Human Gene FGF23 (uc001qmq.1) Description and Page Index
  Description: fibroblast growth factor 23 precursor
RefSeq Summary (NM_020638): This gene encodes a member of the fibroblast growth factor family of proteins, which possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. The product of this gene regulates phosphate homeostasis and transport in the kidney. The full-length, functional protein may be deactivated via cleavage into N-terminal and C-terminal chains. Mutation of this cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR). Mutations in this gene are also associated with hyperphosphatemic familial tumoral calcinosis (HFTC). [provided by RefSeq, Feb 2013].
Transcript (Including UTRs)
   Position: hg18 chr12:4,347,654-4,359,155 Size: 11,502 Total Exon Count: 3 Strand: -
Coding Region
   Position: hg18 chr12:4,349,770-4,359,009 Size: 9,240 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathways
Other NamesGeneReviewsModel InformationMethods
Data last updated at UCSC: 2009-03-03

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:4,347,654-4,359,155)mRNA (may differ from genome)Protein (251 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
GeneTestsHGNCHPRDMGIOMIMPubMed
ReactomeTreefamUniProtKB

-  Comments and Description Text from UniProtKB
  ID: FGF23_HUMAN
DESCRIPTION: RecName: Full=Fibroblast growth factor 23; Short=FGF-23; AltName: Full=Phosphatonin; AltName: Full=Tumor-derived hypophosphatemia-inducing factor; Contains: RecName: Full=Fibroblast growth factor 23 N-terminal peptide; Contains: RecName: Full=Fibroblast growth factor 23 C-terminal peptide; Flags: Precursor;
FUNCTION: Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Upregulates EGR1 expression in the presence of KL (By similarity). Acts directly on the parathyroid to decrease PTH secretion (By similarity). Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization.
SUBUNIT: Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by KL and heparan sulfate glycosaminoglycans that function as coreceptors (By similarity).
SUBCELLULAR LOCATION: Secreted. Note=Secretion is dependent on O- glycosylation.
TISSUE SPECIFICITY: Expressed in osteogenic cells particularly during phases of active bone remodeling. In adult trabecular bone, expressed in osteocytes and flattened bone-lining cells (inactive osteoblasts).
PTM: Following secretion this protein is inactivated by cleavage into a N-terminal fragment and a C-terminal fragment. The processing is effected by proprotein convertases.
PTM: O-glycosylated by GALT3. Glycosylation is necessary for secretion; it blocks processing by proprotein convertases when the O-glycan is alpha 2,6-sialylated. Competition between proprotein convertase cleavage and block of cleavage by O-glycosylation determines the level of secreted active FGF23.
DISEASE: Defects in FGF23 are the cause of autosomal dominant hypophosphataemic rickets (ADHR) [MIM:193100]. ADHR is characterized by low serum phosphorus concentrations, rickets, osteomalacia, leg deformities, short stature, bone pain and dental abscesses.
DISEASE: Defects in FGF23 are a cause of hyperphosphatemic familial tumoral calcinosis (HFTC) [MIM:211900]. HFTC is a severe autosomal recessive metabolic disorder that manifests with hyperphosphatemia and massive calcium deposits in the skin and subcutaneous tissues.
SIMILARITY: Belongs to the heparin-binding growth factors family.
WEB RESOURCE: Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/FGF23";
WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/fgf23/";

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): FGF23
CDC HuGE Published Literature: FGF23

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  Microarray Expression Data
 
Expression ratio colors:

GNF Expression Atlas 2 Data from U133A and GNF1H Chips

      
      
      
     
    
     
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Affymetrix All Exon Microarrays

           
Ratios

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -43.90146-0.301 Picture PostScript Text
3' UTR -600.332116-0.284 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR008996 - Cytokine_IL1-like
IPR002348 - IL1_HBGF

