Human Gene RAB4B-EGLN2 (ENST00000594136.2) Description and Page Index
  Description: Homo sapiens RAB4B-EGLN2 readthrough (NMD candidate) (RAB4B-EGLN2), long non-coding RNA. (from RefSeq NR_037791)
RefSeq Summary (NR_037791): This locus represents naturally occurring read-through transcription between the neighboring RAB4B (RAB4B, member RAS oncogene family) and EGLN2 (egl nine homolog 2) genes on chromosome 19. The read-through transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is thus unlikely to produce a protein product. [provided by RefSeq, Feb 2011]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AK291385.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## readthrough transcript :: includes exons from GeneID 53916, 112398 ##RefSeq-Attributes-END##
Gencode Transcript: ENST00000594136.2
Gencode Gene: ENSG00000171570.11
Transcript (Including UTRs)
   Position: hg38 chr19:40,778,271-40,808,418 Size: 30,148 Total Exon Count: 12 Strand: +
Coding Region
   Position: hg38 chr19:40,778,376-40,786,963 Size: 8,588 Coding Exon Count: 7 

Page IndexSequence and LinksMicroarray ExpressionRNA StructureOther SpeciesmRNA Descriptions
Other NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr19:40,778,271-40,808,418)mRNA (may differ from genome)Protein (213 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaBioGPSCGAP
EnsemblEntrez GeneExonPrimerGeneCardsHGNCLynx
MGIPubMedStanford SOURCEUniProtKB

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -54.60105-0.520 Picture PostScript Text
3' UTR -933.802027-0.461 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Descriptions from all associated GenBank mRNAs
  AK302147 - Homo sapiens cDNA FLJ60193 complete cds, highly similar to Melanoma-derived growth regulatory protein precursor.
AF087861 - Homo sapiens rab4b mRNA, complete cds.
BC046927 - Homo sapiens RAB4B, member RAS oncogene family, mRNA (cDNA clone MGC:52123 IMAGE:5805921), complete cds.
AK291385 - Homo sapiens cDNA FLJ78649 complete cds, highly similar to Homo sapiens egl nine homolog 2 (C. elegans) (EGLN2), transcript variant 1, mRNA.
AF165522 - Homo sapiens ras-related GTP-binding protein 4b (RAB4B) mRNA, complete cds.
BC033081 - Homo sapiens RAB4B, member RAS oncogene family, mRNA (cDNA clone MGC:45640 IMAGE:5456088), complete cds.
CU692346 - Synthetic construct Homo sapiens gateway clone IMAGE:100022367 5' read RAB4B mRNA.
EU832708 - Synthetic construct Homo sapiens clone HAIB:100067737; DKFZo004D0432 RAB4B, member RAS oncogene family protein (RAB4B) gene, encodes complete protein.
HQ447628 - Synthetic construct Homo sapiens clone IMAGE:100070974; CCSB013585_01 RAB4B, member RAS oncogene family (RAB4B) gene, encodes complete protein.
EU832633 - Synthetic construct Homo sapiens clone HAIB:100067662; DKFZo008D0431 RAB4B, member RAS oncogene family protein (RAB4B) gene, encodes complete protein.
AF498935 - Homo sapiens small GTP binding protein RAB4B (RAB4B) mRNA, complete cds.
AF217985 - Homo sapiens clone PP1596 unknown mRNA.
AK024845 - Homo sapiens cDNA: FLJ21192 fis, clone COL00107, highly similar to AF165522 Homo sapiens ras-related GTP-binding protein 4b (RAB4B) mRNA.
AL832506 - Homo sapiens mRNA; cDNA DKFZp686I0852 (from clone DKFZp686I0852).
AK074408 - Homo sapiens cDNA FLJ23828 fis, clone HUV00950, highly similar to Homo sapiens mRNA for EGLN2 protein.
BC001723 - Homo sapiens egl nine homolog 2 (C. elegans), mRNA (cDNA clone IMAGE:3534835), complete cds.
JD458863 - Sequence 439887 from Patent EP1572962.
BC036051 - Homo sapiens egl nine homolog 2 (C. elegans), mRNA (cDNA clone MGC:33373 IMAGE:5270945), complete cds.
