Human Gene TIMM8B (ENST00000541231.1) Description and Page Index
  Description: translocase of inner mitochondrial membrane 8 homolog B (from HGNC TIMM8B)
RefSeq Summary (NM_012459): This gene encodes a member of a well-conserved family of proteins with similarity to yeast Tim mitochondrial import proteins. This gene is encoded by a nuclear gene and is transported into the intermembrane space of the mitochondrion. When formed into complexes, these proteins guide membrane-spanning proteins across the mitochondrial intermembrane space before they are added into the mitochondrial inner membrane. This gene is adjacent to succinate dehydrogenase, subunit D (SDHD), in which mutations have been found in affected members of families with hereditary paraganglioma.[provided by RefSeq, Aug 2009].
Gencode Transcript: ENST00000541231.1
Gencode Gene: ENSG00000150779.12
Transcript (Including UTRs)
   Position: hg38 chr11:112,084,817-112,086,798 Size: 1,982 Total Exon Count: 2 Strand: -
Coding Region
   Position: hg38 chr11:112,085,295-112,086,768 Size: 1,474 Coding Exon Count: 2 

Page IndexSequence and LinksCTDRNA-Seq ExpressionMicroarray ExpressionRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2021-01-14 15:32:12

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:112,084,817-112,086,798)mRNA (may differ from genome)Protein (98 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblExonPrimerGeneCardsHGNCLynx
MGIPubMedUniProtKB

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 16.73 RPKM in Heart - Left Ventricle
Total median expression: 384.86 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -6.5030-0.217 Picture PostScript Text
3' UTR -115.00478-0.241 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR004217 - Tim8/9/10/13_Znf-like

Pfam Domains:
PF02953 - Tim10/DDP family zinc finger

ModBase Predicted Comparative 3D Structure on G3XAN8
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologGenome BrowserNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsemblEnsembl  
Protein SequenceProtein Sequence Protein Sequence  
AlignmentAlignment Alignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0046872 metal ion binding

Biological Process:
GO:0015031 protein transport

Cellular Component:
GO:0005739 mitochondrion


-  Descriptions from all associated GenBank mRNAs
  KJ902435 - Synthetic construct Homo sapiens clone ccsbBroadEn_11829 TIMM8B gene, encodes complete protein.
AF150087 - Homo sapiens small zinc finger-like protein (DDP2) mRNA, complete cds.
BC105986 - Homo sapiens translocase of inner mitochondrial membrane 8 homolog B (yeast), mRNA (cDNA clone MGC:102866 IMAGE:4510312), complete cds.
BC106067 - Homo sapiens translocase of inner mitochondrial membrane 8 homolog B (yeast), mRNA (cDNA clone MGC:117373 IMAGE:4708781), complete cds.
BC000711 - Homo sapiens translocase of inner mitochondrial membrane 8 homolog B (yeast), mRNA (cDNA clone MGC:1102 IMAGE:2823930), complete cds.
AK025397 - Homo sapiens cDNA: FLJ21744 fis, clone COLF4965.
AF165967 - Homo sapiens DDP-like protein mRNA, complete cds.
JD385950 - Sequence 366974 from Patent EP1572962.
JD508251 - Sequence 489275 from Patent EP1572962.
AF152350 - Homo sapiens TIMM8b mRNA, complete cds.
AK312169 - Homo sapiens cDNA, FLJ92455, Homo sapiens translocase of inner mitochondrial membrane 8 homologB (yeast) (TIMM8B), mRNA.

-  Other Names for This Gene
  Alternate Gene Symbols: BC105986, G3XAN8, G3XAN8_HUMAN, hCG_39462, uc001pmx.1, uc001pmx.2, uc001pmx.3, uc001pmx.4, uc001pmx.5
UCSC ID: ENST00000541231.1
RefSeq Accession: NM_012459
Protein: G3XAN8 CCDS: CCDS8357.2

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.