summary (NM_001278542): The protein encoded by this gene is a positive regulator of the Wnt signaling pathway. The encoded protein is found associated with gamma tubulin at the centrosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013].
Gencode Transcript: ENST00000529225.5
Gencode Gene: ENSG00000150764.14
Transcript (Including UTRs)
   Position: hg38 chr11:111,927,144-111,975,995 Size: 48,852 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg38 chr11:111,929,854-111,974,987 Size: 45,134 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2021-01-14 15:32:12

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr11:111,927,144-111,975,995)mRNA (may differ from genome)Protein (218 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Dixin; AltName: Full=Coiled-coil protein DIX1; Short=Coiled-coil-DIX1; AltName: Full=DIX domain-containing protein 1;
FUNCTION: Positive effector of the Wnt signaling pathway; activates WNT3A signaling via DVL2. Regulates JNK activation by AXIN1 and DVL2.
SUBUNIT: Isoform 1 but not isoform 2 binds filamentous actin. Interacts with the complex composed of DVL2 and Rac. Interacts with AXIN1; competes with MAP3K1. Interacts with MAP3K4 preventing MAP3K4 interaction with AXIN1. Directly interacts (via DIX domain) with DVL2 (via DIX domain). Interacts with gamma-tubulin.
INTERACTION: Q60838:Dvl2 (xeno); NbExp=4; IntAct=EBI-1104700, EBI-641940;
SUBCELLULAR LOCATION: Cytoplasm, cytosol. Note=Colocalizes with gamma-tubulin at the centrosome, both during interphase and mitosis.
SUBCELLULAR LOCATION: Isoform 1: Cell junction, focal adhesion. Note=Associated with actin stress fiber at the filament ends.
SUBCELLULAR LOCATION: Isoform 2: Cytoplasm.
TISSUE SPECIFICITY: Ubiquitously expressed with higher expression in cardiac and skeletal muscles.
DOMAIN: The coiled-coil domain mediates interaction with MAP3K4 and inhibition of AXIN1-mediated JNK activation through MAP3K4.
DOMAIN: The DIX domain mediates interaction with AXIN1 and inhibition of AXIN1-mediated JNK activation through MAP3K1. Mediates interaction with DVL2; this interaction is required for activation of Wnt signaling.
PTM: Phosphorylated on tyrosine and serine residues.
PTM: Polyubiquitinated, leading to its proteasomal degradation. WNT3A signaling increases DIXDC1 protein levels by inhibiting its ubiquitination and subsequent degradation.
SIMILARITY: Belongs to the DIXDC1 family.
SIMILARITY: Contains 1 CH (calponin-homology) domain.
SIMILARITY: Contains 1 DIX domain.
SEQUENCE CAUTION: Sequence=AAH35509.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=AAH64479.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=BAB21826.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAB71039.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -134.40280-0.480 Picture PostScript Text
3' UTR -244.021008-0.242 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001715 - CH-domain
IPR001158 - DIX
IPR015506 - Dsh/Dvl-rel

Pfam Domains:
PF00307 - Calponin homology (CH) domain
PF00778 - DIX domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help

- X-ray MuPIT

ModBase Predicted Comparative 3D Structure on Q155Q3
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003779 actin binding
GO:0005515 protein binding
GO:0019904 protein domain specific binding
GO:0043015 gamma-tubulin binding

Biological Process:
GO:0007275 multicellular organism development
GO:0016055 Wnt signaling pathway
GO:0021795 cerebral cortex cell migration
GO:0021799 cerebral cortex radially oriented cell migration
GO:0021846 cell proliferation in forebrain
GO:0021869 forebrain ventricular zone progenitor cell division
GO:0030177 positive regulation of Wnt signaling pathway
GO:0032956 regulation of actin cytoskeleton organization
GO:0045665 negative regulation of neuron differentiation
GO:0060070 canonical Wnt signaling pathway
GO:0070507 regulation of microtubule cytoskeleton organization
GO:0090263 positive regulation of canonical Wnt signaling pathway

Cellular Component:
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005925 focal adhesion
GO:0030054 cell junction

-  Descriptions from all associated GenBank mRNAs
  BC048294 - Homo sapiens DIX domain containing 1, mRNA (cDNA clone IMAGE:5243423), partial cds.
DQ642016 - Homo sapiens DIX domain containing 1 isoform l (DIXDC1) mRNA, DIXDC1-S allele, complete cds.
BC035509 - Homo sapiens DIX domain containing 1, mRNA (cDNA clone IMAGE:4898802), partial cds.
BC064479 - Homo sapiens DIX domain containing 1, mRNA (cDNA clone IMAGE:5091805), partial cds.
BC128600 - Homo sapiens DIX domain containing 1, mRNA (cDNA clone IMAGE:40132796), complete cds.

-  Other Names for This Gene
  Alternate Gene Symbols: A1A5D8, CCD1, DIXC1_HUMAN, ENST00000529225.1, ENST00000529225.2, ENST00000529225.3, ENST00000529225.4, KIAA1735, NM_001278542, Q155Q3, Q6P2J8, Q6PIK4, Q8IVY4, Q96N69, Q9C0C8, uc001pmj.1, uc001pmj.2, uc001pmj.3, uc001pmj.4
UCSC ID: ENST00000529225.5
RefSeq Accession: NM_001278542
Protein: Q155Q3 (aka DIXC1_HUMAN)
CCDS: CCDS60957.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.