AK098182 - Homo sapiens cDNA FLJ40863 fis, clone TRACH2018317, moderately similar to Rattus norvegicus Sprague-Dawley SM-20 mRNA.
AJ310544 - Homo sapiens mRNA for EGLN2 protein.
AY040565 - Homo sapiens estrogen-induced tag 6 (EIT6) mRNA, complete cds.
JD056165 - Sequence 37189 from Patent EP1572962.
JD319098 - Sequence 300122 from Patent EP1572962.
JD198751 - Sequence 179775 from Patent EP1572962.
JD350839 - Sequence 331863 from Patent EP1572962.
JD512099 - Sequence 493123 from Patent EP1572962.
JD362740 - Sequence 343764 from Patent EP1572962.
JD540892 - Sequence 521916 from Patent EP1572962.
AB527920 - Synthetic construct DNA, clone: pF1KB0950, Homo sapiens EGLN2 gene for egl nine homolog 2, without stop codon, in Flexi system.
AM393809 - Synthetic construct Homo sapiens clone IMAGE:100002271 for hypothetical protein (EGLN2 gene).
JD161295 - Sequence 142319 from Patent EP1572962.
JD547214 - Sequence 528238 from Patent EP1572962.
JD400044 - Sequence 381068 from Patent EP1572962.
JD161207 - Sequence 142231 from Patent EP1572962.
JD199959 - Sequence 180983 from Patent EP1572962.
JD335493 - Sequence 316517 from Patent EP1572962.
JD209469 - Sequence 190493 from Patent EP1572962.
JD440314 - Sequence 421338 from Patent EP1572962.
JD222750 - Sequence 203774 from Patent EP1572962.
JD338683 - Sequence 319707 from Patent EP1572962.
JD370744 - Sequence 351768 from Patent EP1572962.
JD461529 - Sequence 442553 from Patent EP1572962.
JD438183 - Sequence 419207 from Patent EP1572962.
JD057839 - Sequence 38863 from Patent EP1572962.
JD370823 - Sequence 351847 from Patent EP1572962.
JD439122 - Sequence 420146 from Patent EP1572962.
JD426621 - Sequence 407645 from Patent EP1572962.
JD529045 - Sequence 510069 from Patent EP1572962.
AL133009 - Homo sapiens mRNA; cDNA DKFZp434E026 (from clone DKFZp434E026).
AK314741 - Homo sapiens cDNA, FLJ95603, Homo sapiens egl nine homolog 2 (C. elegans) (EGLN2), transcriptvariant 2, mRNA.
AK026863 - Homo sapiens cDNA: FLJ23210 fis, clone ADSH00819.
CU674844 - Synthetic construct Homo sapiens gateway clone IMAGE:100018520 5' read EGLN2 mRNA.
KJ904954 - Synthetic construct Homo sapiens clone ccsbBroadEn_14348 EGLN2 gene, encodes complete protein.
AK025396 - Homo sapiens cDNA: FLJ21743 fis, clone COLF4953.
JD514770 - Sequence 495794 from Patent EP1572962.
JD510087 - Sequence 491111 from Patent EP1572962.
JD459473 - Sequence 440497 from Patent EP1572962.
JD130404 - Sequence 111428 from Patent EP1572962.
JD260242 - Sequence 241266 from Patent EP1572962.
JD420704 - Sequence 401728 from Patent EP1572962.
JD282634 - Sequence 263658 from Patent EP1572962.
JD559380 - Sequence 540404 from Patent EP1572962.
JD194512 - Sequence 175536 from Patent EP1572962.
JD439572 - Sequence 420596 from Patent EP1572962.
JD133493 - Sequence 114517 from Patent EP1572962.
JD114233 - Sequence 95257 from Patent EP1572962.
JD311257 - Sequence 292281 from Patent EP1572962.
JD247358 - Sequence 228382 from Patent EP1572962.
JD483152 - Sequence 464176 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A0A024R0K8, NR_037791, uc060yxf.1, uc060yxf.2
UCSC ID: uc060yxf.2
RefSeq Accession: NR_037791
CCDS: CCDS33030.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.