Pfam Domains:
PF00167 - Fibroblast growth factor

SCOP Domains:
50353 - Cytokine

Protein Data Bank (PDB) 3-D Structure
MuPIT help

2P39
- X-ray MuPIT


ModBase Predicted Comparative 3D Structure on Q9GZV9
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserNo orthologGenome BrowserNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
MGIRGDEnsembl   
Protein Sequence Protein Sequence   
Alignment Alignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004713 protein tyrosine kinase activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005104 fibroblast growth factor receptor binding
GO:0005105 type 1 fibroblast growth factor receptor binding
GO:0005515 protein binding
GO:0008083 growth factor activity
GO:0016303 1-phosphatidylinositol-3-kinase activity
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity

Biological Process:
GO:0000165 MAPK cascade
GO:0006796 phosphate-containing compound metabolic process
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0010469 regulation of receptor activity
GO:0010966 regulation of phosphate transport
GO:0010980 positive regulation of vitamin D 24-hydroxylase activity
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0030154 cell differentiation
GO:0030500 regulation of bone mineralization
GO:0030502 negative regulation of bone mineralization
GO:0030643 cellular phosphate ion homeostasis
GO:0032026 response to magnesium ion
GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process
GO:0042359 vitamin D metabolic process
GO:0042369 vitamin D catabolic process
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0044320 cellular response to leptin stimulus
GO:0045668 negative regulation of osteoblast differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046854 phosphatidylinositol phosphorylation
GO:0046888 negative regulation of hormone secretion
GO:0051897 positive regulation of protein kinase B signaling
GO:0055062 phosphate ion homeostasis
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071305 cellular response to vitamin D
GO:0071354 cellular response to interleukin-6
GO:0071374 cellular response to parathyroid hormone stimulus
GO:0090080 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
GO:1904383 response to sodium phosphate

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005788 endoplasmic reticulum lumen
GO:0005796 Golgi lumen


-  Descriptions from all associated GenBank mRNAs
  AB047858 - Homo sapiens hypf mRNA for tumor-derived hypophophatemia inducing factor, complete cds.
AF263537 - Homo sapiens FGF23 (FGF23) mRNA, complete cds.
BC096713 - Homo sapiens fibroblast growth factor 23, mRNA (cDNA clone MGC:118769 IMAGE:40000232), complete cds.
BC098147 - Homo sapiens fibroblast growth factor 23, mRNA (cDNA clone MGC:118768 IMAGE:40000231), complete cds.
BC098252 - Homo sapiens fibroblast growth factor 23, mRNA (cDNA clone MGC:118767 IMAGE:40000230), complete cds.
BC069333 - Homo sapiens fibroblast growth factor 23, mRNA (cDNA clone MGC:96984 IMAGE:7262193), complete cds.
AY358323 - Homo sapiens clone DNA142238 FGF23 (UNQ3027) mRNA, complete cds.
AB037973 - Homo sapiens FGF23 mRNA for FGF-23, complete cds.
JD447838 - Sequence 428862 from Patent EP1572962.
JD428733 - Sequence 409757 from Patent EP1572962.
JD427596 - Sequence 408620 from Patent EP1572962.
JD506668 - Sequence 487692 from Patent EP1572962.
JD447855 - Sequence 428879 from Patent EP1572962.
JD363005 - Sequence 344029 from Patent EP1572962.
JD563911 - Sequence 544935 from Patent EP1572962.
JD353917 - Sequence 334941 from Patent EP1572962.
JD553106 - Sequence 534130 from Patent EP1572962.
JD491081 - Sequence 472105 from Patent EP1572962.
JD501473 - Sequence 482497 from Patent EP1572962.
JD504760 - Sequence 485784 from Patent EP1572962.
JD528089 - Sequence 509113 from Patent EP1572962.
JD534030 - Sequence 515054 from Patent EP1572962.
JD328024 - Sequence 309048 from Patent EP1572962.
JD306052 - Sequence 287076 from Patent EP1572962.
JD179255 - Sequence 160279 from Patent EP1572962.
JD315688 - Sequence 296712 from Patent EP1572962.
JD068969 - Sequence 49993 from Patent EP1572962.
JD216488 - Sequence 197512 from Patent EP1572962.
JD067777 - Sequence 48801 from Patent EP1572962.
JD231661 - Sequence 212685 from Patent EP1572962.
JD174744 - Sequence 155768 from Patent EP1572962.
JD290454 - Sequence 271478 from Patent EP1572962.
JD228723 - Sequence 209747 from Patent EP1572962.
JD077643 - Sequence 58667 from Patent EP1572962.
JD100138 - Sequence 81162 from Patent EP1572962.
JD099148 - Sequence 80172 from Patent EP1572962.
JD079289 - Sequence 60313 from Patent EP1572962.
JD122555 - Sequence 103579 from Patent EP1572962.
JD284406 - Sequence 265430 from Patent EP1572962.
JD085656 - Sequence 66680 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04010 - MAPK signaling pathway
hsa04810 - Regulation of actin cytoskeleton
hsa05200 - Pathways in cancer
hsa05218 - Melanoma

