Human Gene AP002884.2 (ENST00000532699.1) Description and Page Index
  Description: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. (from UniProt H3BRW5)
RefSeq Summary (NM_003002): This gene encodes a member of complex II of the respiratory chain, which is responsible for the oxidation of succinate. The encoded protein is one of two integral membrane proteins anchoring the complex to the matrix side of the mitochondrial inner membrane. Mutations in this gene are associated with the formation of tumors, including hereditary paraganglioma. Transmission of disease occurs almost exclusively through the paternal allele, suggesting that this locus may be maternally imprinted. There are pseudogenes for this gene on chromosomes 1, 2, 3, 7, and 18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013].
Gencode Transcript: ENST00000532699.1
Gencode Gene: ENSG00000255292.9
Transcript (Including UTRs)
   Position: hg38 chr11:112,086,903-112,193,561 Size: 106,659 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg38 chr11:112,086,908-112,170,527 Size: 83,620 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsMicroarray ExpressionRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther NamesMethods
Data last updated at UCSC: 2021-01-14 15:32:12

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:112,086,903-112,193,561)mRNA (may differ from genome)Protein (140 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaBioGPSEnsembl
ExonPrimerGeneCardsMGIPubMedUniProtKB

-  Comments and Description Text from UniProtKB
  ID: H3BRW5_HUMAN
DESCRIPTION: SubName: Full=Uncharacterized protein;
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
3' UTR -25.50143-0.178 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007992 - Cyt_b_succ_DH_CybS

Pfam Domains:
PF05328 - CybS, succinate dehydrogenase cytochrome B small subunit

ModBase Predicted Comparative 3D Structure on H3BRW5
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0020037 heme binding
GO:0046872 metal ion binding
GO:0048039 ubiquinone binding
GO:0008177 succinate dehydrogenase (ubiquinone) activity

Biological Process:
GO:0006099 tricarboxylic acid cycle
GO:0006121 mitochondrial electron transport, succinate to ubiquinone
GO:0055114 oxidation-reduction process

