Human Gene FOXP1 (ENST00000649431.1) Description and Page Index
  Description: forkhead box P1 (from HGNC FOXP1)
RefSeq Summary (NM_001244816): This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
Gencode Transcript: ENST00000649431.1
Gencode Gene: ENSG00000114861.20
Transcript (Including UTRs)
   Position: hg38 chr3:70,959,181-71,306,033 Size: 346,853 Total Exon Count: 19 Strand: -
Coding Region
   Position: hg38 chr3:70,959,247-71,198,381 Size: 239,135 Coding Exon Count: 16 

Page IndexSequence and LinksMalaCardsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureOther SpeciesmRNA DescriptionsOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:70,959,181-71,306,033)mRNA (may differ from genome)Protein (672 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblExonPrimerGeneCardsHGNCLynx
MGImyGene2PubMedStanford SOURCEUniProtKBWikipedia

-  MalaCards Disease Associations
  MalaCards Gene Search: FOXP1
Diseases sorted by gene-association score: mental retardation with language impairment and with or without autistic features* (1550), lymphoma, malt, somatic* (183), mental retardation with language impairment and autistic features* (131), leukemia, acute lymphoblastic 3* (90), relapsed/refractory diffuse large b-cell lymphoma (18), b-cell lymphomas (10), speech disorder (10), testicular lymphoma (9), diffuse large b-cell lymphoma (8), central nervous system lymphoma (8), blepharophimosis (7), speech and communication disorders (2)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 12.51 RPKM in Esophagus - Muscularis
Total median expression: 227.13 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -57.20241-0.237 Picture PostScript Text
3' UTR -10.6066-0.161 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Descriptions from all associated GenBank mRNAs
  AF250920 - Homo sapiens 12CC4 mRNA, complete cds.
BC131720 - Homo sapiens forkhead box P1, mRNA (cDNA clone IMAGE:40123493), partial cds.
BC054505 - Homo sapiens forkhead box P1, mRNA (cDNA clone IMAGE:5503553), with apparent retained intron.
BC068481 - Homo sapiens cDNA clone IMAGE:4813876, containing frame-shift errors.
AK122710 - Homo sapiens cDNA FLJ16198 fis, clone CTONG1000220, highly similar to Forkhead box protein P1.
AF146696 - Homo sapiens clone pAB195 FOXP1 (FOXP1) mRNA, complete cds.
AK092383 - Homo sapiens cDNA FLJ35064 fis, clone PEBLM1000147, moderately similar to Glutamine (Q)-rich factor 1, QRF-1.
AX747510 - Sequence 1035 from Patent EP1308459.
BC005055 - Homo sapiens forkhead box P1, mRNA (cDNA clone IMAGE:2823199), complete cds.
BC054815 - Homo sapiens forkhead box P1, mRNA (cDNA clone IMAGE:5017122), complete cds.
BC071893 - Homo sapiens forkhead box P1, mRNA (cDNA clone IMAGE:3537501), complete cds.
BC080521 - Homo sapiens forkhead box P1, mRNA (cDNA clone IMAGE:3537750), complete cds.
DQ845346 - Homo sapiens PAX5/FOXP1 fusion protein (PAX5/FOXP1 fusion) mRNA, complete cds.
AK297649 - Homo sapiens cDNA FLJ58267 complete cds, highly similar to Forkhead box protein P1.
AF146698 - Homo sapiens FOXP1 (FOXP1) mRNA, complete cds.
AF146697 - Homo sapiens clone pAB196 FOXP1 (FOXP1) mRNA, partial cds.
AK027264 - Homo sapiens cDNA FLJ14358 fis, clone HEMBA1000158, weakly similar to HEPATOCYTE NUCLEAR FACTOR 3-GAMMA.
AB052767 - Homo sapiens hFKHLB mRNA for fork head-related protein like B, complete cds.
AF275309 - Homo sapiens transcription factor FOXP1 (FOXP1) mRNA, partial cds.
AK074321 - Homo sapiens cDNA FLJ23741 fis, clone HEP15377.
AK074569 - Homo sapiens cDNA FLJ90088 fis, clone HEMBA1005246.
BC152752 - Synthetic construct Homo sapiens clone IMAGE:100015965, MGC:184148 forkhead box P1 (FOXP1) mRNA, encodes complete protein.
AB527726 - Synthetic construct DNA, clone: pF1KB6240, Homo sapiens FOXP1 gene for forkhead box P1, without stop codon, in Flexi system.
BX647682 - Homo sapiens mRNA; cDNA DKFZp686K12112 (from clone DKFZp686K12112).
AF151049 - Homo sapiens HSPC215 mRNA, complete cds.
CR457164 - Homo sapiens full open reading frame cDNA clone RZPDo834B098D for gene FOXP1, forkhead box P1; complete cds, incl. stopcodon.
JD370757 - Sequence 351781 from Patent EP1572962.
KJ893597 - Synthetic construct Homo sapiens clone ccsbBroadEn_02991 FOXP1 gene, encodes complete protein.
BT006643 - Homo sapiens forkhead box P1 mRNA, complete cds.

-  Other Names for This Gene
  Alternate Gene Symbols: A0A3B3IUB6, AF250920, uc285uit.1
UCSC ID: uc285uit.1
RefSeq Accession: NM_001244816
CCDS: CCDS2914.1, CCDS58839.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.