Reactome (by CSHL, EBI, and GO)

Protein Q9GZV9 (Reactome details) participates in the following event(s):

R-HSA-8851619 GALNT3 transfers GalNAc to FGF23
R-HSA-190268 FGFR1c binds to Klotho-bound FGF23
R-HSA-190256 FGFR1c binds to FGF
R-HSA-2023451 FGFR1c P252X mutants bind ligand with enhanced affinity
R-HSA-190261 FGFR3c binds to FGF
R-HSA-2012074 FGFR3c P250R mutant binds to ligand with enhanced affinity
R-HSA-190265 FGFR4 binds to FGF
R-HSA-5654511 FGFRL1 dimer binds FGFs
R-HSA-191062 Autocatalytic phosphorylation of Klotho-bound FGFR1c
R-HSA-190429 Autocatalytic phosphorylation of FGFR1c
R-HSA-2023455 Autocatalytic phosphorylation of FGFR1c P252X mutant dimers
R-HSA-190388 Autocatalytic phosphorylation of FGFR3c
R-HSA-2012073 Autocatalytic phosphorylation of FGFR3c P250R mutant
R-HSA-2033472 FGFR2c mutants bind an expanded range of ligands
R-HSA-190326 Autocatalytic phosphorylation of FGFR4
R-HSA-8952289 FAM20C phosphorylates FAM20C substrates
R-HSA-5654167 Activated FGFR1 binds PLCG1
R-HSA-5654569 Activated FGFR1 binds FRS2
R-HSA-5654571 Activated FGFR1 binds FRS3
R-HSA-5654573 Activated FGFR1 binds SHC1
R-HSA-5656064 Activated FGFR1 binds FLRT1,2,3
R-HSA-5654165 p-4Y-PLCG1 dissociates from activated FGFR1
R-HSA-5655269 Activated FGFR1 mutants bind FRS2
R-HSA-5654224 Activated FGFR3 binds PLCG1
R-HSA-5654409 Activated FGFR3 binds FRS2
R-HSA-5654623 Activated FGFR3 binds FRS3
R-HSA-5654625 Activated FGFR3 binds SHC1
R-HSA-5654148 p-4Y-PLCG1 dissociates from activated FGFR3
R-HSA-2077420 FGFR3 mutants bind and are inactivated by tyrosine kinase inhibitors
R-HSA-5655244 Activated FGFR3 mutants bind PLCG1
R-HSA-5655262 Activated FGFR3 mutants bind FRS2
R-HSA-5655247 p-4Y-PLCG1 dissociates from activated FGFR3 mutants
R-HSA-190413 Autocatalytic phosphorylation of FGFR2c
R-HSA-2033486 Autocatalytic phosphorylation of FGFR2c mutants with enhanced ligand binding
R-HSA-5654163 Activated FGFR4 binds PLCG1
R-HSA-5654422 Activated FGFR4 binds FRS2
R-HSA-5654425 Activated FGFR4 binds SHC1
R-HSA-5654651 Activated FGFR4 binds FRS3
R-HSA-5654169 p-4Y-PLCG1 dissociates from activated FGFR4
R-HSA-5654149 Activated FGFR1 phosphorylates PLCG1
R-HSA-5654560 Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2.
R-HSA-5654575 Activated FGFR1 phosphorylates FRS2
R-HSA-5654592 Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1
R-HSA-5654578 Activated FGFR1 phosphorylates FRS3
R-HSA-5654582 Activated FGFR1 phosphorylates SHC1
R-HSA-5654597 Activated FGFR1:p-SHC1 binds GRB2:SOS1
R-HSA-5655240 Activated FGFR1 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1
R-HSA-5655266 Activated FGFR1 mutants:p-FRS2 binds GRB2-SOS1
R-HSA-5655278 Activated FGFR1 mutants phosphorylate FRS2
R-HSA-1839094 Activated FGFR1 mutants and fusions bind PLCG1
R-HSA-1839100 p-4Y- PLCG1 dissociates from activated FGFR1 mutants and fusions
R-HSA-5654222 Activated FGFR3 phosphorylates PLCG1
R-HSA-5654408 Activated FGFR3 phosphorylates FRS2
R-HSA-5654565 Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2.
R-HSA-5654637 Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1
R-HSA-5654628 Activated FGFR3 phosphorylates FRS3
R-HSA-5654634 Activated FGFR3 phosphorylates SHC1