Cellular Component:
GO:0005739 mitochondrion
GO:0005740 mitochondrial envelope
GO:0005743 mitochondrial inner membrane
GO:0005749 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AK315300 - Homo sapiens cDNA, FLJ96324, highly similar to Homo sapiens beta-carotene dioxygenase 2 (BCDO2), mRNA.
BC041656 - Homo sapiens beta-carotene oxygenase 2, mRNA (cDNA clone MGC:47563 IMAGE:5175925), complete cds.
BC047934 - Homo sapiens beta-carotene oxygenase 2, mRNA (cDNA clone IMAGE:5199667), with apparent retained intron.
AK091783 - Homo sapiens cDNA FLJ34464 fis, clone HLUNG2003049, weakly similar to Ambystoma tigrinum RPE65 protein mRNA.
AX747181 - Sequence 706 from Patent EP1308459.
AJ290393 - Homo sapiens mRNA for putative b,b-carotene-9',10'-dioxygenase (B-diox-II gene).
CU692016 - Synthetic construct Homo sapiens gateway clone IMAGE:100021150 5' read BCDO2 mRNA.
AF276432 - Homo sapiens putative carotene dioxygenase mRNA, complete cds.
AK027801 - Homo sapiens cDNA FLJ14895 fis, clone PLACE1004646, weakly similar to B.taurus mRNA for retinal pigment epithelial membrane receptor p63.
AK297853 - Homo sapiens cDNA FLJ55991 complete cds, highly similar to Beta,beta-carotene 9',10'-dioxygenase (EC 1.14.99.-).
AB096252 - Homo sapiens LOH11CR1M gene, loss of heterozygosity, 11, chromosomal region 1 gene M product.
LF385377 - JP 2014500723-A/192880: Polycomb-Associated Non-Coding RNAs.
MA620954 - JP 2018138019-A/192880: Polycomb-Associated Non-Coding RNAs.
BC015188 - Homo sapiens succinate dehydrogenase complex, subunit D, integral membrane protein, mRNA (cDNA clone MGC:14593 IMAGE:4279214), complete cds.
BC071755 - Homo sapiens succinate dehydrogenase complex, subunit D, integral membrane protein, mRNA (cDNA clone MGC:88308 IMAGE:4774525), complete cds.
BC015992 - Homo sapiens succinate dehydrogenase complex, subunit D, integral membrane protein, mRNA (cDNA clone MGC:27158 IMAGE:4292983), complete cds.
BC005263 - Homo sapiens succinate dehydrogenase complex, subunit D, integral membrane protein, mRNA (cDNA clone MGC:12303 IMAGE:3930691), complete cds.
BC022350 - Homo sapiens succinate dehydrogenase complex, subunit D, integral membrane protein, mRNA (cDNA clone MGC:23820 IMAGE:4275516), complete cds.
AK075360 - Homo sapiens cDNA PSEC0046 fis, clone NT2RP1001027, highly similar to Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial precursor.
AB006202 - Homo sapiens mRNA for cytochrome b small subunit of complex II, complete cds.
BC012603 - Homo sapiens succinate dehydrogenase complex, subunit D, integral membrane protein, mRNA (cDNA clone MGC:13599 IMAGE:4108104), complete cds.
BC070307 - Homo sapiens succinate dehydrogenase complex, subunit D, integral membrane protein, mRNA (cDNA clone MGC:88307 IMAGE:4277540), complete cds.
BC071756 - Homo sapiens succinate dehydrogenase complex, subunit D, integral membrane protein, mRNA (cDNA clone MGC:88309 IMAGE:6450992), complete cds.
BC009574 - Homo sapiens succinate dehydrogenase complex, subunit D, integral membrane protein, mRNA (cDNA clone MGC:14562 IMAGE:4063808), complete cds.
JD176201 - Sequence 157225 from Patent EP1572962.
CR456932 - Homo sapiens full open reading frame cDNA clone RZPDo834C0116D for gene SDHD, succinate dehydrogenase complex, subunit D, integral membrane protein; complete cds, incl. stopcodon.
KU178325 - Homo sapiens succinate dehydrogenase complex subunit D integral membrane protein isoform 1 (SDHD) mRNA, partial cds.
KU178326 - Homo sapiens succinate dehydrogenase complex subunit D integral membrane protein isoform 2 (SDHD) mRNA, complete cds, alternatively spliced.
BT007238 - Homo sapiens succinate dehydrogenase complex, subunit D, integral membrane protein mRNA, complete cds.
DQ892701 - Synthetic construct Homo sapiens clone IMAGE:100005331; FLH263578.01X; RZPDo839B1078D succinate dehydrogenase complex, subunit D, integral membrane protein (SDHD) gene, encodes complete protein.
DQ896292 - Synthetic construct Homo sapiens clone IMAGE:100010752; FLH192994.01L; RZPDo839B0868D succinate dehydrogenase complex, subunit D, integral membrane protein (SDHD) gene, encodes complete protein.
CU675071 - Synthetic construct Homo sapiens gateway clone IMAGE:100016718 5' read SDHD mRNA.
KJ892121 - Synthetic construct Homo sapiens clone ccsbBroadEn_01515 SDHD gene, encodes complete protein.
KJ897535 - Synthetic construct Homo sapiens clone ccsbBroadEn_06929 SDHD gene, encodes complete protein.
KR710196 - Synthetic construct Homo sapiens clone CCSBHm_00010294 SDHD (SDHD) mRNA, encodes complete protein.
KR710197 - Synthetic construct Homo sapiens clone CCSBHm_00010307 SDHD (SDHD) mRNA, encodes complete protein.
KR710198 - Synthetic construct Homo sapiens clone CCSBHm_00010315 SDHD (SDHD) mRNA, encodes complete protein.
KR710199 - Synthetic construct Homo sapiens clone CCSBHm_00010327 SDHD (SDHD) mRNA, encodes complete protein.
BC029506 - Homo sapiens testis expressed 12, mRNA (cDNA clone MGC:33672 IMAGE:5298531), complete cds.
AF285600 - Homo sapiens testis protein TEX12 (TEX12) mRNA, complete cds.
HQ447961 - Synthetic construct Homo sapiens clone IMAGE:100071323; CCSB002160_02 testis expressed 12 (TEX12) gene, encodes complete protein.
KJ899239 - Synthetic construct Homo sapiens clone ccsbBroadEn_08633 TEX12 gene, encodes complete protein.
CU688674 - Synthetic construct Homo sapiens gateway clone IMAGE:100018518 5' read TEX12 mRNA.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa00020 - Citrate cycle (TCA cycle)
hsa00190 - Oxidative phosphorylation
hsa01100 - Metabolic pathways
hsa05010 - Alzheimer's disease
hsa05012 - Parkinson's disease
hsa05016 - Huntington's disease

-  Other Names for This Gene
  Alternate Gene Symbols: BC012603, H3BRW5, H3BRW5_HUMAN, uc058hhu.1
UCSC ID: ENST00000532699.1
RefSeq Accession: NM_003002
Protein: H3BRW5

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.