Human Gene MTF2 (uc001dpi.2) Description and Page Index
  Description: Metal-response element-binding transcription factor 2 (Metal-response element DNA-binding protein M96) (Metal regulatory transcription factor 2) (Polycomb-like protein 2) (hPCl2).
Transcript (Including UTRs)
   Position: hg18 chr1:93,317,380-93,377,226 Size: 59,847 Total Exon Count: 14 Strand: +
Coding Region
   Position: hg18 chr1:93,356,553-93,375,172 Size: 18,620 Coding Exon Count: 8 

Page IndexSequence and LinksCTDMicroarray ExpressionRNA StructureProtein Structure
Other SpeciesmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2009-03-03

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr1:93,317,380-93,377,226)mRNA (may differ from genome)Protein (320 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  Microarray Expression Data
Expression ratio colors:

GNF Expression Atlas 2 Data from U133A and GNF1H Chips


Affymetrix All Exon Microarrays


-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -327.92987-0.332 Picture PostScript Text
3' UTR -488.592054-0.238 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  ModBase Predicted Comparative 3D Structure on Q9Y483-2
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein Sequence     

-  Descriptions from all associated GenBank mRNAs
  AK302900 - Homo sapiens cDNA FLJ50106 complete cds, highly similar to Metal-response element-binding transcriptionfactor 2.
AK290318 - Homo sapiens cDNA FLJ77043 complete cds, highly similar to Homo sapiens metal response element binding transcription factor 2 (MTF2), mRNA.
AJ010014 - Homo sapiens mRNA for M96A protein.
AK302776 - Homo sapiens cDNA FLJ50925 complete cds, highly similar to Metal-response element-binding transcription factor 2.
AF086908 - Homo sapiens M96A-2 mRNA, complete cds.
BC010013 - Homo sapiens metal response element binding transcription factor 2, mRNA (cDNA clone MGC:15320 IMAGE:4308565), complete cds.
BC001897 - Homo sapiens metal response element binding transcription factor 2, mRNA (cDNA clone IMAGE:3533448).
LP895148 - Sequence 12 from Patent EP3253886.
JD307482 - Sequence 288506 from Patent EP1572962.
JD218546 - Sequence 199570 from Patent EP1572962.
CU679573 - Synthetic construct Homo sapiens gateway clone IMAGE:100019812 5' read MTF2 mRNA.
AB590608 - Synthetic construct DNA, clone: pFN21AE1164, Homo sapiens MTF2 gene for metal response element binding transcription factor 2, without stop codon, in Flexi system.
AF072814 - Homo sapiens PHD finger DNA binding protein isoform 1 (M96) mRNA, alternatively spliced, complete cds.
AF073293 - Homo sapiens M962 protein spliced isoform 2 mRNA, complete cds.
AF086050 - Homo sapiens full length insert cDNA clone YY61D04.
JD534924 - Sequence 515948 from Patent EP1572962.
JD404115 - Sequence 385139 from Patent EP1572962.
JD357330 - Sequence 338354 from Patent EP1572962.
JD553362 - Sequence 534386 from Patent EP1572962.
KJ893294 - Synthetic construct Homo sapiens clone ccsbBroadEn_02688 MTF2 gene, encodes complete protein.
JD113191 - Sequence 94215 from Patent EP1572962.
JD244252 - Sequence 225276 from Patent EP1572962.
JD343351 - Sequence 324375 from Patent EP1572962.
JD078432 - Sequence 59456 from Patent EP1572962.
LF359225 - JP 2014500723-A/166728: Polycomb-Associated Non-Coding RNAs.
LF359226 - JP 2014500723-A/166729: Polycomb-Associated Non-Coding RNAs.
LF359227 - JP 2014500723-A/166730: Polycomb-Associated Non-Coding RNAs.
LF359228 - JP 2014500723-A/166731: Polycomb-Associated Non-Coding RNAs.
LF359229 - JP 2014500723-A/166732: Polycomb-Associated Non-Coding RNAs.
LF359230 - JP 2014500723-A/166733: Polycomb-Associated Non-Coding RNAs.
LF359231 - JP 2014500723-A/166734: Polycomb-Associated Non-Coding RNAs.
LF359232 - JP 2014500723-A/166735: Polycomb-Associated Non-Coding RNAs.
LF359233 - JP 2014500723-A/166736: Polycomb-Associated Non-Coding RNAs.
MA594802 - JP 2018138019-A/166728: Polycomb-Associated Non-Coding RNAs.
MA594803 - JP 2018138019-A/166729: Polycomb-Associated Non-Coding RNAs.
MA594804 - JP 2018138019-A/166730: Polycomb-Associated Non-Coding RNAs.
MA594805 - JP 2018138019-A/166731: Polycomb-Associated Non-Coding RNAs.
MA594806 - JP 2018138019-A/166732: Polycomb-Associated Non-Coding RNAs.
MA594807 - JP 2018138019-A/166733: Polycomb-Associated Non-Coding RNAs.
MA594808 - JP 2018138019-A/166734: Polycomb-Associated Non-Coding RNAs.
MA594809 - JP 2018138019-A/166735: Polycomb-Associated Non-Coding RNAs.
MA594810 - JP 2018138019-A/166736: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9Y483 (Reactome details) participates in the following event(s):

R-HSA-212263 PRC2 trimethylates histone H3 at lysine-27
R-HSA-212300 PRC2 methylates histones and DNA
R-HSA-212165 Epigenetic regulation of gene expression
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: AF086908, PCL2, Q9Y483-2, uc001dpi.1
UCSC ID: uc001dpi.2
RefSeq Accession: NM_007358
Protein: Q9Y483-2, splice isoform of Q9Y483

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: AF086908.1
exon count: 14CDS single in 3' UTR: no RNA size: 1937
ORF size: 963CDS single in intron: no Alignment % ID: 99.33
txCdsPredict score: 1421.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.