R-HSA-5654646 Activated FGFR3:p-SHC1 binds GRB2:SOS1
R-HSA-5655295 Activated FGFR3 mutants:p-FRS2 binds GRB2-SOS1
R-HSA-5655315 Activated FGFR3 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1
R-HSA-5655270 Activated FGFR3 mutants phosphorylate FRS2
R-HSA-5655243 Activated FGFR3 mutants phosphorylate PLCG1
R-HSA-5654159 Activated FGFR2 binds PLCG1
R-HSA-5654399 Activated FGFR2 binds FRS2
R-HSA-5654404 Activated FGFR2 binds SHC1
R-HSA-5654603 Activated FGFR2 binds FRS3
R-HSA-5654157 p-4Y-PLCG1 dissociates from activated FGFR2
R-HSA-2077424 Point mutants of FGFR2 bind and are inactivated by tyrosine kinase inhibitors
R-HSA-5655339 Activated FGFR2 mutants bind FRS2
R-HSA-5655343 Activated FGFR2 mutants bind PLCG1
R-HSA-5654748 p-4Y-PLCG1 dissociates from activated FGFR2 mutants
R-HSA-5654151 Activated FGFR4 phosphorylates PLCG1
R-HSA-5654418 Activated FGFR4 phosphorylates FRS2
R-HSA-5654566 Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2.
R-HSA-5654659 Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1
R-HSA-5654653 Activated FGFR4 phosphorylates FRS3
R-HSA-5654428 Activated FGFR4 phosphorylates SHC1
R-HSA-5654423 Activated FGFR4:p-SHC1 binds GRB2:SOS1
R-HSA-5654591 Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
R-HSA-5654594 Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
R-HSA-5654673 p-CBL:GRB2 binds p-FRS2:activated FGFR1
R-HSA-5654584 Activated FGFR1:p-FRS bind to PPTN11
R-HSA-5654586 Activated FGFR1:p-FRS binds GRB2:SOS1
R-HSA-5655263 Activated FGFR1 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA
R-HSA-1839098 Activated FGFR1 mutants and fusions phosphorylate PLCG1
R-HSA-5654641 Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
R-HSA-5654730 p-CBL:GRB2 binds p-FRS2:activated FGFR3
R-HSA-5654640 Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
R-HSA-5654416 Activated FGFR3:pFRS binds GRB2:SOS1
R-HSA-5654633 Activated FGFR3:p-FRS bind to PPTN11
R-HSA-5655285 Activated FGFR3 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA
R-HSA-5654147 Activated FGFR2 phosphorylates PLCG1
R-HSA-5654397 Activated FGFR2 phosphorylates FRS2
R-HSA-5654562 Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2
R-HSA-5654612 Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1
R-HSA-5654605 Activated FGFR2 phosphorylates FRS3
R-HSA-5654407 Activated FGFR2 phosphorylates SHC1
R-HSA-5654406 Activated FGFR2:p-SHC1 binds GRB2:SOS1
R-HSA-5655301 Activated FGFR2 mutants phosphorylate PLCG1
R-HSA-5655233 Activated FGFR2 mutants:p-FRS2 binds GRB2-SOS1
R-HSA-5655320 Activated FGFR2 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1
R-HSA-5655268 Activated FGFR2 mutants phosphorylate FRS2
R-HSA-5654662 Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
R-HSA-5654667 Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
R-HSA-5654734 p-CBL:GRB2 binds p-FRS2:activated FGFR4
R-HSA-5654658 Activated FGFR4:p-FRS bind to PPTN11
R-HSA-5654664 Activated FGFR4:p-FRS binds GRB2:SOS1
R-HSA-5654596 Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
R-HSA-5654672 CBL ubiquitinates FRS2 and FGFR1
R-HSA-5654587 Activated FGFR1:p-FRS phosphorylates PPTN11
R-HSA-5654600 Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-5655326 Activated FGFR1 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-5654643 Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
