Human Gene AP002884.2 (ENST00000532699.1) Description and Page Index
Description: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. (from UniProt H3BRW5) RefSeq Summary (NM_003002): This gene encodes a member of complex II of the respiratory chain, which is responsible for the oxidation of succinate. The encoded protein is one of two integral membrane proteins anchoring the complex to the matrix side of the mitochondrial inner membrane. Mutations in this gene are associated with the formation of tumors, including hereditary paraganglioma. Transmission of disease occurs almost exclusively through the paternal allele, suggesting that this locus may be maternally imprinted. There are pseudogenes for this gene on chromosomes 1, 2, 3, 7, and 18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013]. Gencode Transcript: ENST00000532699.1 Gencode Gene: ENSG00000255292.9 Transcript (Including UTRs) Position: hg38 chr11:112,086,903-112,193,561 Size: 106,659 Total Exon Count: 6 Strand: + Coding Region Position: hg38 chr11:112,086,908-112,170,527 Size: 83,620 Coding Exon Count: 4
ID:H3BRW5_HUMAN DESCRIPTION: SubName: Full=Uncharacterized protein; CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.
Microarray Expression Data
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The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF05328 - CybS, succinate dehydrogenase cytochrome B small subunit
ModBase Predicted Comparative 3D Structure on H3BRW5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.