Human Gene DHRS4 (ENST00000558263.5) Description and Page Index
  Description: Homo sapiens dehydrogenase/reductase 4 (DHRS4), transcript variant 2, mRNA. (from RefSeq NM_001282987)
Gencode Transcript: ENST00000558263.5
Gencode Gene: ENSG00000157326.19
Transcript (Including UTRs)
   Position: hg38 chr14:23,953,734-23,969,274 Size: 15,541 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg38 chr14:23,953,789-23,968,807 Size: 15,019 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathways
Other NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr14:23,953,734-23,969,274)mRNA (may differ from genome)Protein (188 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
HPRDLynxMGIneXtProtOMIMPubMed
ReactomeStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: DHRS4_HUMAN
DESCRIPTION: RecName: Full=Dehydrogenase/reductase SDR family member 4; EC=1.1.1.184; AltName: Full=NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenase; Short=CR; Short=PHCR; AltName: Full=NADPH-dependent retinol dehydrogenase/reductase; Short=NRDR; Short=humNRDR; AltName: Full=Peroxisomal short-chain alcohol dehydrogenase; Short=PSCD; AltName: Full=SCAD-SRL; AltName: Full=Short-chain dehydrogenase/reductase family member 4;
FUNCTION: Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co- factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity).
CATALYTIC ACTIVITY: R-CHOH-R' + NADP(+) = R-CO-R' + NADPH.
SUBUNIT: Homotetramer (By similarity).
SUBCELLULAR LOCATION: Peroxisome. Note=Isoform 1 is peroxisomal, while isoform 4 is not.
SUBCELLULAR LOCATION: Isoform 7: Nucleus.
TISSUE SPECIFICITY: Isoform 1 is predominantly expressed in normal cervix (at protein level). Isoform 4 is expressed in some neoplastic cervical tissues, but not in normal cervix (at protein level). Isoform 5 and isoform 6 are expressed in a few neoplastic cervical tissues.
MISCELLANEOUS: Inhibited by kaempferol, quercetin, genistein and myristic acid (By similarity).
SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
SEQUENCE CAUTION: Sequence=AAD02292.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAL61824.2; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB18775.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAG37057.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 21.61 RPKM in Liver
Total median expression: 491.71 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -13.1055-0.238 Picture PostScript Text
3' UTR -176.00467-0.377 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002198 - DH_sc/Rdtase_SDR
IPR002347 - Glc/ribitol_DH
IPR016040 - NAD(P)-bd_dom
IPR020904 - Sc_DH/Rdtase_CS

Protein Data Bank (PDB) 3-D Structure
MuPIT help

3O4R
- X-ray MuPIT


ModBase Predicted Comparative 3D Structure on Q9BTZ2
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000253 3-keto sterol reductase activity
GO:0004090 carbonyl reductase (NADPH) activity
GO:0005102 receptor binding
GO:0016491 oxidoreductase activity
GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
GO:0018455 alcohol dehydrogenase [NAD(P)+] activity
GO:0052650 NADP-retinol dehydrogenase activity

Biological Process:
GO:0006066 alcohol metabolic process
GO:0006625 protein targeting to peroxisome
GO:0008202 steroid metabolic process
GO:0042180 cellular ketone metabolic process
GO:0042572 retinol metabolic process
GO:0051262 protein tetramerization
GO:0055114 oxidation-reduction process

Cellular Component:
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005777 peroxisome
GO:0005778 peroxisomal membrane
GO:0005782 peroxisomal matrix
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol


