Mouse Gene Napb (R8396) Description and Page Index
  Description: N-ethylmaleimide sensitive fusion protein
Transcript (Including UTRs)
   Position: mm8 chr2:148,386,098-148,423,861 Size: 37,764 Total Exon Count: 11 Strand: -
Coding Region
   Position: mm8 chr2:148,388,837-148,423,804 Size: 34,968 Coding Exon Count: 11 

Page IndexSequence and LinksUniProtKB CommentsCTDMicroarray ExpressionRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther Names
Methods
Data last updated: 2006-02-27

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:148,386,098-148,423,861)mRNA (may differ from genome)Protein (298 aa)
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-  Comments and Description Text from UniProtKB
  ID: SNAB_MOUSE
DESCRIPTION: RecName: Full=Beta-soluble NSF attachment protein; Short=SNAP-beta; AltName: Full=Brain protein I47; AltName: Full=N-ethylmaleimide-sensitive factor attachment protein beta;
FUNCTION: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.
SUBUNIT: Interacts with PRKCABP, and disrupts the interaction between GRIA2 and PRKCABP, leading to the internalization of GRIA2 (By similarity).
SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein.
TISSUE SPECIFICITY: Cerebral cortex, cerebellar cortex, hippocampus, and dentate gyrus, weakly expressed in the putamen, the thalamus and the brain stem.
SIMILARITY: Belongs to the SNAP family.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  Microarray Expression Data
 
Expression ratio colors:

Rinn et. al Sex Gene Expression Data on MOE430A Chip

        
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Absolute

GNF Expression Atlas Data from U74a Mouse Chip

        
     
    
    
    
   
    
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Affymetrix All Exon Microarrays

           
Ratios

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -21.1057-0.370 Picture PostScript Text
3' UTR -827.692739-0.302 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000744 - NSF_attach
IPR011990 - TPR-like_helical

ModBase Predicted Comparative 3D Structure on P28663
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserNo orthologGenome BrowserNo orthologGenome BrowserGenome Browser
Gene Details   Gene DetailsGene Details
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GenBank Ensembl WormBaseSGD
Protein Sequence Protein Sequence Protein SequenceProtein Sequence
Alignment Alignment AlignmentAlignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000149 SNARE binding
GO:0005483 soluble NSF attachment protein activity
GO:0005515 protein binding
GO:0019905 syntaxin binding

Biological Process:
GO:0002090 regulation of receptor internalization
GO:0006886 intracellular protein transport
GO:0010807 regulation of synaptic vesicle priming
GO:0015031 protein transport
GO:0016192 vesicle-mediated transport
GO:0032984 macromolecular complex disassembly
GO:0035249 synaptic transmission, glutamatergic
GO:0035494 SNARE complex disassembly
GO:0043462 regulation of ATPase activity
GO:0048488 synaptic vesicle endocytosis
GO:0061025 membrane fusion

Cellular Component:
GO:0005774 vacuolar membrane
GO:0016020 membrane
GO:0043209 myelin sheath
GO:0045202 synapse
GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex


-  Descriptions from all associated GenBank mRNAs
  AK043917 - Mus musculus 10 days neonate cortex cDNA, RIKEN full-length enriched library, clone:A830050L07 product:weakly similar to BRAIN PROTEIN E161 [Mus musculus], full insert sequence.
AK039204 - Mus musculus adult male hypothalamus cDNA, RIKEN full-length enriched library, clone:A230107G18 product:BRAIN PROTEIN E161 homolog [Mus musculus], full insert sequence.
AK048037 - Mus musculus 16 days embryo head cDNA, RIKEN full-length enriched library, clone:C130031E12 product:weakly similar to BRAIN PROTEIN E161 [Mus musculus], full insert sequence.
BC016125 - Mus musculus N-ethylmaleimide sensitive fusion protein attachment protein beta, mRNA (cDNA clone IMAGE:4511954), complete cds.
BC038362 - Mus musculus N-ethylmaleimide sensitive fusion protein attachment protein beta, mRNA (cDNA clone MGC:36510 IMAGE:5368175), complete cds.
AK083184 - Mus musculus adult male hippocampus cDNA, RIKEN full-length enriched library, clone:C630024D19 product:N-ethylmaleimide sensitive fusion protein attachment protein beta, full insert sequence.
X61450 - M.musculus mRNA for clone E161.
BC049874 - Mus musculus N-ethylmaleimide sensitive fusion protein attachment protein beta, mRNA (cDNA clone MGC:54909 IMAGE:5360432), complete cds.
DQ698482 - Mus musculus piRNA piR-113804, complete sequence.
X61455 - M.musculus mRNA for I47 clone.
AK078224 - Mus musculus adult male olfactory brain cDNA, RIKEN full-length enriched library, clone:6430524F19 product:N-ethylmaleimide sensitive fusion protein attachment protein beta, full insert sequence.
LF264524 - JP 2014500723-A/72027: Polycomb-Associated Non-Coding RNAs.
LF193644 - JP 2014500723-A/1147: Polycomb-Associated Non-Coding RNAs.
LF193645 - JP 2014500723-A/1148: Polycomb-Associated Non-Coding RNAs.
MA429221 - JP 2018138019-A/1147: Polycomb-Associated Non-Coding RNAs.
MA429222 - JP 2018138019-A/1148: Polycomb-Associated Non-Coding RNAs.
MA500101 - JP 2018138019-A/72027: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P28663 (Reactome details) participates in the following event(s):

R-MMU-5694423 NSF and SNAPs bind cis-SNARE complex
R-MMU-6809014 cis-Golgi cis-SNARE binds NSF and SNAPs
R-MMU-6811425 NSF and SNAPs bind cis-SNARE at the ER membrane
R-MMU-6814676 SNAPs and NSF hexamer bind cis-SNARE at the TGN
R-MMU-6814684 cis-SNARE binds SNAPs and NSF hexamer at the TGN
R-MMU-8847637 NSF and SNAPs bind the cis-SNARE at the Golgi
R-MMU-5694425 NSF ATPase activity dissociates cis-SNARE
R-MMU-6811422 NSF ATPase activity dissociates cis-SNARE at the ER
R-MMU-6814683 NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN
R-MMU-8847638 ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane
R-MMU-204005 COPII-mediated vesicle transport
R-MMU-6807878 COPI-mediated anterograde transport
R-MMU-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-MMU-6811440 Retrograde transport at the Trans-Golgi-Network
R-MMU-6811438 Intra-Golgi traffic
R-MMU-199977 ER to Golgi Anterograde Transport
R-MMU-8856688 Golgi-to-ER retrograde transport
R-MMU-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic
R-MMU-199991 Membrane Trafficking
R-MMU-948021 Transport to the Golgi and subsequent modification
R-MMU-5653656 Vesicle-mediated transport
R-MMU-446203 Asparagine N-linked glycosylation
R-MMU-597592 Post-translational protein modification
R-MMU-392499 Metabolism of proteins

-  Other Names for This Gene
  Alternate Gene Symbols: AK083184, BC038362, BC049874, SNAP-BETA, Snapb
UCSC ID: NM_019632
RefSeq Accession: NM_019632
Protein: P28663 (aka SNAB_MOUSE)
CCDS: CCDS16842.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.