Human Gene RRAS2 (ENST00000534746.5) Description and Page Index
Description: It is a plasma membrane-associated GTP-binding protein with GTPase activity. Might transduce growth inhibitory signals across the cell membrane, exerting its effect through an effector shared with the Ras proteins but in an antagonistic fashion. (from UniProt P62070) RefSeq Summary (NM_001177314): This gene encodes a member of the R-Ras subfamily of Ras-like small GTPases. The encoded protein associates with the plasma membrane and may function as a signal transducer. This protein may play an important role in activating signal transduction pathways that control cell proliferation. Mutations in this gene are associated with the growth of certain tumors. Pseudogenes of this gene are found on chromosomes 1 and 2. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]. Gencode Transcript: ENST00000534746.5 Gencode Gene: ENSG00000133818.14 Transcript (Including UTRs) Position: hg38 chr11:14,278,939-14,354,500 Size: 75,562 Total Exon Count: 6 Strand: - Coding Region Position: hg38 chr11:14,279,337-14,294,827 Size: 15,491 Coding Exon Count: 4
ID:RRAS2_HUMAN DESCRIPTION: RecName: Full=Ras-related protein R-Ras2; AltName: Full=Ras-like protein TC21; AltName: Full=Teratocarcinoma oncogene; Flags: Precursor; FUNCTION: It is a plasma membrane-associated GTP-binding protein with GTPase activity. Might transduce growth inhibitory signals across the cell membrane, exerting its effect through an effector shared with the Ras proteins but in an antagonistic fashion. INTERACTION: P10398:ARAF; NbExp=3; IntAct=EBI-491037, EBI-365961; SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side (By similarity). Note=Inner surface of plasma membrane possibly with attachment requiring acylation of the C-terminal cysteine (By similarity with RAS). TISSUE SPECIFICITY: Ubiquitously present in all tissues examined, with the highest levels in heart, placenta, and skeletal muscle. Moderate levels in lung and liver; low levels in brain, kidney, and pancreas. PTM: May be post-translationally modified by both palmitoylation and polyisoprenylation. DISEASE: Defects in RRAS2 are a cause of susceptibility to ovarian cancer (OC) [MIM:167000]. The term ovarian cancer defines common malignancies originating from ovarian tissue. Although many histologic types of ovarian tumors have been described, epithelial ovarian carcinoma is the most common form. Ovarian cancers are often asymptomatic and the recognized signs and symptoms, even of late-stage disease, are vague. Consequently, most patients are diagnosed with advanced disease. SIMILARITY: Belongs to the small GTPase superfamily. Ras family. SEQUENCE CAUTION: Sequence=AAA36545.1; Type=Frameshift; Positions=4, 8, 12; Sequence=AAM12638.1; Type=Frameshift; Positions=4, 8, 12;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P62070
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.