ID:RIMS1_RAT DESCRIPTION: RecName: Full=Regulating synaptic membrane exocytosis protein 1; AltName: Full=Rab-3-interacting molecule 1; Short=RIM 1; FUNCTION: Rab effector involved in exocytosis. May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short- term synaptic plasticity (By similarity). SUBUNIT: Binds SNAP25, SYT1 and CACNA1B. Interaction with SYT1 is enhanced by calcium ions. Interaction with SNAP25 is weaker in the presence of calcium ions. Binds RAB3A, RAB3B and RAB3D that have been activated by GTP-binding. Binds UNC13A. Binds RIM binding proteins 1 and 2. Interacts with PPFIA3 and PPFIA4. INTERACTION: O70368:Cacna1a; NbExp=2; IntAct=EBI-3507436, EBI-3507514; P54282:Cacna1a; NbExp=4; IntAct=EBI-3507436, EBI-3507416; O89089:Cacna1b; NbExp=2; IntAct=EBI-3507436, EBI-3507539; SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein. Cell junction, synapse. Cell junction, synapse, presynaptic cell membrane; Peripheral membrane protein (Potential). Note=Associated with plasma membranes from synaptic junctions. Not detected in synaptic vesicles. Detected in presynaptic nerve terminals close to the active zone. Detected in synaptic ribbons of ribbon synapses of retinal photoreceptor cells. TISSUE SPECIFICITY: Highly expressed in hippocampus, brain cortex, cerebellum and olfactory bulb. Detected at lower levels in midbrain, hindbrain and spinal cord. Detected retina and in spinal cord motor neurons. PTM: Phosphorylated by BRSK1. SIMILARITY: Contains 2 C2 domains. SIMILARITY: Contains 1 FYVE-type zinc finger. SIMILARITY: Contains 1 PDZ (DHR) domain. SIMILARITY: Contains 1 RabBD (Rab-binding) domain.
ModBase Predicted Comparative 3D Structure on Q9JIR4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.