Human Gene AK2 (ENST00000548033.5) Description and Page Index
Description: Homo sapiens adenylate kinase 2 (AK2), transcript variant 7, mRNA. (from RefSeq NM_001319142) RefSeq Summary (NM_001319142): Adenylate kinases are involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. Three isozymes of adenylate kinase, namely 1, 2, and 3, have been identified in vertebrates; this gene encodes isozyme 2. Expression of these isozymes is tissue-specific and developmentally regulated. Isozyme 2 is localized in the mitochondrial intermembrane space and may play a role in apoptosis. Mutations in this gene are the cause of reticular dysgenesis. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1 and 2.[provided by RefSeq, Nov 2010]. Gencode Transcript: ENST00000548033.5 Gencode Gene: ENSG00000004455.17 Transcript (Including UTRs) Position: hg38 chr1:33,010,478-33,036,840 Size: 26,363 Total Exon Count: 6 Strand: - Coding Region Position: hg38 chr1:33,010,829-33,036,828 Size: 26,000 Coding Exon Count: 6
ID:F8VY04_HUMAN DESCRIPTION: SubName: Full=Adenylate kinase 2, mitochondrial; SIMILARITY: Belongs to the adenylate kinase family. CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00406 - Adenylate kinase PF05191 - Adenylate kinase, active site lid
ModBase Predicted Comparative 3D Structure on F8VY04
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.