Human Gene ACAP3 (uc001aeb.1) Description and Page Index
  Description: ArfGAP with coiled-coil, ankyrin repeat and PH
Transcript (Including UTRs)
   Position: hg18 chr1:1,218,807-1,233,132 Size: 14,326 Total Exon Count: 24 Strand: -
Coding Region
   Position: hg18 chr1:1,218,807-1,233,058 Size: 14,252 Coding Exon Count: 24 

Page IndexSequence and LinksUniProtKB CommentsCTDMicroarray ExpressionRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated: 2009-03-03

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:1,218,807-1,233,132)mRNA (may differ from genome)Protein (834 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCMGIPubMedStanford SOURCE
TreefamUniProtKB

-  Comments and Description Text from UniProtKB
  ID: ACAP3_HUMAN
DESCRIPTION: RecName: Full=Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3; AltName: Full=Centaurin-beta-5; Short=Cnt-b5;
FUNCTION: GTPase-activating protein for the ADP ribosylation factor family (Potential).
SIMILARITY: Contains 3 ANK repeats.
SIMILARITY: Contains 1 Arf-GAP domain.
SIMILARITY: Contains 1 PH domain.
SEQUENCE CAUTION: Sequence=BAB21807.1; Type=Erroneous initiation;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  Microarray Expression Data
 
Expression ratio colors:

Affymetrix All Exon Microarrays

           
Ratios

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -44.8074-0.605 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002110 - Ankyrin_rpt
IPR020683 - Ankyrin_rpt-contain_dom
IPR001164 - ArfGAP
IPR013606 - IRSp53/MIM_homology_IMD
IPR011993 - PH_like_dom
IPR001849 - Pleckstrin_homology

Pfam Domains:
PF01412 - Putative GTPase activating protein for Arf
PF00169 - PH domain
PF00023 - Ankyrin repeat

SCOP Domains:
50729 - PH domain-like
48403 - Ankyrin repeat
57863 - Pyk2-associated protein beta ARF-GAP domain

ModBase Predicted Comparative 3D Structure on Q96P50
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserNo orthologNo orthologNo orthologNo orthologGenome Browser
Gene Details    Gene Details
Gene Sorter    Gene Sorter
MGI    SGD
Protein Sequence    Protein Sequence
Alignment    Alignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005096 GTPase activator activity
GO:0046872 metal ion binding

Biological Process:
GO:0043547 positive regulation of GTPase activity


-  Descriptions from all associated GenBank mRNAs
  BC021851 - Homo sapiens ArfGAP with coiled-coil, ankyrin repeat and PH domains 3, mRNA (cDNA clone IMAGE:4914469), partial cds.
AB051503 - Homo sapiens mRNA for KIAA1716 protein, partial cds.
BC004874 - Homo sapiens ArfGAP with coiled-coil, ankyrin repeat and PH domains 3, mRNA (cDNA clone IMAGE:3687515), partial cds.
BC051194 - Homo sapiens ArfGAP with coiled-coil, ankyrin repeat and PH domains 3, mRNA (cDNA clone MGC:57293 IMAGE:4819254), complete cds.
BC029929 - Homo sapiens ArfGAP with coiled-coil, ankyrin repeat and PH domains 3, mRNA (cDNA clone IMAGE:5166729), partial cds.
BC047001 - Homo sapiens centaurin, beta 5, mRNA (cDNA clone IMAGE:3874217).
AK093954 - Homo sapiens cDNA FLJ36635 fis, clone TRACH2018835, moderately similar to Homo sapiens mRNA for centaurin beta2.
AX748381 - Sequence 1906 from Patent EP1308459.
AF411981 - Homo sapiens centaurin beta5 mRNA, complete cds.
AB384270 - Synthetic construct DNA, clone: pF1KSDA1716, Homo sapiens CENTB5 gene for centaurin-beta 5, complete cds, without stop codon, in Flexi system.
AK098490 - Homo sapiens cDNA FLJ25624 fis, clone STM02925.
JD479781 - Sequence 460805 from Patent EP1572962.
KJ900044 - Synthetic construct Homo sapiens clone ccsbBroadEn_09438 ACAP3 gene, encodes complete protein.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04144 - Endocytosis

-  Other Names for This Gene
  Alternate Gene Symbols: B1AMF5, B1AMF5_HUMAN, BC051194, CENTB5, NM_030649, NP_085152, RP5-902P8.11-003
UCSC ID: uc001aeb.1
RefSeq Accession: NM_030649
Protein: Q96P50 (aka ACAP3_HUMAN)

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: BC051194.1
exon count: 24CDS single in 3' UTR: no RNA size: 3766
ORF size: 2505CDS single in intron: no Alignment % ID: 99.97
txCdsPredict score: 4732.50frame shift in genome: no % Coverage: 68.48
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.