Human Gene EHMT1 (ENST00000637161.1) Description and Page Index
Description: euchromatic histone lysine methyltransferase 1 (from HGNC EHMT1) RefSeq Summary (NM_024757): The protein encoded by this gene is a histone methyltransferase that methylates the lysine-9 position of histone H3. This action marks the genomic region packaged with these methylated histones for transcriptional repression. This protein may be involved in the silencing of MYC- and E2F-responsive genes and therefore could play a role in the G0/G1 cell cycle transition. Defects in this gene are a cause of chromosome 9q subtelomeric deletion syndrome (9q-syndrome, also known as Kleefstra syndrome). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2017]. Gencode Transcript: ENST00000637161.1 Gencode Gene: ENSG00000181090.21 Transcript (Including UTRs) Position: hg38 chr9:137,675,186-137,836,100 Size: 160,915 Total Exon Count: 27 Strand: + Coding Region Position: hg38 chr9:137,716,634-137,834,953 Size: 118,320 Coding Exon Count: 25
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.