Human Gene KLRC2 (ENST00000536833.6)
  Description: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. (from UniProt F5H518)
RefSeq Summary (NM_002260): Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The group, designated KLRC (NKG2) are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The KLRC (NKG2) gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. KLRC2 alternative splice variants have been described but their full-length nature has not been determined. [provided by RefSeq, Jul 2008].
Gencode Transcript: ENST00000536833.6
Gencode Gene: ENSG00000205809.9
Transcript (Including UTRs)
   Position: hg38 chr12:10,430,980-10,442,300 Size: 11,321 Total Exon Count: 7 Strand: -
Coding Region
   Position: hg38 chr12:10,431,117-10,437,711 Size: 6,595 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated at UCSC: 2021-01-14 15:32:12

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr12:10,430,980-10,442,300)mRNA (may differ from genome)Protein (172 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS

-  Comments and Description Text from UniProtKB
  ID: F5H518_HUMAN
DESCRIPTION: SubName: Full=NKG2-C type II integral membrane protein;
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  MalaCards Disease Associations
  MalaCards Gene Search: KLRC2
Diseases sorted by gene-association score: trachoma (6)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 2.05 RPKM in Brain - Hypothalamus
Total median expression: 20.38 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -17.00115-0.148 Picture PostScript Text
3' UTR -21.30137-0.155 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001304 - C-type_lectin
IPR016186 - C-type_lectin-like
IPR016187 - C-type_lectin_fold

Pfam Domains:
PF00059 - Lectin C-type domain

ModBase Predicted Comparative 3D Structure on F5H518
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
 Protein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0030246 carbohydrate binding

Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane

-  Descriptions from all associated GenBank mRNAs
  AF461157 - Homo sapiens NKG2E mRNA, complete cds.
AF350017 - Homo sapiens NKG2E (NKG2E) mRNA, NKG2E03 allele, complete cds.
AK295525 - Homo sapiens cDNA FLJ60557 complete cds, highly similar to NKG2-C type II integral membrane protein.
BC106069 - Homo sapiens killer cell lectin-like receptor subfamily C, member 2, mRNA (cDNA clone IMAGE:5104202), partial cds.
X54869 - Human mRNA for NKG2-C gene.
JD081200 - Sequence 62224 from Patent EP1572962.
BC112039 - Homo sapiens killer cell lectin-like receptor subfamily C, member 2, mRNA (cDNA clone MGC:138244 IMAGE:8327507), complete cds.
BC093644 - Homo sapiens killer cell lectin-like receptor subfamily C, member 2, mRNA (cDNA clone MGC:120679 IMAGE:7939489), complete cds.
Y13055 - Homo sapiens mRNA for NKG2-CII activating NK receptor.
AF260134 - Homo sapiens NK cell receptor C (NKG2-C) mRNA, NKG2-C*02 allele, complete cds.
KJ897101 - Synthetic construct Homo sapiens clone ccsbBroadEn_06495 KLRC2 gene, encodes complete protein.
AK310992 - Homo sapiens cDNA, FLJ18034.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04612 - Antigen processing and presentation
hsa04650 - Natural killer cell mediated cytotoxicity

BioCarta from NCI Cancer Genome Anatomy Project
h_nkcellsPathway - Ras-Independent pathway in NK cell-mediated cytotoxicity

-  Other Names for This Gene
  Alternate Gene Symbols: BC106069, ENST00000536833.1, ENST00000536833.2, ENST00000536833.3, ENST00000536833.4, ENST00000536833.5, F5H518, F5H518_HUMAN, uc058leg.1
UCSC ID: ENST00000536833.6
RefSeq Accession: NM_002260
Protein: F5H518

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.