ID:DHRS4_HUMAN DESCRIPTION: RecName: Full=Dehydrogenase/reductase SDR family member 4; EC=18.104.22.168; AltName: Full=NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenase; Short=CR; Short=PHCR; AltName: Full=NADPH-dependent retinol dehydrogenase/reductase; Short=NRDR; Short=humNRDR; AltName: Full=Peroxisomal short-chain alcohol dehydrogenase; Short=PSCD; AltName: Full=SCAD-SRL; AltName: Full=Short-chain dehydrogenase/reductase family member 4; FUNCTION: Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co- factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity). CATALYTIC ACTIVITY: R-CHOH-R' + NADP(+) = R-CO-R' + NADPH. SUBUNIT: Homotetramer (By similarity). SUBCELLULAR LOCATION: Peroxisome. Note=Isoform 1 is peroxisomal, while isoform 4 is not. SUBCELLULAR LOCATION: Isoform 7: Nucleus. TISSUE SPECIFICITY: Isoform 1 is predominantly expressed in normal cervix (at protein level). Isoform 4 is expressed in some neoplastic cervical tissues, but not in normal cervix (at protein level). Isoform 5 and isoform 6 are expressed in a few neoplastic cervical tissues. MISCELLANEOUS: Inhibited by kaempferol, quercetin, genistein and myristic acid (By similarity). SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR) family. SEQUENCE CAUTION: Sequence=AAD02292.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAL61824.2; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB18775.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAG37057.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9BTZ2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.