Human Gene CAMK1D (ENST00000619168.5) Description and Page Index
  Description: Homo sapiens calcium/calmodulin dependent protein kinase ID (CAMK1D), transcript variant 2, mRNA. (from RefSeq NM_153498)
RefSeq Summary (NM_153498): This gene is a member of the calcium/calmodulin-dependent protein kinase 1 family, a subfamily of the serine/threonine kinases. The encoded protein is a component of the calcium-regulated calmodulin-dependent protein kinase cascade. It has been associated with multiple processes including regulation of granulocyte function, activation of CREB-dependent gene transcription, aldosterone synthesis, differentiation and activation of neutrophil cells, and apoptosis of erythroleukemia cells. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq, Jan 2015].
Gencode Transcript: ENST00000619168.5
Gencode Gene: ENSG00000183049.13
Transcript (Including UTRs)
   Position: hg38 chr10:12,349,547-12,835,545 Size: 485,999 Total Exon Count: 11 Strand: +
Coding Region
   Position: hg38 chr10:12,349,819-12,828,887 Size: 479,069 Coding Exon Count: 11 

Page IndexSequence and LinksUniProtKB CommentsCTDMicroarray ExpressionRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2021-01-14 15:32:12

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr10:12,349,547-12,835,545)mRNA (may differ from genome)Protein (385 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Calcium/calmodulin-dependent protein kinase type 1D; EC=; AltName: Full=CaM kinase I delta; Short=CaM kinase ID; Short=CaM-KI delta; Short=CaMKI delta; Short=CaMKID; AltName: Full=CaMKI-like protein kinase; Short=CKLiK;
FUNCTION: Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respiratory burst and basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratory burst. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta.
CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
ENZYME REGULATION: Activated by Ca(2+)/calmodulin. Binding of calmodulin results in conformational change that relieves intrasteric autoinhibition and allows phosphorylation of Thr-180 within the activation loop by CaMKK1 or CaMKK2. Phosphorylation of Thr-180 results in several fold increase in total activity. Unlike CaMK4, may be unable to exhibit autonomous activity after Ca(2+)/calmodulin activation.
SUBCELLULAR LOCATION: Cytoplasm (Probable). Nucleus (Probable). Note=Predominantly cytoplasmic. Nuclear localization increases upon activation by KCl treatment in hippocampal neurons.
TISSUE SPECIFICITY: Widely expressed. Highly and mostly expressed in polymorphonuclear leukocytes (neutrophilic and eosinophilic granulocytes) while little or no expression is observed in monocytes and lymphocytes.
DEVELOPMENTAL STAGE: Expressed during hippocampal formation with high expression in the pyramidal cell layers.
INDUCTION: Expression increases upon treatment of EC cells with DMSO and retinoic acid. Induced by KCL in PC12 cells.
DOMAIN: The autoinhibitory domain overlaps with the calmodulin binding region and interacts in the inactive folded state with the catalytic domain as a pseudosubstrate (By similarity).
SIMILARITY: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
SIMILARITY: Contains 1 protein kinase domain.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -136.50272-0.502 Picture PostScript Text
3' UTR -2248.106658-0.338 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR020636 - Ca/CaM-dep_Ca-dep_prot_Kinase
IPR011009 - Kinase-like_dom
IPR000719 - Prot_kinase_cat_dom
IPR017441 - Protein_kinase_ATP_BS
IPR002290 - Ser/Thr_dual-sp_kinase_dom
IPR008271 - Ser/Thr_kinase_AS

Pfam Domains:
PF00069 - Protein kinase domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help

- X-ray MuPIT

ModBase Predicted Comparative 3D Structure on Q8IU85
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologGenome BrowserNo orthologGenome Browser
Gene Details    Gene Details
Gene Sorter    Gene Sorter
Protein SequenceProtein Sequence Protein Sequence Protein Sequence
AlignmentAlignment Alignment Alignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0003824 catalytic activity
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004683 calmodulin-dependent protein kinase activity
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity

Biological Process:
GO:0006468 protein phosphorylation
GO:0006954 inflammatory response
GO:0007399 nervous system development
GO:0008152 metabolic process
GO:0010976 positive regulation of neuron projection development
GO:0016310 phosphorylation
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0032793 positive regulation of CREB transcription factor activity
GO:0035556 intracellular signal transduction
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0050766 positive regulation of phagocytosis
GO:0050773 regulation of dendrite development
GO:0060267 positive regulation of respiratory burst
GO:0071622 regulation of granulocyte chemotaxis
GO:0090023 positive regulation of neutrophil chemotaxis

