Human Gene CFL1 (ENST00000308162.10)
  Description: Homo sapiens cofilin 1 (CFL1), mRNA. (from RefSeq NM_005507)
RefSeq Summary (NM_005507): The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.[supplied by OMIM, Apr 2004].
Gencode Transcript: ENST00000308162.10
Gencode Gene: ENSG00000172757.13
Transcript (Including UTRs)
   Position: hg38 chr11:65,854,673-65,858,180 Size: 3,508 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg38 chr11:65,855,336-65,858,099 Size: 2,764 Coding Exon Count: 4 

Page IndexSequence and LinksMalaCardsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureOther SpeciesmRNA DescriptionsPathwaysOther NamesMethods
Data last updated at UCSC: 2021-01-14 15:32:12

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr11:65,854,673-65,858,180)mRNA (may differ from genome)Protein (166 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards

-  MalaCards Disease Associations
  MalaCards Gene Search: CFL1
Diseases sorted by gene-association score: corticobasal degeneration (2), autosomal dominant nonsyndromic deafness 20 (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 228.89 RPKM in Whole Blood
Total median expression: 5667.14 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -26.0081-0.321 Picture PostScript Text
3' UTR -222.30663-0.335 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Descriptions from all associated GenBank mRNAs
  LF208097 - JP 2014500723-A/15600: Polycomb-Associated Non-Coding RNAs.
MA443674 - JP 2018138019-A/15600: Polycomb-Associated Non-Coding RNAs.
BC018256 - Homo sapiens cofilin 1 (non-muscle), mRNA (cDNA clone MGC:17447 IMAGE:3448134), complete cds.
BC012318 - Homo sapiens cofilin 1 (non-muscle), mRNA (cDNA clone MGC:15952 IMAGE:3538185), complete cds.
JA482223 - Sequence 206 from Patent WO2011072091.
JE980515 - Sequence 206 from Patent EP2862929.
BC024975 - Homo sapiens cofilin 1 (non-muscle), mRNA (cDNA clone IMAGE:4537759).
AK097690 - Homo sapiens cDNA FLJ40371 fis, clone TESTI2034931, highly similar to Cofilin-1.
X95404 - H.sapiens mRNA for non-muscle type cofilin.
BC012265 - Homo sapiens cofilin 1 (non-muscle), mRNA (cDNA clone MGC:9272 IMAGE:3862540), complete cds.
AK303614 - Homo sapiens cDNA FLJ51435 complete cds, moderately similar to Cofilin-1.
BC011005 - Homo sapiens cofilin 1 (non-muscle), mRNA (cDNA clone MGC:16554 IMAGE:4079579), complete cds.
U21909 - Homo sapiens cofilin mRNA, partial cds.
JD459014 - Sequence 440038 from Patent EP1572962.
LF372230 - JP 2014500723-A/179733: Polycomb-Associated Non-Coding RNAs.
MA607807 - JP 2018138019-A/179733: Polycomb-Associated Non-Coding RNAs.
JD243486 - Sequence 224510 from Patent EP1572962.
JD046698 - Sequence 27722 from Patent EP1572962.
LF372229 - JP 2014500723-A/179732: Polycomb-Associated Non-Coding RNAs.
MA607806 - JP 2018138019-A/179732: Polycomb-Associated Non-Coding RNAs.
JD124263 - Sequence 105287 from Patent EP1572962.
JD188514 - Sequence 169538 from Patent EP1572962.
LF372228 - JP 2014500723-A/179731: Polycomb-Associated Non-Coding RNAs.
MA607805 - JP 2018138019-A/179731: Polycomb-Associated Non-Coding RNAs.
JD157319 - Sequence 138343 from Patent EP1572962.
JD292751 - Sequence 273775 from Patent EP1572962.
JD537114 - Sequence 518138 from Patent EP1572962.
LF372227 - JP 2014500723-A/179730: Polycomb-Associated Non-Coding RNAs.
MA607804 - JP 2018138019-A/179730: Polycomb-Associated Non-Coding RNAs.
JD210544 - Sequence 191568 from Patent EP1572962.
D00682 - Homo sapiens mRNA for cofilin, complete cds.
KJ890901 - Synthetic construct Homo sapiens clone ccsbBroadEn_00295 CFL1 gene, encodes complete protein.
KJ896591 - Synthetic construct Homo sapiens clone ccsbBroadEn_05985 CFL1 gene, encodes complete protein.
BT006846 - Homo sapiens cofilin 1 (non-muscle) mRNA, complete cds.
DQ891769 - Synthetic construct clone IMAGE:100004399; FLH179761.01X; RZPDo839C06132D cofilin 1 (non-muscle) (CFL1) gene, encodes complete protein.
EU176624 - Synthetic construct Homo sapiens clone IMAGE:100011432; FLH179760.01L; RZPDo839C07254D cofilin 1 (non-muscle) (CFL1) gene, encodes complete protein.
EU794603 - Homo sapiens epididymis secretory protein Li 15 (HEL-S-15) mRNA, complete cds.
AB590274 - Synthetic construct DNA, clone: pFN21AE2285, Homo sapiens CFL1 gene for cofilin 1, without stop codon, in Flexi system.
JD025972 - Sequence 6996 from Patent EP1572962.
JD035281 - Sequence 16305 from Patent EP1572962.
LF372225 - JP 2014500723-A/179728: Polycomb-Associated Non-Coding RNAs.
MA607802 - JP 2018138019-A/179728: Polycomb-Associated Non-Coding RNAs.
LF372223 - JP 2014500723-A/179726: Polycomb-Associated Non-Coding RNAs.
MA607800 - JP 2018138019-A/179726: Polycomb-Associated Non-Coding RNAs.
LF372221 - JP 2014500723-A/179724: Polycomb-Associated Non-Coding RNAs.
MA607798 - JP 2018138019-A/179724: Polycomb-Associated Non-Coding RNAs.
HM370399 - Homo sapiens cofilin 1 (CFL1) mRNA, 5' UTR, alternatively spliced.
DQ581881 - Homo sapiens piRNA piR-49993, complete sequence.
D28345 - Homo sapiens mRNA for cofilin, 5'UTR region.
JD261561 - Sequence 242585 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04360 - Axon guidance
hsa04666 - Fc gamma R-mediated phagocytosis
hsa04810 - Regulation of actin cytoskeleton

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000308162.1, ENST00000308162.2, ENST00000308162.3, ENST00000308162.4, ENST00000308162.5, ENST00000308162.6, ENST00000308162.7, ENST00000308162.8, ENST00000308162.9, NM_005507, uc001ofs.1, uc001ofs.2, uc001ofs.3, uc001ofs.4, uc001ofs.5, V9HWI5
UCSC ID: ENST00000308162.10
RefSeq Accession: NM_005507
CCDS: CCDS8114.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.