R-HSA-5654679 CBL ubiquitinates FRS2 and FGFR3
R-HSA-5654631 Activated FGFR3 phosphorylates PPTN11
R-HSA-5654647 Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-5655277 Activated FGFR3 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-5654620 Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
R-HSA-5654729 p-CBL:GRB2 binds p-FRS2:activated FGFR2
R-HSA-5654614 Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
R-HSA-5654608 Activated FGFR2:p-FRS bind to PPTN11
R-HSA-5654615 Activated FGFR2:pFRS binds GRB2:SOS1
R-HSA-5655245 Activated FGFR2 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA
R-HSA-5654669 Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
R-HSA-5654684 CBL ubiquitinates FRS2 and FGFR4
R-HSA-5654655 Activated FGFR4 phosphorylates PPTN11
R-HSA-5654426 Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-5654690 FGFR1-associated PI3K phosphorylates PIP2 to PIP3
R-HSA-5654392 Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-5672965 RAS GEFs promote RAS nucleotide exchange
R-HSA-5655290 Activated FGFR1 mutant-associated PI3K phosphorylates PIP2 to PIP3
R-HSA-5654705 FGFR3-associated PI3K phosphorylates PIP2 to PIP3
R-HSA-5654413 Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-5655289 Activated FGFR3 mutant-associated PI3K phosphorylates PIP2 to PIP3
R-HSA-5654622 Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
R-HSA-5654677 CBL ubiquitinates FRS2 and FGFR2
R-HSA-5654607 Activated FGFR2 phosphorylates PPTN11
R-HSA-5654402 Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-5655241 Activated FGFR2 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-5654717 FGFR4-associated PI3K phosphorylates PIP2 to PIP3
R-HSA-5654663 Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-2400009 PI3K inhibitors block PI3K catalytic activity
R-HSA-2316434 PI3K phosphorylates PIP2 to PIP3
R-HSA-5654692 FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
R-HSA-5654709 FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
R-HSA-5654701 FGFR2-associated PI3K phosphorylates PIP2 to PIP3
R-HSA-5654618 Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-5655323 Activated FGFR2 mutant-associated PI3K phosphorylates PIP2 to PIP3
R-HSA-5654714 FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
R-HSA-109699 PI3K-containing complexes phosphorylate PIP2 to PIP3
R-HSA-5654697 FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
R-HSA-190372 FGFR3c ligand binding and activation
R-HSA-190374 FGFR1c and Klotho ligand binding and activation
R-HSA-190239 FGFR3 ligand binding and activation
R-HSA-190373 FGFR1c ligand binding and activation
R-HSA-1839122 Signaling by activated point mutants of FGFR1
R-HSA-1839130 Signaling by activated point mutants of FGFR3
R-HSA-190375 FGFR2c ligand binding and activation
R-HSA-190322 FGFR4 ligand binding and activation
R-HSA-5658623 FGFRL1 modulation of FGFR1 signaling
R-HSA-190242 FGFR1 ligand binding and activation
R-HSA-5654741 Signaling by FGFR3
R-HSA-1839124 FGFR1 mutant receptor activation
R-HSA-2033514 FGFR3 mutant receptor activation
R-HSA-2033519 Activated point mutants of FGFR2
