Human Gene BCAS3 (ENST00000588462.5) Description and Page Index
Description: Homo sapiens BCAS3 microtubule associated cell migration factor (BCAS3), transcript variant 4, mRNA. (from RefSeq NM_001330413)
Gencode Transcript: ENST00000588462.5
Gencode Gene: ENSG00000141376.23
Transcript (Including UTRs)
Position: hg38 chr17:60,679,458-61,392,831 Size: 713,374 Total Exon Count: 25 Strand: +
Position: hg38 chr17:60,679,458-61,392,125 Size: 712,668 Coding Exon Count: 25
Data last updated at UCSC: 2021-01-14 15:32:12
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Breast carcinoma-amplified sequence 3; AltName: Full=GAOB1;
INTERACTION: P08670:VIM; NbExp=3; IntAct=EBI-6083685, EBI-353844; SUBCELLULAR LOCATION: Nucleus (Potential). TISSUE SPECIFICITY: Expressed in stomach, liver, lung, kidney, prostate, testis, thyroid gland, adrenal gland, brain, heart, skeletal muscle, colon, spleen, small intestine, placenta, blood leukocyte and mammary epithelial cells. Overexpressed in most breast cancer cell lines. DEVELOPMENTAL STAGE: Fetal. DISEASE: Note=A chromosomal aberration involving BCAS3 has been found in some breast carcinoma cell lines. Translocation t(17;20)(q23;q13) with BCAS4. SIMILARITY: Belongs to the WD repeat BCAS3 family. SIMILARITY: Contains 3 WD repeats. SEQUENCE CAUTION: Sequence=AAF70324.1; Type=Frameshift; Positions=693; Sequence=AAL99634.1; Type=Erroneous initiation; Sequence=BAA90966.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB14078.1; Type=Erroneous initiation; Note=Translation N-terminally extended; WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/BCAS3ID766.html";
MalaCards Disease Associations
Comparative Toxicogenomics Database (CTD)
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR022175 - BCAS3
IPR015943 - WD40/YVTN_repeat-like_dom
IPR001680 - WD40_repeat
Pfam Domains: PF12490 - Breast carcinoma amplified sequence 3
PF00400 - WD domain, G-beta repeat
ModBase Predicted Comparative 3D Structure on Q9H6U6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
AK304791 - Homo sapiens cDNA FLJ58237 complete cds, highly similar to Breast carcinoma amplified sequence 3. AK225757 - Homo sapiens mRNA for Splice isoform 3 of Q9H6U6 variant, clone: FCC135C12. BC017390 - Homo sapiens breast carcinoma amplified sequence 3, mRNA (cDNA clone IMAGE:4108577), partial cds. AK314744 - Homo sapiens cDNA, FLJ95607, highly similar to Homo sapiens breast carcinoma amplified sequence 3 (BCAS3), mRNA. AF361219 - Homo sapiens breast carcinoma amplified sequence 3 (BCAS3) mRNA, complete cds. BC117275 - Homo sapiens breast carcinoma amplified sequence 3, mRNA (cDNA clone MGC:150884 IMAGE:40125826), complete cds. BC143386 - Homo sapiens breast carcinoma amplified sequence 3, mRNA (cDNA clone MGC:176909 IMAGE:9051892), complete cds. BC143387 - Homo sapiens breast carcinoma amplified sequence 3, mRNA (cDNA clone MGC:176910 IMAGE:9051893), complete cds. AK025510 - Homo sapiens cDNA: FLJ21857 fis, clone HEP02294. AK022526 - Homo sapiens cDNA FLJ12464 fis, clone NT2RM1000780. AJ518105 - Homo sapiens partial mRNA for Maab2 protein. AJ518836 - Homo sapiens partial mRNA for Maab3 protein. AK023054 - Homo sapiens cDNA FLJ12992 fis, clone NT2RP3000149. BC001250 - Homo sapiens breast carcinoma amplified sequence 3, mRNA (cDNA clone IMAGE:3458571), partial cds. AL831895 - Homo sapiens mRNA; cDNA DKFZp547L188 (from clone DKFZp547L188). AK000135 - Homo sapiens cDNA FLJ20128 fis, clone COL06181. AF260268 - Homo sapiens GAOB1 mRNA, complete cds. CU674626 - Synthetic construct Homo sapiens gateway clone IMAGE:100017160 5' read BCAS3 mRNA. KJ902698 - Synthetic construct Homo sapiens clone ccsbBroadEn_12092 BCAS3 gene, encodes complete protein. BC033220 - Homo sapiens breast carcinoma amplified sequence 3, mRNA (cDNA clone IMAGE:5018525), with apparent retained intron. BC036280 - Homo sapiens breast carcinoma amplified sequence 3, mRNA (cDNA clone IMAGE:3917955). BC013841 - Homo sapiens breast carcinoma amplified sequence 3, mRNA (cDNA clone IMAGE:3923751). BC029983 - Homo sapiens breast carcinoma amplified sequence 3, mRNA (cDNA clone IMAGE:3917933). JD399344 - Sequence 380368 from Patent EP1572962. AF361221 - Homo sapiens breast carcinoma amplified sequence 4/3 fusion protein (BCAS4/BCAS3 fusion) mRNA, complete cds. AK125409 - Homo sapiens cDNA FLJ43420 fis, clone OCBBF2026645. AJ511332 - Homo sapiens partial mRNA for Maab1 protein. BX648103 - Homo sapiens mRNA; cDNA DKFZp686O1527 (from clone DKFZp686O1527). JD163680 - Sequence 144704 from Patent EP1572962. JD273552 - Sequence 254576 from Patent EP1572962. JD393930 - Sequence 374954 from Patent EP1572962. JD272191 - Sequence 253215 from Patent EP1572962. JD153968 - Sequence 134992 from Patent EP1572962. JD495292 - Sequence 476316 from Patent EP1572962. JD439896 - Sequence 420920 from Patent EP1572962. JD136566 - Sequence 117590 from Patent EP1572962. JD117871 - Sequence 98895 from Patent EP1572962. JD545712 - Sequence 526736 from Patent EP1572962. JD141697 - Sequence 122721 from Patent EP1572962. JD382657 - Sequence 363681 from Patent EP1572962. JD177892 - Sequence 158916 from Patent EP1572962. JD378184 - Sequence 359208 from Patent EP1572962. JD396906 - Sequence 377930 from Patent EP1572962.
Other Names for This Gene
Alternate Gene Symbols: BCAS3_HUMAN, ENST00000588462.1, ENST00000588462.2, ENST00000588462.3, ENST00000588462.4, NM_001330413, Q17RM0, Q6KF21, Q8IXI6, Q8NDR8, Q8TDL9, Q8TDM1, Q8WY55, Q9BVF0, Q9H6U6, Q9H957, Q9H9Y9, Q9NXP4, uc060iig.1 UCSC ID: ENST00000588462.5 RefSeq Accession: NM_001330413
(aka BCAS3_HUMAN or BCS3_HUMAN) Q9H6U6
CCDS: CCDS11626.1, CCDS45749.1, CCDS82176.1, CCDS82178.1
Methods, Credits, and Use Restrictions
for details on how this gene model was made and data restrictions if any.