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm

-  Descriptions from all associated GenBank mRNAs
  AK289393 - Homo sapiens cDNA FLJ76987 complete cds, highly similar to Homo sapiens calcium/calmodulin-dependent protein kinase ID (CAMK1D), transcript variant 1, mRNA.
AB081726 - Homo sapiens CaM-KI delta mRNA for CaM-kinase I delta, complete cds.
BC035745 - Homo sapiens calcium/calmodulin-dependent protein kinase ID, mRNA (cDNA clone MGC:46052 IMAGE:5748490), complete cds.
AF286366 - Homo sapiens CamKI-like protein kinase mRNA, complete cds.
CU690184 - Synthetic construct Homo sapiens gateway clone IMAGE:100019187 5' read CAMK1D mRNA.
AB528894 - Synthetic construct DNA, clone: pF1KE0652, Homo sapiens CAMK1D gene for calcium/calmodulin-dependent protein kinase ID, without stop codon, in Flexi system.
KJ899309 - Synthetic construct Homo sapiens clone ccsbBroadEn_08703 CAMK1D gene, encodes complete protein.
KJ905511 - Synthetic construct Homo sapiens clone ccsbBroadEn_15118 CAMK1D gene, encodes complete protein.
DQ892464 - Synthetic construct clone IMAGE:100005094; FLH186561.01X; RZPDo839F1071D calcium/calmodulin-dependent protein kinase ID (CAMK1D) gene, encodes complete protein.
DQ895676 - Synthetic construct Homo sapiens clone IMAGE:100010136; FLH186557.01L; RZPDo839F1061D calcium/calmodulin-dependent protein kinase ID (CAMK1D) gene, encodes complete protein.
KY966262 - Homo sapiens cell line 95T1000 CAMK1D/ANAPC5 fusion mRNA, partial sequence.
JD405742 - Sequence 386766 from Patent EP1572962.
JD453995 - Sequence 435019 from Patent EP1572962.
JD484687 - Sequence 465711 from Patent EP1572962.
JD486109 - Sequence 467133 from Patent EP1572962.
JD549716 - Sequence 530740 from Patent EP1572962.
JD077362 - Sequence 58386 from Patent EP1572962.
JD141444 - Sequence 122468 from Patent EP1572962.
JD126303 - Sequence 107327 from Patent EP1572962.
JD396070 - Sequence 377094 from Patent EP1572962.
JD534110 - Sequence 515134 from Patent EP1572962.
JD265233 - Sequence 246257 from Patent EP1572962.
JD174086 - Sequence 155110 from Patent EP1572962.
JD324646 - Sequence 305670 from Patent EP1572962.
JD148277 - Sequence 129301 from Patent EP1572962.
JD249804 - Sequence 230828 from Patent EP1572962.
JD208683 - Sequence 189707 from Patent EP1572962.
JD050370 - Sequence 31394 from Patent EP1572962.
JD099955 - Sequence 80979 from Patent EP1572962.
JD243323 - Sequence 224347 from Patent EP1572962.
JD315273 - Sequence 296297 from Patent EP1572962.
JD092528 - Sequence 73552 from Patent EP1572962.
JD430283 - Sequence 411307 from Patent EP1572962.
JD529359 - Sequence 510383 from Patent EP1572962.
JD169585 - Sequence 150609 from Patent EP1572962.
JD306268 - Sequence 287292 from Patent EP1572962.
JD306269 - Sequence 287293 from Patent EP1572962.
JD055145 - Sequence 36169 from Patent EP1572962.
JD125537 - Sequence 106561 from Patent EP1572962.
JD125538 - Sequence 106562 from Patent EP1572962.
JD395360 - Sequence 376384 from Patent EP1572962.
JD332658 - Sequence 313682 from Patent EP1572962.
JD080072 - Sequence 61096 from Patent EP1572962.
JD047055 - Sequence 28079 from Patent EP1572962.
JD565071 - Sequence 546095 from Patent EP1572962.
JD539762 - Sequence 520786 from Patent EP1572962.
JD079931 - Sequence 60955 from Patent EP1572962.
JD251476 - Sequence 232500 from Patent EP1572962.
JD229599 - Sequence 210623 from Patent EP1572962.
JD330595 - Sequence 311619 from Patent EP1572962.
JD226473 - Sequence 207497 from Patent EP1572962.
JD326362 - Sequence 307386 from Patent EP1572962.
