Human Gene TIMM8B (ENST00000541231.1) Description and Page Index
Description: translocase of inner mitochondrial membrane 8 homolog B (from HGNC TIMM8B) RefSeq Summary (NM_012459): This gene encodes a member of a well-conserved family of proteins with similarity to yeast Tim mitochondrial import proteins. This gene is encoded by a nuclear gene and is transported into the intermembrane space of the mitochondrion. When formed into complexes, these proteins guide membrane-spanning proteins across the mitochondrial intermembrane space before they are added into the mitochondrial inner membrane. This gene is adjacent to succinate dehydrogenase, subunit D (SDHD), in which mutations have been found in affected members of families with hereditary paraganglioma.[provided by RefSeq, Aug 2009]. Gencode Transcript: ENST00000541231.1 Gencode Gene: ENSG00000150779.12 Transcript (Including UTRs) Position: hg38 chr11:112,084,817-112,086,798 Size: 1,982 Total Exon Count: 2 Strand: - Coding Region Position: hg38 chr11:112,085,295-112,086,768 Size: 1,474 Coding Exon Count: 2
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF02953 - Tim10/DDP family zinc finger
ModBase Predicted Comparative 3D Structure on G3XAN8
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.