Human Gene RAB4B-EGLN2 (ENST00000594136.2) Description and Page Index
Description: Homo sapiens RAB4B-EGLN2 readthrough (NMD candidate) (RAB4B-EGLN2), long non-coding RNA. (from RefSeq NR_037791) RefSeq Summary (NR_037791): This locus represents naturally occurring read-through transcription between the neighboring RAB4B (RAB4B, member RAS oncogene family) and EGLN2 (egl nine homolog 2) genes on chromosome 19. The read-through transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is thus unlikely to produce a protein product. [provided by RefSeq, Feb 2011]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AK291385.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## readthrough transcript :: includes exons from GeneID 53916, 112398 ##RefSeq-Attributes-END## Gencode Transcript: ENST00000594136.2 Gencode Gene: ENSG00000171570.11 Transcript (Including UTRs) Position: hg38 chr19:40,778,271-40,808,418 Size: 30,148 Total Exon Count: 12 Strand: + Coding Region Position: hg38 chr19:40,778,376-40,786,963 Size: 8,588 Coding Exon Count: 7
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.