R-HSA-190241 FGFR2 ligand binding and activation
R-HSA-5654743 Signaling by FGFR4
R-HSA-5654736 Signaling by FGFR1
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275 Post-translational protein phosphorylation
R-HSA-5654219 Phospholipase C-mediated cascade: FGFR1
R-HSA-5654693 FRS-mediated FGFR1 signaling
R-HSA-5654688 SHC-mediated cascade:FGFR1
R-HSA-5654687 Downstream signaling of activated FGFR1
R-HSA-190236 Signaling by FGFR
R-HSA-5655302 Signaling by FGFR1 in disease
R-HSA-5654227 Phospholipase C-mediated cascade; FGFR3
R-HSA-5654706 FRS-mediated FGFR3 signaling
R-HSA-5654704 SHC-mediated cascade:FGFR3
R-HSA-8853338 Signaling by FGFR3 point mutants in cancer
R-HSA-1839126 FGFR2 mutant receptor activation
R-HSA-5654738 Signaling by FGFR2
R-HSA-5654228 Phospholipase C-mediated cascade; FGFR4
R-HSA-5654712 FRS-mediated FGFR4 signaling
R-HSA-5654719 SHC-mediated cascade:FGFR4
R-HSA-392499 Metabolism of proteins
R-HSA-597592 Post-translational protein modification
R-HSA-5654726 Negative regulation of FGFR1 signaling
R-HSA-5654689 PI-3K cascade:FGFR1
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-1226099 Signaling by FGFR in disease
R-HSA-5654732 Negative regulation of FGFR3 signaling
R-HSA-5654710 PI-3K cascade:FGFR3
R-HSA-5654708 Downstream signaling of activated FGFR3
R-HSA-5655332 Signaling by FGFR3 in disease
R-HSA-5654221 Phospholipase C-mediated cascade; FGFR2
R-HSA-5654700 FRS-mediated FGFR2 signaling
R-HSA-5654699 SHC-mediated cascade:FGFR2
R-HSA-5655253 Signaling by FGFR2 in disease
R-HSA-5654733 Negative regulation of FGFR4 signaling
R-HSA-5654720 PI-3K cascade:FGFR4
R-HSA-5654716 Downstream signaling of activated FGFR4
R-HSA-162582 Signal Transduction
R-HSA-5663202 Diseases of signal transduction
R-HSA-5654727 Negative regulation of FGFR2 signaling
R-HSA-5654695 PI-3K cascade:FGFR2
R-HSA-5654696 Downstream signaling of activated FGFR2
R-HSA-1643685 Disease
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-5684996 MAPK1/MAPK3 signaling
R-HSA-109704 PI3K Cascade
R-HSA-2219528 PI3K/AKT Signaling in Cancer
R-HSA-9006925 Intracellular signaling by second messengers
R-HSA-199418 Negative regulation of the PI3K/AKT network
R-HSA-5683057 MAPK family signaling cascades
R-HSA-112399 IRS-mediated signalling
R-HSA-74751 Insulin receptor signalling cascade
R-HSA-2428928 IRS-related events triggered by IGF1R
R-HSA-74752 Signaling by Insulin receptor
R-HSA-2428924 IGF1R signaling cascade
R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)

-  Other Names for This Gene
  Alternate Gene Symbols: FGF23_HUMAN, HYPF, NM_020638, NP_065689, Q4V758, Q9GZV9, UNQ3027/PRO9828
UCSC ID: uc001qmq.1
RefSeq Accession: NM_020638
Protein: Q9GZV9 (aka FGF23_HUMAN or FGFN_HUMAN)
CCDS: CCDS8526.1

-  GeneReviews for This Gene
  GeneReviews article(s) related to gene FGF23:
hyper-ftc (Hyperphosphatemic Familial Tumoral Calcinosis)

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_020638.2
exon count: 3CDS single in 3' UTR: no RNA size: 3018
ORF size: 756CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1703.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
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-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.