Rat Gene Fgf14 (RGD:620165) Description and Page Index
  Description: exhibits transforming growth factor activity
Transcript (Including UTRs)
   Position: rn4 chr15:109,057,275-109,297,945 Size: 240,671 Total Exon Count: 4 Strand: -
Coding Region
   Position: rn4 chr15:109,057,275-109,297,945 Size: 240,671 Coding Exon Count: 4 

Page IndexSequence and LinksRGD Gene DataUniProtKB CommentsCTDMicroarray Expression
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther Names
Methods
Data last updated: 2011-12-07

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr15:109,057,275-109,297,945)mRNAProtein (211 aa)
Gene SorterOther Species FASTAEnsemblEntrez GeneGeneNetworkPubMed
ReactomeRGDStanford SOURCEUniProtKB

-  Additional Data from RGD
  RGD Gene: 620165
Gene Symbol: Fgf14
Name: fibroblast growth factor 14
Curated Pubmed Papers: 1824921, 9602045
Uncurated Pubmed Papers: 708320, 632810
Entrez Gene: 63851
UniProt: Q8R4X0, Q8R5L7
GenBank Nucleotide: AB008908, AB079500, AF348523, CH473951, NM_022223
Genebank Protein: AAL83904, BAA31544, BAB84580, EDM02595, EDM02596, NP_071559, Q794I6, Q8R4X0, Q8R5L7, NP_071559.2
UniGene: 44476
Ensembl Gene: ENSRNOG00000009288, ENSRNOG00000009288

-  Comments and Description Text from UniProtKB
  ID: FGF14_RAT
DESCRIPTION: RecName: Full=Fibroblast growth factor 14; Short=FGF-14;
FUNCTION: Probably involved in nervous system development and function (By similarity).
SUBCELLULAR LOCATION: Nucleus (Probable).
SIMILARITY: Belongs to the heparin-binding growth factors family.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  Microarray Expression Data
 
Expression ratio colors:

GNF Expression Atlas 2 Data from U34A Rat Chip

      
      
      
    
     
    
   
Ratios
      
      
      
    
     
    
   
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Absolute

Affymetrix All Exon Microarrays

           
Ratios

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR008996 - Cytokine_IL1-like
IPR002209 - GF_heparin-bd
IPR002348 - IL1_HBGF

Pfam Domains:
PF00167 - Fibroblast growth factor

ModBase Predicted Comparative 3D Structure on Q8R5L7
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanMouseZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
  Ensembl   
  Protein Sequence   
  Alignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0008083 growth factor activity

Biological Process:
GO:0007399 nervous system development
GO:0010469 regulation of receptor activity
GO:0048167 regulation of synaptic plasticity
GO:0060078 regulation of postsynaptic membrane potential
GO:1901843 positive regulation of high voltage-gated calcium channel activity
GO:1903421 regulation of synaptic vesicle recycling

Cellular Component:
GO:0005576 extracellular region
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  AB079500 - Rattus norvegicus FGF14 mRNA for fibroblast growth factor14, complete cds.
AB008908 - Rattus norvegicus Fgf14b mRNA for fibroblast growth factor 14b, complete cds.
AF348523 - Rattus norvegicus fibroblast growth factor-like factor 4D mRNA, partial cds.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
rno04010 - MAPK signaling pathway
rno04810 - Regulation of actin cytoskeleton
rno05200 - Pathways in cancer
rno05218 - Melanoma

-  Other Names for This Gene
  Symbol: Fhf4
Name: FGF homologus factor 4b, FGF-14, fibroblast growth factor 14, fibroblast growth factor homologous factor 4
RefSeq Accession: NM_022223
Protein: Q8R5L7 (aka FGF14_RAT or FGFE_RAT)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.