Human Gene DNPEP (uc002vli.2) Description and Page Index
  Description: Homo sapiens aspartyl aminopeptidase (DNPEP), mRNA.
RefSeq Summary (NM_012100): The protein encoded by this gene is an aminopeptidase which prefers acidic amino acids, and specifically favors aspartic acid over glutamic acid. It is thought to be a cytosolic protein involved in general metabolism of intracellular proteins. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016].
Transcript (Including UTRs)
   Position: hg19 chr2:220,238,180-220,253,598 Size: 15,419 Total Exon Count: 16 Strand: -
Coding Region
   Position: hg19 chr2:220,239,014-220,251,794 Size: 12,781 Coding Exon Count: 14 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr2:220,238,180-220,253,598)mRNA (may differ from genome)Protein (432 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema

-  Comments and Description Text from UniProtKB
DESCRIPTION: SubName: Full=Putative uncharacterized protein DNPEP;
SIMILARITY: Belongs to the peptidase M18 family.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 48.23 RPKM in Testis
Total median expression: 831.38 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -60.60181-0.335 Picture PostScript Text
3' UTR -280.70834-0.337 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001948 - Peptidase_M18
IPR023358 - Peptidase_M18_dom2

Pfam Domains:
PF02127 - Aminopeptidase I zinc metalloprotease (M18)
PF05343 - M42 glutamyl aminopeptidase

SCOP Domains:
53187 - Zn-dependent exopeptidases

ModBase Predicted Comparative 3D Structure on Q53SB6
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 Protein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004177 aminopeptidase activity
GO:0008233 peptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding

Biological Process:
GO:0006508 proteolysis

-  Descriptions from all associated GenBank mRNAs
  AK023005 - Homo sapiens cDNA FLJ12943 fis, clone NT2RP2005162, highly similar to Homo sapiens aspartyl aminopeptidase mRNA.
JD112081 - Sequence 93105 from Patent EP1572962.
JD511595 - Sequence 492619 from Patent EP1572962.
JD286804 - Sequence 267828 from Patent EP1572962.
JD319679 - Sequence 300703 from Patent EP1572962.
JD340751 - Sequence 321775 from Patent EP1572962.
BC000653 - Homo sapiens aspartyl aminopeptidase, mRNA (cDNA clone MGC:899 IMAGE:3343505), complete cds.
AK001777 - Homo sapiens cDNA FLJ10915 fis, clone OVARC1000288, weakly similar to VACUOLAR AMINOPEPTIDASE I PRECURSOR (EC
LF205253 - JP 2014500723-A/12756: Polycomb-Associated Non-Coding RNAs.
BC004854 - Homo sapiens aspartyl aminopeptidase, mRNA (cDNA clone IMAGE:3926570), partial cds.
AF005050 - Homo sapiens aspartyl aminopeptidase mRNA, complete cds.
BC003040 - Homo sapiens aspartyl aminopeptidase, mRNA (cDNA clone IMAGE:2822867), containing frame-shift errors.
AK001977 - Homo sapiens cDNA FLJ11115 fis, clone PLACE1005955, weakly similar to VACUOLAR AMINOPEPTIDASE I PRECURSOR (EC
JD414610 - Sequence 395634 from Patent EP1572962.
AK301919 - Homo sapiens cDNA FLJ56420 complete cds, highly similar to Aspartyl aminopeptidase (EC
JD520145 - Sequence 501169 from Patent EP1572962.
KJ902353 - Synthetic construct Homo sapiens clone ccsbBroadEn_11747 DNPEP gene, encodes complete protein.
DQ891937 - Synthetic construct clone IMAGE:100004567; FLH181576.01X; RZPDo839E11136D aspartyl aminopeptidase (DNPEP) gene, encodes complete protein.
DQ895124 - Synthetic construct Homo sapiens clone IMAGE:100009584; FLH181572.01L; RZPDo839E11135D aspartyl aminopeptidase (DNPEP) gene, encodes complete protein.
AB463418 - Synthetic construct DNA, clone: pF1KB8120, Homo sapiens DNPEP gene for aspartyl aminopeptidase, without stop codon, in Flexi system.
LF318646 - JP 2014500723-A/126149: Polycomb-Associated Non-Coding RNAs.
LF318648 - JP 2014500723-A/126151: Polycomb-Associated Non-Coding RNAs.
CU674320 - Synthetic construct Homo sapiens gateway clone IMAGE:100017672 5' read DNPEP mRNA.
AK021871 - Homo sapiens cDNA FLJ11809 fis, clone HEMBA1006309, highly similar to Homo sapiens aspartyl aminopeptidase mRNA.
AK302809 - Homo sapiens cDNA FLJ58475 complete cds, highly similar to Aspartyl aminopeptidase (EC
KJ902354 - Synthetic construct Homo sapiens clone ccsbBroadEn_11748 DNPEP gene, encodes complete protein.
LF318649 - JP 2014500723-A/126152: Polycomb-Associated Non-Coding RNAs.
MA440830 - JP 2018138019-A/12756: Polycomb-Associated Non-Coding RNAs.
MA554223 - JP 2018138019-A/126149: Polycomb-Associated Non-Coding RNAs.
MA554225 - JP 2018138019-A/126151: Polycomb-Associated Non-Coding RNAs.
MA554226 - JP 2018138019-A/126152: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: BC003040, Q53SB6, Q53SB6_HUMAN
UCSC ID: uc002vli.2
RefSeq Accession: NM_012100
Protein: Q53SB6

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: BC003040.1
exon count: 16CDS single in 3' UTR: no RNA size: 1595
ORF size: 1299CDS single in intron: no Alignment % ID: 99.94
txCdsPredict score: 2632.00frame shift in genome: no % Coverage: 98.87
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.