-  Descriptions from all associated GenBank mRNAs
  AY616182 - Homo sapiens NADP(H)-dependent retinol dehydrogenase A2 isoform (DHRS4) mRNA, complete cds.
DQ344810 - Homo sapiens NADP(H)-dependent retinol dehydrogenase/reductase short isoform (DHRS4) mRNA, complete cds.
AY358638 - Homo sapiens clone DNA35672 SCAD-SRL (UNQ851) mRNA, complete cds.
AF064256 - Homo sapiens Hep27-like protein mRNA, complete cds.
AF044127 - Homo sapiens peroxisomal short-chain alcohol dehydrogenase (SCAD-SRL) mRNA, complete cds.
AK001870 - Homo sapiens cDNA FLJ11008 fis, clone PLACE1003100, moderately similar to HEP27 PROTEIN.
AB045131 - Homo sapiens humNRDR mRNA for NADPH-dependent retinol dehydrogenase/reductase, complete cds.
AY071856 - Homo sapiens NADP-dependent retinol dehydrogenase short isoform mRNA, complete cds.
BC003019 - Homo sapiens dehydrogenase/reductase (SDR family) member 4, mRNA (cDNA clone MGC:4052 IMAGE:2822884), complete cds.
AK308436 - Homo sapiens cDNA, FLJ98384.
DQ325464 - Homo sapiens NADP(H)-dependent retinol dehydrogenase/reductase B1 isoform (DHRS4) mRNA, complete cds, alternatively spliced.
AK314448 - Homo sapiens cDNA, FLJ95247, highly similar to Homo sapiens dehydrogenase/reductase (SDR family) member 4 (DHRS4), mRNA.
KJ904664 - Synthetic construct Homo sapiens clone ccsbBroadEn_14058 DHRS4-like gene, encodes complete protein.
AK301201 - Homo sapiens cDNA FLJ54180 complete cds, highly similar to Homo sapiens dehydrogenase/reductase (SDR family) member 4 (DHRS4), mRNA.
DL491728 - Novel nucleic acids.
DL490308 - Novel nucleic acids.
DQ338571 - Homo sapiens NADP(H)-dependent retinol dehydrogenase/reductase B2 isoform (DHRS4) mRNA, partial cds, alternatively spliced.
AK021587 - Homo sapiens cDNA FLJ11525 fis, clone HEMBA1002552.
JD424913 - Sequence 405937 from Patent EP1572962.
JD098526 - Sequence 79550 from Patent EP1572962.
JD294480 - Sequence 275504 from Patent EP1572962.
JD113247 - Sequence 94271 from Patent EP1572962.
JD099644 - Sequence 80668 from Patent EP1572962.
JD071377 - Sequence 52401 from Patent EP1572962.
JD416114 - Sequence 397138 from Patent EP1572962.
JD253629 - Sequence 234653 from Patent EP1572962.
JD050550 - Sequence 31574 from Patent EP1572962.
JD216314 - Sequence 197338 from Patent EP1572962.
JD312958 - Sequence 293982 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa00830 - Retinol metabolism
hsa01100 - Metabolic pathways
hsa04146 - Peroxisome

Reactome (by CSHL, EBI, and GO)

Protein Q9BTZ2 (Reactome details) participates in the following event(s):

R-HSA-9033233 PEX5S,L binds cargo proteins containing PTS1
R-HSA-5419165 RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL
R-HSA-9033236 PEX5S,L:Cargo binds PEX13:PEX14 of PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Complex)
R-HSA-9033241 Peroxisomal protein import
R-HSA-5365859 RA biosynthesis pathway
R-HSA-392499 Metabolism of proteins
R-HSA-5362517 Signaling by Retinoic Acid
R-HSA-9006931 Signaling by Nuclear Receptors
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: B2RB10, B7WNS9, D3YTB8, DHRS4_HUMAN, NM_001282987, O95162, Q20CR0, Q2LC19, Q2LE81, Q58IU4, Q6E0Y1, Q6UWU3, Q71UQ6, Q8TD03, Q9BTZ2, Q9H3N5, Q9NV08, uc032avu.1, uc032avu.2, UNQ851/PRO1800
UCSC ID: uc032avu.2
RefSeq Accession: NM_001282987
Protein: Q9BTZ2 (aka DHRS4_HUMAN or DHS4_HUMAN)
CCDS: CCDS61408.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.