JD373705 - Sequence 354729 from Patent EP1572962.
JD267023 - Sequence 248047 from Patent EP1572962.
JD320530 - Sequence 301554 from Patent EP1572962.
JD041895 - Sequence 22919 from Patent EP1572962.
JD333850 - Sequence 314874 from Patent EP1572962.
JD507075 - Sequence 488099 from Patent EP1572962.
JD451788 - Sequence 432812 from Patent EP1572962.
JD254848 - Sequence 235872 from Patent EP1572962.
JD090891 - Sequence 71915 from Patent EP1572962.
JD131778 - Sequence 112802 from Patent EP1572962.
JD558182 - Sequence 539206 from Patent EP1572962.
JD068525 - Sequence 49549 from Patent EP1572962.
JD432324 - Sequence 413348 from Patent EP1572962.
JD467165 - Sequence 448189 from Patent EP1572962.
JD536854 - Sequence 517878 from Patent EP1572962.
JD441793 - Sequence 422817 from Patent EP1572962.
JD385412 - Sequence 366436 from Patent EP1572962.
JD204808 - Sequence 185832 from Patent EP1572962.
JD527241 - Sequence 508265 from Patent EP1572962.
JD541811 - Sequence 522835 from Patent EP1572962.
JD542745 - Sequence 523769 from Patent EP1572962.
JD212723 - Sequence 193747 from Patent EP1572962.
JD198113 - Sequence 179137 from Patent EP1572962.
JD198112 - Sequence 179136 from Patent EP1572962.
JD413414 - Sequence 394438 from Patent EP1572962.
JD413413 - Sequence 394437 from Patent EP1572962.
JD084229 - Sequence 65253 from Patent EP1572962.
JD182686 - Sequence 163710 from Patent EP1572962.
JD206738 - Sequence 187762 from Patent EP1572962.
JD246963 - Sequence 227987 from Patent EP1572962.
JD246962 - Sequence 227986 from Patent EP1572962.
JD537304 - Sequence 518328 from Patent EP1572962.
JD141169 - Sequence 122193 from Patent EP1572962.
JD167585 - Sequence 148609 from Patent EP1572962.
JD362258 - Sequence 343282 from Patent EP1572962.
JD486909 - Sequence 467933 from Patent EP1572962.
JD350761 - Sequence 331785 from Patent EP1572962.
JD511638 - Sequence 492662 from Patent EP1572962.
JD527741 - Sequence 508765 from Patent EP1572962.
JD161764 - Sequence 142788 from Patent EP1572962.
JD481670 - Sequence 462694 from Patent EP1572962.
JD368065 - Sequence 349089 from Patent EP1572962.
JD081188 - Sequence 62212 from Patent EP1572962.
JD333800 - Sequence 314824 from Patent EP1572962.
JD454741 - Sequence 435765 from Patent EP1572962.
JD465116 - Sequence 446140 from Patent EP1572962.
JD519207 - Sequence 500231 from Patent EP1572962.
JD527740 - Sequence 508764 from Patent EP1572962.
JD300662 - Sequence 281686 from Patent EP1572962.
AK097377 - Homo sapiens cDNA FLJ40058 fis, clone TCOLN1000180.
JD374467 - Sequence 355491 from Patent EP1572962.
BC073155 - Homo sapiens hypothetical protein LOC283070, mRNA (cDNA clone IMAGE:6012501), partial cds.
JD039906 - Sequence 20930 from Patent EP1572962.
JD330101 - Sequence 311125 from Patent EP1572962.
JD133706 - Sequence 114730 from Patent EP1572962.
JD088508 - Sequence 69532 from Patent EP1572962.
JD089329 - Sequence 70353 from Patent EP1572962.
JD189520 - Sequence 170544 from Patent EP1572962.
JD391757 - Sequence 372781 from Patent EP1572962.
JD286184 - Sequence 267208 from Patent EP1572962.
JD556224 - Sequence 537248 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B0YIY0, CAMKID, ENST00000619168.1, ENST00000619168.2, ENST00000619168.3, ENST00000619168.4, KCC1D_HUMAN, NM_153498, Q8IU85, Q9HD31, uc001ilp.1, uc001ilp.2, uc001ilp.3, uc001ilp.4, uc001ilp.5, uc001ilp.6
UCSC ID: ENST00000619168.5
RefSeq Accession: NM_153498
Protein: Q8IU85 (aka KCC1D_HUMAN)
CCDS: CCDS7091.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.